公开(公告)号：EP2460878B1

公开(公告)日：2015-03-25

申请号：EP10803804.3

申请日：2010-07-27

申请人： University of Medicine & Dentistry of New Jersey ,  Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： ZHU, Hua ,  LI, Yimin ,  XIA, Ningshao ,  CHENG, Tong ,  YE, Xiangzhong

IPC分类号： C12N7/00 ,  C12N7/04 ,  C12N7/01 ,  A61K39/25 ,  A61P31/22 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/25 ,  A61K2039/5254 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16734

摘要： Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

公开(公告)号：EP2460878A9

公开(公告)日：2012-08-22

申请号：EP10803804.3

申请日：2010-07-27

申请人： New Jersey Medical School ,  Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： ZHU, Hua ,  LI, Yimin ,  XIA, Ningshao ,  CHENG, Tong ,  YE, Xiangzhong

IPC分类号： C12N7/00 ,  C12N7/04 ,  C12N7/01 ,  A61K39/25 ,  A61P31/22 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/25 ,  A61K2039/5254 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16734

摘要： Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

摘要翻译： 提供了ORF7缺陷型水痘病毒，包含该病毒的疫苗及其用途，以及该病毒的生产方法。

公开(公告)号：EP2460878A1

公开(公告)日：2012-06-06

申请号：EP10803804.3

申请日：2010-07-27

申请人： New Jersey Medical School ,  Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： ZHU, Hua ,  LI, Yimin ,  XIA, Ningshao ,  CHENG, Tong ,  YE, Xiangzhong

IPC分类号： C12N7/00 ,  C12N7/04 ,  C12N7/01 ,  A61K39/25 ,  A61P31/22 ,  C12N15/63 ,  C12N5/10

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/25 ,  A61K2039/5254 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/16722 ,  C12N2710/16734

摘要： Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

摘要翻译： 提供了一种ORF7缺陷型水痘病毒，包含病毒的疫苗及其用途，以及用于生产病毒的方法。

公开(公告)号：EP4378951A1

公开(公告)日：2024-06-05

申请号：EP22848410.1

申请日：2022-07-21

申请人： Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  Xiamen University

发明人： CHENG, Tong ,  ZHU, Rui ,  YANG, Hongwei ,  XU, Longfa ,  LIN, Yu ,  ZHOU, Zhenhong ,  YE, Xiangzhong ,  XIA, Ningshao

IPC分类号： C07K7/08 ,  C12N15/00 ,  A61K39/125 ,  A61K48/00

CPC分类号： C12N15/00 ,  C07K7/08 ,  A61K48/00 ,  A61K39/125

摘要： The present invention belongs to the field of immunobiology, and relates to an epitope polypeptide, such as a general affinity epitope polypeptide of human rhinovirus, and the use thereof. The present invention further relates to an antibody capable of binding to the epitope polypeptide and the use thereof. The present invention further relates to the use of the affinity epitope polypeptide or the antibody in the preparation of drugs or in methods for treating and/or preventing and/or diagnosing human rhinovirus and/or identifying a titer of human rhinovirus and/or identifying a titer of a neutralizing antibody of human rhinovirus. The affinity epitope polypeptide and antibody can be used in drugs or methods for treating and/or preventing and/or diagnosing human rhinovirus and/or identifying a titer of human rhinovirus and/or identifying a titer of a neutralizing antibody of human rhinovirus.

公开(公告)号：EP3783100A1

公开(公告)日：2021-02-24

申请号：EP19788373.9

申请日：2019-04-15

申请人： Xiamen University ,  Yang Sheng Tang Company, Ltd.

发明人： CHENG, Tong ,  WANG, Wei ,  YE, Xiangzhong ,  FU, Wenkun ,  PAN, Dequan ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C12N7/01 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04

摘要： Provided are Coxsackie virus CVB1 or a modified form thereof, or a genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or a nucleic acid molecule of a complement sequence of the genomic sequence or cDNA sequence, the use of same for treating tumors in subjects including humans, and the use of same in the preparation of a pharmaceutical composition for treating tumors in subjects including humans. Also provided is a method for treating tumors, comprising administering CVB1 or the modified form thereof, or the genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or the nucleic acid molecule of the complement sequence of the genomic sequence or cDNA sequence to a subject in need thereof.

公开(公告)号：EP3656854A1

公开(公告)日：2020-05-27

申请号：EP18835927.7

申请日：2018-07-18

申请人： Xiamen University ,  Yang Sheng Tang Company, Ltd.

发明人： CHENG, Tong ,  WANG, Wei ,  WAN, Junkai ,  FU, Wenkun ,  YE, Xiangzhong ,  ZHANG, Jun ,  XIA, Ningshao

IPC分类号： C12N7/00 ,  C12N15/11 ,  A61K35/76 ,  A61P35/00

摘要： Provided are an enterovirus D68 (EV-D68) or a modified form thereof, or a nucleic acid molecule comprising a genomic sequence or cDNA sequence of the EV-D68 or a modified form thereof, or a complementary sequence of the genomic sequence or cDNA sequence, or a pharmaceutical composition comprising the EV-D68 or a modified form thereof, or the nucleic acid molecule, and use of the EV-D68 or a modified form thereof, or the nucleic acid molecule in the manufacture of a pharmaceutical composition for treating a tumor.