公开(公告)号：EP4245370A2

公开(公告)日：2023-09-20

申请号：EP23188169.9

申请日：2011-07-12

申请人： University of Southern California ,  California Institute of Technology ,  The Regents of University of California

发明人： CLEGG, Dennis ,  JOHNSON, Lincoln Vallance ,  GRUBBS, Robert ,  AHUJA, Ashish ,  HUMAYUN, Mark ,  TAI, Yu-Chong ,  HIKITA, Sherry T ,  HINTON, David

IPC分类号： A61P27/00

摘要： A substrate for cellular therapy to treat diseased or damaged ocular tissue wherein the substrate comprises:
a) a basal surface that comprises a single continuous support that comprises a plurality of pores or cylindrical recesses and wherein the plurality of pores of cylindrical recesses are in a periodic pattern in the single continuous support
and
b) a substantially homogeneous apical surface produced by deposition of parylene over the basal single continuous support,

wherein the apical surface provides a surface for cellular growth, and
wherein the apical surface is configured to facilitate the growth of a monolayer of cells and the basal single continuous support is configured to inhibit cell growth.

公开(公告)号：EP4245370A3

公开(公告)日：2023-11-29

申请号：EP23188169.9

申请日：2011-07-12

申请人： University of Southern California ,  California Institute of Technology ,  The Regents of University of California

发明人： CLEGG, Dennis ,  JOHNSON, Lincoln Vallance ,  GRUBBS, Robert ,  AHUJA, Ashish ,  HUMAYUN, Mark ,  TAI, Yu-Chong ,  HIKITA, Sherry T ,  HINTON, David

IPC分类号： A61L27/38 ,  A61F2/14 ,  A61K35/30 ,  A61P27/00 ,  C12N5/079

摘要： A substrate for cellular therapy to treat diseased or damaged ocular tissue wherein the substrate comprises:
a) a basal surface that comprises a single continuous support that comprises a plurality of pores or cylindrical recesses and wherein the plurality of pores of cylindrical recesses are in a periodic pattern in the single continuous support
and
b) a substantially homogeneous apical surface produced by deposition of parylene over the basal single continuous support,

wherein the apical surface provides a surface for cellular growth, and
wherein the apical surface is configured to facilitate the growth of a monolayer of cells and the basal single continuous support is configured to inhibit cell growth.

公开(公告)号：EP2593117B1

公开(公告)日：2019-03-20

申请号：EP11807411.1

申请日：2011-07-12

申请人： University of Southern California ,  California Institute of Technology ,  The Regents of University of California

发明人： HUMAYUN, Mark ,  AHUJA, Ashish ,  TAI, Yu-Chong ,  HINTON, David ,  GRUBBS, Robert ,  CLEGG, Dennis ,  JOHNSON, Lincoln Vallance ,  HIKITA, Sherry T.

IPC分类号： A61F2/14 ,  A61K35/44 ,  A61L27/38 ,  B32B3/00 ,  A61K35/30 ,  A61L27/18 ,  A61K9/00 ,  A61K47/34