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    METHODS, SYSTEMS, AND APPARATUS FOR REDUCING THE FREQUENCY AND/OR SEVERITY OF PHOTOPHOBIC RESPONSES OR FOR MODULATING CIRCADIAN CYCLES
    1.
    发明公开
    METHODS, SYSTEMS, AND APPARATUS FOR REDUCING THE FREQUENCY AND/OR SEVERITY OF PHOTOPHOBIC RESPONSES OR FOR MODULATING CIRCADIAN CYCLES 审中-公开
    方法，系统和设备用于降低频率和/或程度严重PHOTOPHOBER反应或调制昼夜周期

    公开(公告)号：EP3171939A1

    公开(公告)日：2017-05-31

    申请号：EP15748360.3

    申请日：2015-07-22

    申请人： University of Utah Research Foundation

    发明人： BLAIR, Steven M. ,  KATZ, Bradley Jay

    IPC分类号： A61N5/00 ,  B82Y40/00 ,  G02B5/20 ,  G02B5/28 ,  G02C7/10

    CPC分类号： G02C7/104 ,  A61N5/0618 ,  A61N2005/0648 ,  A61N2005/0662 ,  A61N2005/0667 ,  B82Y20/00 ,  G02B5/206 ,  G02B5/207 ,  G02B5/28 ,  G02B5/289

    摘要： An optical filter may reduce the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to cells in the human eye in certain wavelengths, such as 480nm and 590nm, and a visual spectral response of the human eye. The optical filter may disrupt the isomerization of melanopsin in the human eye reducing the availability of the active isoform, whereas the attenuation of light weighted across the action potential spectrum of the active isoform attenuates the phototransduction cascade leading to photophobic responses. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light in certain wavelengths, and to transmit more than a second amount of light weighted across the visual spectral response. Methods of use and methods of manufacturing optical filters are also described.

    摘要翻译： 的滤光器可以减少频率和/或避光的反应严重性或通过控制光照射细胞对人眼在某些波长，：如480纳米和590纳米，以及人眼的视觉光谱响应调制昼夜周期。 滤光器可以扰乱人眼减少活性同种型的可用性黑视蛋白的异构化，尽管光在活性同种型的动作电位的频谱加权的衰减衰减光传导级联，导致避光响应。 的滤光器的实施方式进行说明。 在滤光器的一个实施例可以被配置为传送小于特定波长的光的第一量，和传送比跨过视觉光谱响应加权的光的第二量更多。 因此，使用方法和制造滤光器的方法进行了描述。

    APPARATUS AND METHODS FOR REDUCING FREQUENCY OR SEVERITY OF PHOTOPHOBIC RESPONSES OR MODULATING CIRCADIAN CYCLES
    4.
    发明公开
    APPARATUS AND METHODS FOR REDUCING FREQUENCY OR SEVERITY OF PHOTOPHOBIC RESPONSES OR MODULATING CIRCADIAN CYCLES 审中-公开

    公开(公告)号：EP4245347A2

    公开(公告)日：2023-09-20

    申请号：EP23189866.9

    申请日：2012-01-17

    申请人： University of Utah Research Foundation

    发明人： BLAIR, Steven M. ,  KATZ, Bradley, Jay

    IPC分类号： A61M21/00

    摘要： The present disclosure describes systems, methods, and apparatus for reducing the frequency and/or severity of photophobic responses or for modulating circadian cycles by controlling light exposure to melanopsin ganglion cells in a retina over the action potential spectrum of the melanopsin cells of the human eye and a visual spectral response of the human eye. Embodiments of an optical filter are described. In one embodiment an optical filter may be configured to transmit less than a first amount of light weighted across the action potential spectrum of the melanopsin cells and to transmit more than a second amount of light weighted across the visual spectral response. Methods of manufacturing optical filters are also described.