-
公开(公告)号：EP3452581A1
公开(公告)日：2019-03-13
申请号：EP17792305.9
申请日：2017-05-03
IPC分类号： C12N5/0789 , C12N5/02 , C12N5/078
-
公开(公告)号：EP3411517A1
公开(公告)日：2018-12-12
申请号：EP17746659.6
申请日：2017-02-06
发明人： WANG, Jean , DICK, John , NG, Stanley , MINDEN, Mark , MITCHELL, Amanda , CHEN, Weihsu, Claire , ZANDSTRA, Peter , KENNEDY, James
CPC分类号： G01N33/57426 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , C40B40/06 , C40B40/08 , G01N2800/52 , G06F19/10 , G06F19/20
摘要： There is described herein a method of prognosing or classifying a subject with acute myeloid leukemia (AML) comprising: (a) determining the expression level of at least 3 genes in a test sample from the subject selected from the group consisting of DNMT3B, ZBTB46, NYNRIN, ARHGAP22, LAPTM4B, MMRN1, DPYSL3, KIAAQ125. CDK6, CPXM1, SOCS2, SMIM24, EMP1, NGFRAP1, CD34, AKR1C3, GPR56; and (b) comparing expression of the at least 3 genes in the test sample with reference expression levels of the at least 3 genes from control samples from a cohort of patients; wherein a difference or similarity in the expression of the at least 3 genes in the test sample and the reference expression levels is used to prognose or classify the subject with AML into a low risk group or a high risk group for worse survival.
-
3.发明公开COMPOSITIONS AND METHODS FOR TREATING HEMATOLOGIC CANCERS TARGETING THE SIRP - CD47 INTERACTION 有权治疗靶向SIRP - CD47相互作用的血液肿瘤的组合物和方法
公开(公告)号：EP2429574A1
公开(公告)日：2012-03-21
申请号：EP10774475.7
申请日：2010-05-14
发明人： WANG, C. Y., Jean , DICK, John , DANSKA, Jayne , JIN, Liqing , THEOCHARIDES, Alexandre , RAJAKUMAR, Sujeetha
CPC分类号： C12Q1/6886 , A61K38/16 , C12Q2600/156
摘要： The invention relates to modulating the SIRPα-CD47 interaction in order to treat hematological cancer and compounds therefor. In some embodiments, there is provided methods and uses of SIRPα polypeptides, fragments and fusion proteins for treating hematological cancer, preferably human acute myeloid leukemia.
摘要翻译： 本发明涉及调节SIRPα-CD47相互作用以治疗血液癌症及其化合物。 在一些实施方案中，提供了用于治疗血液癌症，优选人类急性骨髓性白血病的SIRPα多肽，片段和融合蛋白的方法和用途。
-
4.发明公开
公开(公告)号：EP4311863A3
公开(公告)日：2024-04-10
申请号：EP23214532.6
申请日：2010-05-14
发明人： WANG, C. Y. Jean , DICK, John , DANSKA, Jayne , JIN, Liqing , THEOCHARIDES, Alexandre , RAJAKUMAR, Sujeetha
摘要： A compound for use in a method for treating cancer cells or tumours that are CD47+, the compound comprising a polypeptide capable of modulating the interaction between human Sirpα and human CD47.
-
5.发明公开
公开(公告)号：EP4311863A2
公开(公告)日：2024-01-31
申请号：EP23214532.6
申请日：2010-05-14
发明人： WANG, C. Y. Jean , DICK, John , DANSKA, Jayne , JIN, Liqing , THEOCHARIDES, Alexandre , RAJAKUMAR, Sujeetha
IPC分类号： C12Q1/6886
摘要： A compound for use in a method for treating cancer cells or tumours that are CD47+, the compound comprising a polypeptide capable of modulating the interaction between human Sirpα and human CD47.
-
6.发明授权COMPOSITIONS AND METHODS FOR TREATING HEMATOLOGIC CANCERS TARGETING THE SIRP - CD47 INTERACTION 有权ON SIRP-CD47相互作用LOOKING组合物和方法治疗血癌
公开(公告)号：EP2429574B1
公开(公告)日：2015-05-06
申请号：EP10774475.7
申请日：2010-05-14
发明人： WANG, C. Y., Jean , DICK, John , DANSKA, Jayne , JIN, Liqing , THEOCHARIDES, Alexandre , RAJAKUMAR, Sujeetha
CPC分类号： C12Q1/6886 , A61K38/16 , C12Q2600/156
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.012 秒)
