公开(公告)号：EP3149188A1

公开(公告)日：2017-04-05

申请号：EP15747579.9

申请日：2015-05-27

申请人： Universitetet I Tromsø - Norges Arktiske Universitet

发明人： RÆDER, Inger Lin Uttakleiv ,  ALTERMARK, Bjørn ,  GURUNG, Man Kumari ,  SMALÅS, Arne Oskar

IPC分类号： C12P19/28 ,  C12N9/88

CPC分类号： C12P19/26 ,  C12N9/88 ,  C12Q1/527 ,  C12Y401/03003 ,  C12Y403/03001

摘要： The present invention provides to methods for the production of neuraminic acid or derivatives thereof under alkaline conditions and to the use of neuraminate lyases showing improved characteristics under alkaline conditions in the production of neuraminic acid or its derivatives. More particularly, the present invention employs inter alia a N-acetylneuraminate lyase which has been isolated from the psychrophilic bacterium Aliivibrio salmonicida LFI1238 and has shown to have improved characteristics under alkaline conditions.

摘要翻译： 本发明提供了方法，以用于其在碱性条件下，并使用neuraminate裂合酶示出在生产神经氨酸或其衍生物的碱性条件下具有改善的特性的生产神经氨酸或衍生物。 更具体地，本发明使用，特别是其中已经从嗜冷细菌Aliivibrio鲑LFI1238分离并显现出了N-乙酰神经氨酸裂合酶具有改善的在碱性条件下的特性。