利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.015 秒)

    SINGLE-VECTOR GENE CONSTRUCT COMPRISING INSULIN AND GLUCOKINASE GENES
    5.
    发明公开
    SINGLE-VECTOR GENE CONSTRUCT COMPRISING INSULIN AND GLUCOKINASE GENES 审中-公开

    公开(公告)号：EP3978614A3

    公开(公告)日：2022-07-27

    申请号：EP21193827.9

    申请日：2016-01-07

    申请人： Universitat Autònoma de Barcelona

    发明人： BOSCH TUBERT, Fàtima ,  GARCIA MARTINEZ, Miquel ,  JIMÉNEZ CENZANO, Veronica ,  HAURIGOT MENDOÇA, Virginia

    IPC分类号： C12N15/864 ,  A61K48/00

    摘要： The invention relates to a viral expression construct and related viral vector and composition and to their use wherein said construct and vector comprise elements a) and b):
    a) a nucleotide sequence encoding an insulin operably linked to a first promoter,
    b) a nucleotide sequence encoding a glucokinase operably linked to a second promoter and said viral expression construct and related viral vector comprise at least one of elements c), d) and e):
    c) the first and the second promoters are positioned in reverse orientation within the expression construct,
    d) the first and the second promoters are positioned in reverse orientation within the expression construct and are located adjacent to each other and
    e) the first promoter is a CMV promoter, preferably a mini CMV promoter.

    SINGLE-VECTOR GENE CONSTRUCT COMPRISING INSULIN AND GLUCOKINASE GENES
    6.
    发明公开
    SINGLE-VECTOR GENE CONSTRUCT COMPRISING INSULIN AND GLUCOKINASE GENES 审中-公开

    公开(公告)号：EP3978614A2

    公开(公告)日：2022-04-06

    申请号：EP21193827.9

    申请日：2016-01-07

    申请人： Universitat Autònoma de Barcelona

    发明人： BOSCH TUBERT, Fàtima ,  GARCIA MARTINEZ, Miquel ,  JIMÉNEZ CENZANO, Veronica ,  HAURIGOT MENDOÇA, Virginia

    IPC分类号： C12N15/864 ,  A61K48/00

    摘要： The invention relates to a viral expression construct and related viral vector and composition and to their use wherein said construct and vector comprise elements a) and b):
    a) a nucleotide sequence encoding an insulin operably linked to a first promoter,
    b) a nucleotide sequence encoding a glucokinase operably linked to a second promoter and said viral expression construct and related viral vector comprise at least one of elements c), d) and e):
    c) the first and the second promoters are positioned in reverse orientation within the expression construct,
    d) the first and the second promoters are positioned in reverse orientation within the expression construct and are located adjacent to each other and
    e) the first promoter is a CMV promoter, preferably a mini CMV promoter.