利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

98 条记录 (耗时 0.029 秒)

    CHIMERIC CAPSIDS
    5.
    发明公开
    CHIMERIC CAPSIDS 审中-公开
    CHIMÄREKAPSIDE

    公开(公告)号：EP3151866A1

    公开(公告)日：2017-04-12

    申请号：EP15807546.5

    申请日：2015-06-09

    申请人： Voyager Therapeutics, Inc.

    发明人： KOTIN, Robert ,  HOU, Jinzhao ,  MCLAUGHLIN, James

    IPC分类号： A61K48/00 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145

    摘要： The present invention relates to viral vectors and methods of their production and use. Specifically, the disclosure provides compositions and methods for adeno-associated viral (AAV) vector production, wherein AAV vector comprising chimeric polynucleotides encoding chimeric capsid for improved compositions production. Further disclosed are variable regions (VR) in different AAV serotypes for producing a chimeric capsid, and methods for delivering transgenes using the vectors produced.

    摘要翻译： 本发明涉及病毒载体及其生产和使用方法。

    ADENO-ASSOCIATED VIRUS WITH SITE-DIRECTED MUTAGENESIS AND SITE-DIRECTED MODIFICATION, AND PREPARATION METHOD AND APPLICATION THEREFOR
    8.
    发明公开
    ADENO-ASSOCIATED VIRUS WITH SITE-DIRECTED MUTAGENESIS AND SITE-DIRECTED MODIFICATION, AND PREPARATION METHOD AND APPLICATION THEREFOR 审中-公开
    腺相关与有关当局展望诱变和地方前瞻性和修改过程及其应用病毒

    公开(公告)号：EP3070095A1

    公开(公告)日：2016-09-21

    申请号：EP14857377.7

    申请日：2014-10-30

    申请人： Peking University

    发明人： ZHOU, Demin ,  ZHANG, Chuanling ,  XIAO, Sulong ,  YAO, Tianzhuo ,  ZHENG, Yongxiang ,  YU, Fei ,  SI, Longlong ,  ZHANG, Lihe

    IPC分类号： C07K14/015 ,  C12N15/864 ,  C12N15/35 ,  C12N15/70 ,  C12N15/85 ,  C12N1/21 ,  A61K48/00

    CPC分类号： C07K14/005 ,  A61K39/23 ,  A61K2039/53 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14134 ,  C12N2750/14143 ,  C12N2750/14145 ,  C12N2750/14151

    摘要： The present invention relates to an adeno-associated virus with site-directed mutagenesis and site-specific modification, and a preparation method and uses thereof. Specifically, the present invention uses genetic code expansion techniques to incorporate non-natural amino acid into an adeno-associated virus capsid protein VP1 or fragment thereof, thereby obtaining an adeno-associated virus with site-directed mutagenesis using the non-natural amino acid. The adeno-associated virus with site-directed mutagenesis is equivalent to a wild-type virus in terms of production, transduction and mobility, can couple with other functional molecules, such as targeting molecules, and can carry a functional gene in a normal manner, which indicates that the adeno-associated virus with site-directed mutagenesis can be used as a tool adeno-associated virus, and applied in various aspects associated with adeno-associated virus such as finding adeno-associated virus binding proteins or using as target genetic therapy vector.

    摘要翻译： 本发明涉及到对腺相关病毒与位点定向诱变和位点特异性修饰，及制备方法及其用途。 具体而言，本发明使用遗传密码的扩展技术，以非天然氨基酸并入于腺相关病毒衣壳蛋白VP1或其片段，由此使用非天然氨基酸获得腺相关病毒的同位点定向诱变。 用定点诱变的腺相关病毒是等效于野生型病毒在生产，转导和移动性方面，可以夫妇与其他功能性分子，：如靶向分子，可携带功能基因以正常方式， 这表明没有与定点突变的腺相关病毒可作为一种工具，腺相关病毒，并应用与腺相关病毒相关的各个方面：如发现腺相关病毒结合蛋白或使用作为目标基因治疗 向量。