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1.发明公开GENETICALLY MODIFIED PROBIOTIC FOR THE TREATMENT OF PHENYLKETONURIA (PKU) DISEASE 有权基因改造益生菌疾病苯丙酮尿症的治疗（PKU）
公开(公告)号：EP2877190A1
公开(公告)日：2015-06-03
申请号：EP13745543.2
申请日：2013-07-26
CPC分类号： A61K35/747 , A61K35/741 , A61K38/51 , A61K2035/115 , C12Y403/01024
摘要： A GMP adapted to provide the PAL gene for the treatment of PKU when administered orally. The GMP of the present invention may include a probiotic, a PAL gene to be expressed using the probiotic, wherein the PAL gene is functionally attached to a promoter and a ribosome binding site, and may be codon-optimized for expression in a certain host organism. A method of treating the metabolic disease of PKU by oral administration and ingestion of a GMP is also provided.
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2.发明授权GENETICALLY MODIFIED PROBIOTIC FOR THE TREATMENT OF PHENYLKETONURIA (PKU) DISEASE 有权基因改造益生菌疾病苯丙酮尿症的治疗（PKU）
公开(公告)号：EP2877190B1
公开(公告)日：2016-11-02
申请号：EP13745543.2
申请日：2013-07-26
IPC分类号： A61K35/747 , A61K38/44 , A61K48/00 , A61P3/00
CPC分类号： A61K35/747 , A61K35/741 , A61K38/51 , A61K2035/115 , C12Y403/01024
摘要： A GMP adapted to provide the PAL gene for the treatment of PKU when administered orally. The GMP of the present invention may include a probiotic, a PAL gene to be expressed using the probiotic, wherein the PAL gene is functionally attached to a promoter and a ribosome binding site, and may be codon-optimized for expression in a certain host organism. A method of treating the metabolic disease of PKU by oral administration and ingestion of a GMP is also provided.
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