公开(公告)号：EP2015073A1

公开(公告)日：2009-01-14

申请号：EP07112228.7

申请日：2007-07-11

申请人： University of Lausanne

发明人： Thome, Margot ,  Rebeaud, Fabien ,  Hailfinger, Stephan

IPC分类号： G01N33/573 ,  C12Q1/37

CPC分类号： C12Q1/37

摘要： The present invention is based on the surprising finding of a proteolytic cleavage function of human Maltl. More particularly, the present invention relates to enzyme and screening assays, methods for assessing cleaving activity, methods for screening, isolated polypeptides, antibodies and inhibitors of Maltl. The present invention also relates to the use of Maltl as a proteolytic enzyme and the use of compounds comprising a peptide comprising an amino acid sequence according to any one of SEQ ID NO: 1-44 as substrates susceptible for specific proteolytic cleavage.

摘要翻译： 本发明基于人类Maltl蛋白水解切割功能的惊人发现。 更具体地，本发明涉及酶和筛选测定法，评估切割活性的方法，筛选方法，分离的多肽，抗体和Malt1抑制剂。 本发明还涉及Maltl作为蛋白水解酶的用途，以及包含含有根据SEQ ID NO：1-44中任一项所述的氨基酸序列的肽的化合物作为易于特异性蛋白水解切割的底物的用途。