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1.发明公开USE OF A N-ACETYLNEURAMINATE LYASE DERIVED FROM THE BACTERIUM ALIIVIBRIO SALMONICIDA IN THE PRODUCTION OF NEURAMINIC ACID AND DERIVATIVES THEREOF 审中-公开N-乙酰神经氨酸裂合酶从细菌中ALIIVIBRIO鲑USE IN唾液酸及其衍生物的制造
公开(公告)号：EP3149188A1
公开(公告)日：2017-04-05
申请号：EP15747579.9
申请日：2015-05-27
CPC分类号： C12P19/26 , C12N9/88 , C12Q1/527 , C12Y401/03003 , C12Y403/03001
摘要： The present invention provides to methods for the production of neuraminic acid or derivatives thereof under alkaline conditions and to the use of neuraminate lyases showing improved characteristics under alkaline conditions in the production of neuraminic acid or its derivatives. More particularly, the present invention employs inter alia a N-acetylneuraminate lyase which has been isolated from the psychrophilic bacterium Aliivibrio salmonicida LFI1238 and has shown to have improved characteristics under alkaline conditions.
摘要翻译： 本发明提供了方法，以用于其在碱性条件下，并使用neuraminate裂合酶示出在生产神经氨酸或其衍生物的碱性条件下具有改善的特性的生产神经氨酸或衍生物。 更具体地，本发明使用，特别是其中已经从嗜冷细菌Aliivibrio鲑LFI1238分离并显现出了N-乙酰神经氨酸裂合酶具有改善的在碱性条件下的特性。
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公开(公告)号：EP2224009A1
公开(公告)日：2010-09-01
申请号：EP10166705.3
申请日：2007-02-09
发明人： Paccalet, Thomas , Bardor, Muriel , Rihouey, Christophe , Gomord, Véronique , Faye, Loïc , Lerouge, Patrice , Aquin, Stéphanie , Vezina, Louis-Philippe , D'Aoust, Marc-André
IPC分类号： C12N15/82 , C12N15/54 , C12N15/60 , C12N5/04 , C12N5/10 , C12N9/88 , C12N9/90 , A01H1/00 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8245 , C12N9/1085 , C12N9/88 , C12N15/8257 , C12P19/26 , C12P21/005 , C12Y205/01057 , C12Y401/03003
摘要： A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
摘要翻译： 提供了一种在植物中合成唾液酸的方法，以及能够合成唾液酸的植物。 此外，还提供了在植物中产生唾液酸化蛋白质的方法。 合成唾液酸的方法包括提供包含编码N-乙酰神经氨酸（Neu5Ac）合酶或Neu5Ac裂解酶的核苷酸序列的植物，并表达该核苷酸序列从而合成唾液酸。 植物还可以共表达编码差向异构酶，CMP-Neu5Ac合成酶，CMP-Neu5Ac转运蛋白和唾液酸转移酶中的一种或多种的核苷酸序列。
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公开(公告)号：EP1987137A4
公开(公告)日：2009-09-16
申请号：EP07710612
申请日：2007-02-09
申请人： MEDICAGO INC , CENTRE NAT RECH SCIENT , UNIV ROUEN
发明人： PACCALET THOMAS , BARDOR MURIEL , RIHOUEY CHRISTOPHE , GOMORD VERONIQUE , FAYE LOIC , LEROUGE PATRICE , AQUIN STEPHANIE , VEZINA LOUIS-PHILIPPE , D AOUST MARC-ANDRE
IPC分类号： C12N15/82 , A01H1/00 , A01H5/00 , A01H5/10 , C12N5/04 , C12N5/10 , C12N9/88 , C12N9/90 , C12N15/54 , C12N15/60
CPC分类号： C12N15/8245 , C12N9/1085 , C12N9/88 , C12N15/8257 , C12P19/26 , C12P21/005 , C12Y205/01057 , C12Y401/03003
摘要： A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
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公开(公告)号：EP2224009B1
公开(公告)日：2012-10-31
申请号：EP10166705.3
申请日：2007-02-09
发明人： Paccalet, Thomas , Bardor, Muriel , Rihouey, Christophe , Gomord, Véronique , Faye, Loïc , Lerouge, Patrice , Aquin, Stéphanie , Vezina, Louis-Philippe , D'Aoust, Marc-André
IPC分类号： C12N15/82 , C12N15/54 , C12N15/60 , C12N5/04 , C12N5/10 , C12N9/88 , C12N9/90 , A01H5/00 , A01H5/10 , C12P21/00 , C12P19/26
CPC分类号： C12N15/8245 , C12N9/1085 , C12N9/88 , C12N15/8257 , C12P19/26 , C12P21/005 , C12Y205/01057 , C12Y401/03003
摘要： A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
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公开(公告)号：EP1987137B1
公开(公告)日：2011-06-22
申请号：EP07710612.8
申请日：2007-02-09
发明人： PACCALET, Thomas , BARDOR, Muriel , RIHOUEY, Christophe , GOMORD, Véronique , FAYE, Loïc , LEROUGE, Patrice , AQUIN, Stéphanie , VEZINA, Louis-Philippe , D'AOUST, Marc-André
IPC分类号： C12N15/82 , C12N15/54 , C12N15/60 , C12N5/04 , C12N5/10 , C12N9/88 , C12N9/90 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8245 , C12N9/1085 , C12N9/88 , C12N15/8257 , C12P19/26 , C12P21/005 , C12Y205/01057 , C12Y401/03003
摘要： A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
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公开(公告)号：EP1987137A1
公开(公告)日：2008-11-05
申请号：EP07710612.8
申请日：2007-02-09
发明人： PACCALET, Thomas , BARDOR, Muriel , RIHOUEY, Christophe , GOMORD, Véronique , FAYE, Loïc , LEROUGE, Patrice , AQUIN, Stéphanie , VEZINA, Louis-Philippe , D'AOUST, Marc-André
IPC分类号： C12N5/10 , A01H1/00 , A01H5/00 , A01H5/10 , A61K38/14 , C12N15/54 , C12N15/60 , C12N15/82 , C12N5/04 , C12N9/88 , C12N9/90 , C12P19/02 , C12P21/00 , C12N9/10
CPC分类号： C12N15/8245 , C12N9/1085 , C12N9/88 , C12N15/8257 , C12P19/26 , C12P21/005 , C12Y205/01057 , C12Y401/03003
摘要： A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter and a sialyltransferase.
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