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公开(公告)号：EP1167379A3
公开(公告)日：2004-09-08
申请号：EP01202814.8
申请日：1995-02-07
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
摘要： A medicinal composition comprising an oligonucleotide delivery complex formed from an immunostimulatory oligonucleotide containing at least one unmethylated CpG dinucleotide and a sterol, a lipid, or a target cell specific binding agent. The oligonucleotide can be stabilised or a phosphodiester.
摘要翻译： 一种药物组合物，其包含由免疫刺激性寡核苷酸形成的寡核苷酸递送复合物，所述免疫刺激性寡核苷酸含有至少一种未甲基化的CpG二核苷酸和甾醇，脂质或靶细胞特异性结合剂。 寡核苷酸可以被稳定或磷酸二酯。
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公开(公告)号：EP1167377A3
公开(公告)日：2004-09-08
申请号：EP01202811.4
申请日：1995-02-07
申请人： THE UNIVERSITY OF IOWA RESEARCH FOUNDATION , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
摘要： Immunostimulatory phosphodiester oligonucleotides, which contain at least one unmethylated CpG dinucleotide, do not contain a six base palindrome and include more than eight, but no more than 100 nucleotides, for medicinal use.
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公开(公告)号：EP1167378B1
公开(公告)日：2011-05-11
申请号：EP01202813.0
申请日：1995-02-07
申请人： University of Iowa Research Foundation , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
IPC分类号： C12N15/117 , A61K31/7125 , C07H21/04 , A61K39/39
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
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公开(公告)号：EP1167377B2
公开(公告)日：2012-08-08
申请号：EP01202811.4
申请日：1995-02-07
申请人： University of Iowa Research Foundation , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
IPC分类号： C12N15/117 , C07H21/00 , A61K31/7088
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
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公开(公告)号：EP1167377B1
公开(公告)日：2009-01-07
申请号：EP01202811.4
申请日：1995-02-07
申请人： University of Iowa Research Foundation , United States of America, as represented by the Secretary, Department of Health and Human Services , Coley Pharmaceutical Group, Inc.
IPC分类号： C12N15/11 , C07H21/00 , A61K31/7088
CPC分类号： A61K31/70 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68
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6.发明公开Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant 失效的含有未甲基化CpG二核苷酸的核酸使用含有作为佐剂
公开(公告)号：EP2172216A3
公开(公告)日：2010-11-24
申请号：EP09166906.9
申请日：1998-03-10
申请人： Ottawa Hospital Research Institute , Coley Pharmaceutical GmbH , University of Iowa Research Foundation , The United States of America as represented by the Secretary Department of Health and Human Services
IPC分类号： A61K39/39
CPC分类号： A61K39/292 , A61K39/12 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/55505 , A61K2039/5555 , A61K2039/55561 , A61K2039/57 , C12N2730/10134
摘要： The present invention is based on the finding that nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide affect immune responses in a subject. These nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide can be used to induce an immune response in a subject. The method includes administering to the subject a therapeutically effective amount of nucleic acid encoding an antigenic polypeptide, and a therapeutically effective amount of an oligonucleotide containing at least one unmethylated CpG dinucleotide. The invention also provides a method for treating a subject having or at risk of having viral-mediated disorder, comprising administering to the subject a therapeutically effective amount of a nucleic acid encoding an antigenic polypeptide and an effective amount of an oligonucleotide containing at least one unmethylated CpG dinucleotide
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7.发明公开Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant 失效使用含有未甲基化的CpG二核苷酸的核酸作为佐剂
公开(公告)号：EP2172216A2
公开(公告)日：2010-04-07
申请号：EP09166906.9
申请日：1998-03-10
申请人： Ottawa Hospital Research Institute , Coley Pharmaceutical GmbH , University of Iowa Research Foundation , The United States of America as represented by the Secretary Department of Health and Human Services
IPC分类号： A61K39/39
CPC分类号： A61K39/292 , A61K39/12 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/55505 , A61K2039/5555 , A61K2039/55561 , A61K2039/57 , C12N2730/10134
摘要： The present invention is based on the finding that nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide affect immune responses in a subject. These nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide can be used to induce an immune response in a subject. The method includes administering to the subject a therapeutically effective amount of nucleic acid encoding an antigenic polypeptide, and a therapeutically effective amount of an oligonucleotide containing at least one unmethylated CpG dinucleotide. The invention also provides a method for treating a subject having or at risk of having viral-mediated disorder, comprising administering to the subject a therapeutically effective amount of a nucleic acid encoding an antigenic polypeptide and an effective amount of an oligonucleotide containing at least one unmethylated CpG dinucleotide
摘要翻译： 本发明基于以下发现：含有至少一种未甲基化的胞嘧啶 - 鸟嘌呤（CpG）二核苷酸的核酸影响受试者的免疫应答。 这些含有至少一个未甲基化的胞嘧啶 - 鸟嘌呤（CpG）二核苷酸的核酸可用于在受试者中诱导免疫应答。 该方法包括向受试者施用治疗有效量的编码抗原性多肽的核酸和治疗有效量的含有至少一种未甲基化的CpG二核苷酸的寡核苷酸。 本发明还提供了用于治疗患有或有风险患有病毒介导的疾病的对象的方法，包括向对象施用治疗有效量的编码抗原性多肽的核酸和有效量的含有至少一种未甲基化的寡核苷酸 CpG二核苷酸
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8.发明授权Immunostimulatory nucleic acid molecules comprising GTCGTT motifs 失效免疫刺激素Nukleinsauremolekule死亡GTCGTT动机焓
公开(公告)号：EP2360252B8
公开(公告)日：2017-04-12
申请号：EP10186177.1
申请日：1997-10-30
申请人： University Of Iowa Research Foundation , THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Krieg, Arthur , Klinman, Dennis , Weiner, George
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as synthetic adjuvant.
摘要翻译： 公开了含有调节免疫应答的非甲基化CpG二核苷酸的核酸序列，包括刺激免疫激活，细胞因子产生，NK溶解活性和B细胞增殖的Th1模式。 序列也可用作合成佐剂。
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公开(公告)号：EP1714969A2
公开(公告)日：2006-10-25
申请号：EP06115792.1
申请日：1997-10-30
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services,
IPC分类号： C07H21/00
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as synthetic adjuvant.
摘要翻译： 公开了含有调节免疫应答的非甲基化CpG二核苷酸的核酸序列，包括刺激免疫激活，细胞因子产生，NK溶解活性和B细胞增殖的Th1模式。 序列也可用作合成佐剂。
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10.发明公开Immunostimulatory nucleic acid molecules comprising GTCGTT motifs 失效免疫刺激素Nukleinsauremolekule死亡GTCGTT动机焓
公开(公告)号：EP2360252A1
公开(公告)日：2011-08-24
申请号：EP10186177.1
申请日：1997-10-30
申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Krieg, Arthur , Klinman, Dennis , Weiner, George
CPC分类号： A61K39/00 , A61K31/00 , A61K31/4706 , A61K31/7048 , A61K31/711 , A61K31/7125 , A61K39/39 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12Q1/68 , Y02A50/412 , Y02A50/464 , Y02A50/466 , Y02A50/54
摘要： An isolated immunostimulatory oligonucleotide comprising two or more unmethylated CpG dinucleotides, and having a sequence including the following formula:
5'N 1 X 1 X 2 CGTTN 2 3'
wherein the immunostimulatory oligonucleotide includes a modified backbone, at least one nucleotide separates consecutive CpGs, X 1 X 2 is GpT or ApT, N 1 is any nucleotide that includes a 5' TC or TG, N 1 + N 2 is from 0-26 bases, and the immunostimulatory oligonucleotide is from 8-30 bases in length and begins with TC or TG at the 5' end, with the proviso that neither N 1 nor N 2 contains a CCGG quadmer or more than one CCG or CGG trimer.摘要翻译： 包含两个或更多个未甲基化的CpG二核苷酸的分离的免疫刺激性寡核苷酸，并且具有包括下式的序列：ƒ€ƒ€ƒ€ƒ€ƒ€ƒ5'N1 X 1 X 2 CGTTN 2 3'其中 免疫刺激性寡核苷酸包括修饰的主链，至少一个核苷酸分离连续的CpG，X 1 X 2是GpT或ApT，N 1是包括5'TC或TG的任何核苷酸，N 1 + N 2是0-26个碱基， 免疫刺激寡核苷酸长度为8-30个碱基，以5'末端的TC或TG开始，条件是N 1和N 2均不含有CCGG四聚体或多于一个CCG或CGG三聚体。
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