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公开(公告)号：EP1167377B2
公开(公告)日：2012-08-08
申请号：EP01202811.4
申请日：1995-02-07
申请人： University of Iowa Research Foundation , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
IPC分类号： C12N15/117 , C07H21/00 , A61K31/7088
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
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公开(公告)号：EP1167377B1
公开(公告)日：2009-01-07
申请号：EP01202811.4
申请日：1995-02-07
申请人： University of Iowa Research Foundation , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
IPC分类号： C12N15/11 , C07H21/00 , A61K31/7088
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
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公开(公告)号：EP1167379A3
公开(公告)日：2004-09-08
申请号：EP01202814.8
申请日：1995-02-07
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
摘要： A medicinal composition comprising an oligonucleotide delivery complex formed from an immunostimulatory oligonucleotide containing at least one unmethylated CpG dinucleotide and a sterol, a lipid, or a target cell specific binding agent. The oligonucleotide can be stabilised or a phosphodiester.
摘要翻译： 一种药物组合物，其包含由免疫刺激性寡核苷酸形成的寡核苷酸递送复合物，所述免疫刺激性寡核苷酸含有至少一种未甲基化的CpG二核苷酸和甾醇，脂质或靶细胞特异性结合剂。 寡核苷酸可以被稳定或磷酸二酯。
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公开(公告)号：EP1167377A3
公开(公告)日：2004-09-08
申请号：EP01202811.4
申请日：1995-02-07
申请人： THE UNIVERSITY OF IOWA RESEARCH FOUNDATION , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
摘要： Immunostimulatory phosphodiester oligonucleotides, which contain at least one unmethylated CpG dinucleotide, do not contain a six base palindrome and include more than eight, but no more than 100 nucleotides, for medicinal use.
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公开(公告)号：EP0948510B1
公开(公告)日：2006-07-12
申请号：EP97947311.3
申请日：1997-10-30
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services,
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as synthetic adjuvant.
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