公开(公告)号：EP4328319A3

公开(公告)日：2024-08-07

申请号：EP23200884.7

申请日：2017-10-27

申请人： University of Utah Research Foundation

发明人： Oliver, Trudy ,  Sos, Martin ,  Wechsler-Reya, Rob

IPC分类号： A01K67/027 ,  C12N15/09 ,  C12Q1/02 ,  A01K67/0278 ,  A61P35/00 ,  A61P43/00 ,  C12Q1/6886 ,  G01N33/574

CPC分类号： G01N33/57423 ,  G01N2800/5220130101 ,  C12Q1/6886 ,  C12Q2600/10620130101 ,  C12Q2600/11220130101 ,  C12Q2600/15820130101 ,  A01K67/0278 ,  A01K2217/07220130101 ,  A01K2217/07520130101 ,  A01K2217/20620130101 ,  A01K2227/10520130101 ,  A01K2267/033120130101 ,  C12N2999/00720130101 ,  A61P35/00 ,  A61P43/00

摘要： Described herein are methods and compositions useful in detecting, diagnosing and treating small cell lung cancer. Transgenic animal models and cell lines are disclosed for the study of a small cell lung cancer subtype. Methods of screening and identifying active agents for the treatment of a small cell lung cancer subtype as well as methods of identifying patients susceptible to treatment with aurora kinase inhibitors are also provided.

公开(公告)号：EP4328319A2

公开(公告)日：2024-02-28

申请号：EP23200884.7

申请日：2017-10-27

申请人： University of Utah Research Foundation

发明人： Oliver, Trudy ,  Sos, Martin ,  Wechsler-Reya, Rob

IPC分类号： C12Q1/02

摘要： Described herein are methods and compositions useful in detecting, diagnosing and treating small cell lung cancer. Transgenic animal models and cell lines are disclosed for the study of a small cell lung cancer subtype. Methods of screening and identifying active agents for the treatment of a small cell lung cancer subtype as well as methods of identifying patients susceptible to treatment with aurora kinase inhibitors are also provided.