公开(公告)号：EP2826860B1

公开(公告)日：2018-08-22

申请号：EP14181861.7

申请日：2011-04-22

申请人： University of Massachusetts

发明人： Gao, Guangping ,  Zhang, Hongwei ,  Wang, Hongyan ,  Xu, Zuoshang

IPC分类号： C12N15/00 ,  C12N15/86 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K31/713 ,  A61K38/50 ,  A61K48/00 ,  A61K48/0058 ,  A61K48/0075 ,  C12N7/00 ,  C12N9/80 ,  C12N15/1137 ,  C12N15/635 ,  C12N15/8645 ,  C12N2310/141 ,  C12N2750/14133 ,  C12N2750/14141 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12N2750/14162 ,  C12N2810/10 ,  C12N2840/007 ,  C12Y305/01015

摘要： The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.

公开(公告)号：EP3514232A1

公开(公告)日：2019-07-24

申请号：EP18248259.6

申请日：2011-04-22

申请人： University of Massachusetts

发明人： Gao, Guangping ,  Zhang, Hongwei ,  Wang, Hongyan ,  Xu, Zuoshang

IPC分类号： C12N15/00 ,  C12N15/86 ,  A61K48/00

摘要： The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.

公开(公告)号：EP3567106A1

公开(公告)日：2019-11-13

申请号：EP18248250.5

申请日：2011-04-22

申请人： University of Massachusetts

发明人： Gao, Guangping ,  Zhang, Hongwei ,  Wang, Hongyan ,  Xu, Zuoshang

IPC分类号： C12N15/00 ,  C12N15/86 ,  A61K48/00

摘要： The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.

公开(公告)号：EP2826860A1

公开(公告)日：2015-01-21

申请号：EP14181861.7

申请日：2011-04-22

申请人： The University of Massachusetts

发明人： Gao, Guangping ,  Zhang, Hongwei ,  Wang, Hongyan ,  Xu, Zuoshang

IPC分类号： C12N15/00 ,  C12N15/86 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K31/713 ,  A61K38/50 ,  A61K48/00 ,  A61K48/0058 ,  A61K48/0075 ,  C12N7/00 ,  C12N9/80 ,  C12N15/1137 ,  C12N15/635 ,  C12N15/8645 ,  C12N2310/141 ,  C12N2750/14133 ,  C12N2750/14141 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12N2750/14162 ,  C12N2810/10 ,  C12N2840/007 ,  C12Y305/01015

摘要： The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.

摘要翻译： 本发明在一些方面涉及可用于靶向转基因到CNS组织的重组腺相关病毒，以及包含其的组合物及其使用方法。 在一些方面，本发明提供了用于治疗CNS相关疾病的方法和组合物。