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    METHOD FOR MANUFACTURING SUBSTANCE CONTAINING NOBILETIN AND TANGERETIN DERIVED FROM CITRUS FRUITS, AND NOBILETIN- AND TANGERETIN-CONTAINING SUBSTANCE OBTAINED THEREBY
    1.
    发明公开
    METHOD FOR MANUFACTURING SUBSTANCE CONTAINING NOBILETIN AND TANGERETIN DERIVED FROM CITRUS FRUITS, AND NOBILETIN- AND TANGERETIN-CONTAINING SUBSTANCE OBTAINED THEREBY 有权
    方法用于生产具有川陈皮素和柑橘类水果的橘皮物质，从而产生并NOBILETIN- TANGERETINHALTIGE物质

    公开(公告)号：EP2907395A1

    公开(公告)日：2015-08-19

    申请号：EP13845755.1

    申请日：2013-08-09

    申请人： University of The Ryukyus ,  Okinawa Research Center Co. Ltd.

    发明人： TERUYA, Toshiaki ,  TERUYA, Yuto ,  SUGIYAMA, Saki ,  WOO, Je-Tae

    IPC分类号： A23L1/212 ,  C07D311/30 ,  A23L1/30 ,  A61K36/00 ,  A61K36/75 ,  A61P3/10 ,  A61P25/28 ,  A61P35/00

    CPC分类号： A61K36/752 ,  A23L19/00 ,  A23L33/105 ,  A61K31/352 ,  A61K2236/00 ,  C07D311/30

    摘要： The object of the invention is to provide a method of manufacturing a fraction containing nobiletin and tangeretin at high concentrations, which is excellent in terms of safety, economic efficiency, and the potential for industrialization.
    The object is achieved by a method of manufacturing a composition containing nobiletin and tangeretin, comprising (1-1) a step of treating citrus fruit with hot water to obtain a hot water-treated product; (1-2) a step of drying the hot water-treated product to obtain a dried product; (1-3) a step of treating the dried product with a solvent capable of dissolving nobiletin and tangeretin to obtain a nobiletin and tangeretin solution; (3) a step of concentrating and/or drying the nobiletin and tangeretin solution to obtain a nobiletin and tangeretin concentrate; and (4) a step of treating the nobiletin and tangeretin concentrate with a dilute alkali to obtain a composition containing nobiletin and tangeretin as an insoluble component, and by a composition containing nobiletin and tangeretin at high concentrations manufactured by the method.

    摘要翻译： 本发明的目的是提供一种制造以高浓度含有川皮苷和橘皮一个级分的方法，所有这些都具有优异的安全性，经济性，以及用于工业化的潜力方面。 该目的是通过制备含有川皮苷和橘皮（1-1）的组合物，包括处理柑橘类水果用热水以获得热水处理的产品的步骤的方法来实现; （1-2）干燥所述热水处理的产物，以获得干燥的产物的步骤; （1-3）与能够溶解和川皮苷橘皮以获得川皮苷和橘皮溶液的溶剂处理所述干燥的产物的步骤; （3）浓缩和/或干燥所述川皮苷和橘皮溶液中以获得川皮苷和橘皮浓缩物的步骤; 和（4）处理所述川皮苷和橘皮的步骤集中用稀碱，得到的组合物含有川皮苷和橘皮，以不溶性成分，并通过在由该方法制造高浓度含有川皮苷和橘皮的组合物。

    METHOD FOR PRODUCING NEPODIN-RICH EXTRACT OF RUMEX PLANT AND NEPODIN-RICH EXTRACT OF RUMEX PLANT
    2.
    发明公开
    METHOD FOR PRODUCING NEPODIN-RICH EXTRACT OF RUMEX PLANT AND NEPODIN-RICH EXTRACT OF RUMEX PLANT 审中-公开

    公开(公告)号：EP3437648A1

    公开(公告)日：2019-02-06

    申请号：EP17773859.8

    申请日：2017-02-21

    申请人： Okinawa Research Center Co. Ltd. ,  University of The Ryukyus

    发明人： WOO, Je-Tae ,  TERUYA, Yuto ,  SASAKI, Kozue ,  TERUYA, Toshiaki ,  YAMANO, Aki ,  SUEYOSHI, Kosuke ,  YAMADA, Miki

    IPC分类号： A61K36/70 ,  A61K31/12

    摘要： An objective of the present invention is to provide a method for producing a nepodin-containing extract containing a high concentration of nepodin with less contaminants present therein thereby being able to be readily carried out on an industrial scale, when compared to the conventional techniques. The objective is solved by A method for producing a nepodin-containing Rumex plant extract, the method comprising the following steps (1) to (5):
    (1) a step of subjecting a Rumex plant to an extraction treatment using a nepodin-dissolving solvent to obtain a crude Rumex plant extract;
    (2) a step of subjecting the crude Rumex plant extract to a water-adding treatment and/or concentration treatment to obtain a solid crude Rumex plant extract;
    (3) a step of subjecting the solid crude Rumex plant extract to a weak alkali treatment to obtain a weak alkali insoluble product;
    (4) a step of subjecting the weak alkali insoluble product to a strong alkali treatment to obtain a strong alkali soluble product; and
    (5) a step of subjecting the strong alkali soluble product to a neutralization treatment to obtain the nepodin-containing Rumex plant extract.