公开(公告)号：EP3362436A1

公开(公告)日：2018-08-22

申请号：EP16775090.0

申请日：2016-09-14

申请人： Universiteit Antwerpen

发明人： MAES, Bert ,  WYBON, Clarence ,  CHEN, Chen ,  BHEETER, Charles Beromeo ,  SERGUEEV, Serguei

IPC分类号： C07D213/80 ,  C07C67/20 ,  C07D213/81 ,  C07D213/90

CPC分类号： C07D213/90 ,  C07C67/20 ,  C07D213/80 ,  C07D213/81 ,  C07C69/78

摘要： The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).