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公开(公告)号：EP4286527A3
公开(公告)日：2023-12-27
申请号：EP23201329.2
申请日：2019-09-16
摘要： A method of antimicrobial susceptibility testing comprises: preparing samples of microorganisms suspended in an electrolyte, comprising a first sample of the microorganisms unexposed to antimicrobial agents and a second sample of the microorganisms exposed to an antimicrobial agent; passing the first sample through an impedance flow cytometer to obtain a first impedance signal representing one or more components of impedance values of the unexposed microorganisms; passing the second sample through the impedance flow cytometer to obtain a second impedance signal representing one or more components of the impedance values of the exposed microorganisms; comparing the first impedance signal and the second impedance signal; and determining a susceptibility of the microorganisms to the antimicrobial agent based on any differences between the first impedance signal and second impedance signal. A method of impedance flow cytometry comprises: flowing a sample of fluid comprising particles suspended in an electrolyte along a flow channel; applying electrical signals to current paths through the fluid, the current paths comprising at least a first current path, a second current path, a further first current path and a further second current path, wherein the electrical signals applied to the first current path and the further first current path have a frequency, magnitude and phase and the electrical signals applied to the second current path and the further second current path have substantially equal frequency and magnitude and opposite phase to the electrical signals applied to the first current path and the second current path; detecting current flow in the current paths; producing a first summed signal representing the sum of the current flow detected in the first current path and the second current path, and a second summed signal representing the sum of the current flow detected in the further first current path and the further second current path; and obtaining a differential signal representing the difference between the first summed signal and the second summed signal.
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公开(公告)号：EP3853585A1
公开(公告)日：2021-07-28
申请号：EP19772813.2
申请日：2019-09-16
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公开(公告)号：EP4286527A2
公开(公告)日：2023-12-06
申请号：EP23201329.2
申请日：2019-09-16
IPC分类号： C12Q1/18
摘要： A method of antimicrobial susceptibility testing comprises: preparing samples of microorganisms suspended in an electrolyte, comprising a first sample of the microorganisms unexposed to antimicrobial agents and a second sample of the microorganisms exposed to an antimicrobial agent; passing the first sample through an impedance flow cytometer to obtain a first impedance signal representing one or more components of impedance values of the unexposed microorganisms; passing the second sample through the impedance flow cytometer to obtain a second impedance signal representing one or more components of the impedance values of the exposed microorganisms; comparing the first impedance signal and the second impedance signal; and determining a susceptibility of the microorganisms to the antimicrobial agent based on any differences between the first impedance signal and second impedance signal. A method of impedance flow cytometry comprises: flowing a sample of fluid comprising particles suspended in an electrolyte along a flow channel; applying electrical signals to current paths through the fluid, the current paths comprising at least a first current path, a second current path, a further first current path and a further second current path, wherein the electrical signals applied to the first current path and the further first current path have a frequency, magnitude and phase and the electrical signals applied to the second current path and the further second current path have substantially equal frequency and magnitude and opposite phase to the electrical signals applied to the first current path and the second current path; detecting current flow in the current paths; producing a first summed signal representing the sum of the current flow detected in the first current path and the second current path, and a second summed signal representing the sum of the current flow detected in the further first current path and the further second current path; and obtaining a differential signal representing the difference between the first summed signal and the second summed signal.
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公开(公告)号：EP4400034A1
公开(公告)日：2024-07-17
申请号：EP24154027.7
申请日：2017-03-07
发明人： MORGAN, Hywel , CHEONG, Ying , MACKLON, Nick , LU, Shilong
CPC分类号： A61B5/6875 , A61B5/0002 , A61B5/035 , A61B5/4325 , A61B2560/021920130101
摘要： An intra-uterine monitoring system is described. The system comprises an implantable sensor device, shaped and dimensioned for implantation in a uterus for measuring conditions within the uterus to generate sensor data, and a wearable receiver device, for wirelessly receiving the sensor data generated by the implantable sensor device. In this way, real-time, in-vivo monitoring of the intra-uterine environment can be performed. The implantable sensor device can be kept small and simple, requiring only the mechanical and electronic structures necessary to take sensor measurements and transmit those to the receiver device. By making the receiver device wearable, it can be kept in relatively close proximity to the implantable sensor device on a long-term basis, making regular monitoring viable.
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公开(公告)号：EP4008242A1
公开(公告)日：2022-06-08
申请号：EP22151697.4
申请日：2018-08-01
发明人： MORGAN, Hywel , LU, Shilong , CHEONG, Ying
摘要： A wearable antenna is described, for wirelessly receiving sensor data generated by an implantable sensor device implanted in a uterus, the wearable antenna, in use, extending around the waist of the wearer's body, and having a downwardly extending portion for location at the front of the wearer's body. In this way, an improved electromagnetic interaction between the wearable antenna and the implantable sensor can be achieved. Further, the wearable antenna may have an undulating shape around at least a portion of the wearer's waist, to permit expansion and contraction of the wearable antenna about the wearer's waist.
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公开(公告)号：EP4345442A3
公开(公告)日：2024-07-10
申请号：EP24156377.4
申请日：2019-09-16
发明人： MORGAN, Hywel , SPENCER, Daniel
IPC分类号： B01L3/00 , G01N15/10 , G01N15/1031
CPC分类号： G01N15/1031 , G01N2015/100620130101 , B01L3/502715 , B01L3/502761 , B01L2300/064520130101 , G01N15/1023
摘要： Impedance flow cytometry apparatus comprises: a flow channel for carrying a flow of fluid comprising particles suspended in an electrolyte from an inlet to an outlet; a first electrode group and a second electrode group, each electrode group providing first and second current paths through fluid flowing in the flow channel; wherein each electrode group comprises: a first signal electrode to provide to the first current path a first electrical signal of frequency, magnitude and phase; a second signal electrode to provide to the second current path a second electrical signal of substantially equal frequency and magnitude as the first electrical signal and of opposite phase to the first electrical signal; and one or more measurement electrodes to detect current flow in the first current path and the second current path and produce a summed signal representing the sum of the current flow in the first current path and the current flow in the second current path; wherein the first electrode group produces a first summed signal and the second electrode group produces a second summed signal; and circuitry to determine a differential signal representing the difference between the first summed signal and the second summed signal.
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公开(公告)号：EP3682230A1
公开(公告)日：2020-07-22
申请号：EP18797019.9
申请日：2018-09-13
发明人： MORGAN, Hywel , MINGELS, Roel
IPC分类号： G01N27/416 , A61B5/00 , G01N27/414
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8.发明公开
公开(公告)号：EP2986965A1
公开(公告)日：2016-02-24
申请号：EP14719201.7
申请日：2014-04-15
IPC分类号： G01N15/10
CPC分类号： G01N15/1031 , G01N2015/0053 , G01N2015/1006 , G01N2015/1087
摘要： A method of electrically measuring the electrical properties of individual particles flowing in a liquid, which method comprises: (i) providing apparatus (3) which is for electrically measuring the individual particles and which has: (a) a fluidic channel (5) for receiving a liquid (6) having the individual particles (4) in suspension in the liquid (6); (b) a first electrode arrangement (8) having at least one measurement electrode (16) and at least one signal electrode (11); and (c) at least one other electrode arrangement (9) having at least one measurement electrode (18) and at least one signal electrode (13); (ii) providing a flow of the liquid (6) through the fluidic channel (5); (iii) applying a first electrical signal through the liquid (6) and along a first conduction path between the measurement electrode (16) and the signal electrode (11) of the first electrode arrangement (8); (iv) applying an electrical signal through the liquid (6) and along at least one other conduction path; (v) comparing the electrical signal between the first and the other conduction paths to generate a comparison signal; (vi) detecting an individual particle passing through the apparatus (3) by detecting a feature of the comparison signal of the individual particle, and obtaining at least one output waveform; (vii) measuring a height-related feature of the output waveform of the individual particle, and generating a first order assessment of the electrical properties of the individual particle; and (viii) assessing the shape of the output waveform to perform a second order adjustment to the first order assessment of the electrical properties of the individual particle, with the second order adjustment utilising data on a perceived degree of error in the first order assessment based on information on a known relationship between the waveform shape and the error in the first order assessment.
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公开(公告)号：EP4345442A2
公开(公告)日：2024-04-03
申请号：EP24156377.4
申请日：2019-09-16
发明人： MORGAN, Hywel , SPENCER, Daniel
IPC分类号： G01N15/10
摘要： Impedance flow cytometry apparatus comprises: a flow channel for carrying a flow of fluid comprising particles suspended in an electrolyte from an inlet to an outlet; a first electrode group and a second electrode group, each electrode group providing first and second current paths through fluid flowing in the flow channel; wherein each electrode group comprises: a first signal electrode to provide to the first current path a first electrical signal of frequency, magnitude and phase; a second signal electrode to provide to the second current path a second electrical signal of substantially equal frequency and magnitude as the first electrical signal and of opposite phase to the first electrical signal; and one or more measurement electrodes to detect current flow in the first current path and the second current path and produce a summed signal representing the sum of the current flow in the first current path and the current flow in the second current path; wherein the first electrode group produces a first summed signal and the second electrode group produces a second summed signal; and circuitry to determine a differential signal representing the difference between the first summed signal and the second summed signal.
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公开(公告)号：EP4256316A1
公开(公告)日：2023-10-11
申请号：EP21820304.0
申请日：2021-11-25
IPC分类号： G01N27/333 , G01N27/327 , A61B5/1468 , A61B5/00
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