公开(公告)号：EP3179914A1

公开(公告)日：2017-06-21

申请号：EP15832438.4

申请日：2015-08-14

申请人： The University of Virginia Patent Foundation

发明人： FACCHINETTI, Andrea ,  SPARACINO, Giovanni ,  COBELLI, Claudio ,  KOVATCHEV, Boris P.

IPC分类号： A61B5/145 ,  G06F19/00

CPC分类号： A61B5/14532 ,  A61B5/1495 ,  A61B5/725 ,  A61B5/7275 ,  G06F19/00

摘要： A method, system, and device for improving the accuracy of a continuous glucose monitoring sensor by estimating a CGM signal at a time t+PH using a value of CGM at time t, using a real-time short-time glucose prediction horizon to estimate the real time denoised CGM value with a noise estimation algorithm.

摘要翻译： 一种通过使用实时短时葡萄糖预测水平来估计在时间t时利用CGM的值在时间t + PH处的CGM信号来提高连续葡萄糖监测传感器的准确度的方法，系统和设备 用噪声估计算法实时去噪CGM值。

公开(公告)号：EP3017389A2

公开(公告)日：2016-05-11

申请号：EP14819899.7

申请日：2014-07-03

申请人： University of Virginia Patent Foundation

发明人： BRETON, Marc D. ,  KOVATCHEV, Boris P. ,  DALLA MAN, Chiara ,  COBELLI, Claudio ,  MICHELETTO, Francesco

IPC分类号： G06F19/18

CPC分类号： G06F19/702 ,  G06F19/00 ,  G16H50/50

摘要： A simulator for in-silico testing of Type 1 diabetes patients uses a model that puts in relation plasma concentrations, i.e., glucose G and insulin /, with glucose fluxes, i.e. endogenous glucose production (EGP), glucose rate of appearance (Ra), glucose utilization by the tissues (U), renal extraction (E), and insulin fluxes, i.e., rate of insulin appearance from the subcutaneous tissues (SC) and insulin degradation (D). A module is also included to describe counter-regulation, i.e. glucagon kinetics, secretion and action. A glucagon subcutaneous absorption model enables simulation of dual hormone control.

公开(公告)号：EP2470256A1

公开(公告)日：2012-07-04

申请号：EP10814378.5

申请日：2010-08-31

申请人： University Of Virginia Patent Foundation

发明人： KOVATCHEV, Boris, P. ,  DE NICOLAO, Giuseppe ,  MAGNI, Lalo ,  DALLA MAN, Chiara ,  COBELLI, Claudio

IPC分类号： A61M31/00

CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/4839 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H50/50

摘要： A method, system and computer program product for correcting a nominal treatment strategy of a subject with diabetes. The method, system and computer program product may be configured for providing input whereby the input may include: open-loop therapy settings for the subject, data about glycemic state of the subject; and (optionally) data about meals and/or exercise of the subject. The method, system and computer program product may be configured for providing output, whereby the out-put may include an adjustment (correction) to the open-loop therapy settings for the subject for insulin delivery to the subject.

公开(公告)号：EP2446261A1

公开(公告)日：2012-05-02

申请号：EP10792764.2

申请日：2010-06-25

申请人： University Of Virginia Patent Foundation

发明人： KOVATCHEV, Boris P. ,  COBELLI, Claudio ,  DALLA MAN, Chiara

IPC分类号： G01N33/48

CPC分类号： G16H50/50 ,  G06F19/00

摘要： An electronic system is provided that simulates a glucose-insulin metabolic system of a T2DM or prediabetic subject, wherein the system includes a subsystem that models dynamic glucose concentration in a T2DM or prediabetic subject, including an electronic module that models endogenous glucose production (EGP(t)), or meal glucose rate of appearance (Ra(t>>, or glucose utilization (U(t)), or renal excretion of glucose (B(t)), a subsystem that models dynamic insulin concentration in said T2DM or prediabetic subject, including an electronic module that models insulin secretion (S(t)), an electronic database containing a population of virtual T2DM or prediabetic subjects, each virtual subject having a plurality of metabolic parameters, and a processing module that calculates an effect of variation of at least one metabolic parameter value on the glucose insulin metabolic system of a virtual subject by inputting the plurality of metabolic parameter values.

公开(公告)号：EP2203112A1

公开(公告)日：2010-07-07

申请号：EP08780896.0

申请日：2008-06-20

申请人： University Of Virginia Patent Foundation

发明人： KOVATCHEV, Boris, P. ,  BRETON, Marc, D. ,  COBELLI, Claudio ,  DALLA MAN, Chiara

IPC分类号： A61B5/00

摘要： A simulation environment for in silico testing of monitoring methods, open-loop and closed-loop treatment strategies in type 1 diabetes. Some exemplary principal components of the simulation environment comprise, but not limited thereto, the following: 1) a “population” of in silico “subjects” with type 1 diabetes in three age groups; 2) a simulator of CGM sensor errors; 3) a simulator of insulin pumps and discrete insulin delivery; 4) an interface allowing the input of user-specified treatment scenarios; and 5) a set of standardized outcome measures and graphs evaluating the quality of the tested treatment strategies. These components can be used separately or in combination for the preclinical evaluation of open-loop or closed-loop control treatments of diabetes.

公开(公告)号：EP2203112B1

公开(公告)日：2020-03-11

申请号：EP08780896.0

申请日：2008-06-20

申请人： University of Virginia Patent Foundation

发明人： KOVATCHEV, Boris, P. ,  BRETON, Marc, D. ,  COBELLI, Claudio ,  DALLA MAN, Chiara

IPC分类号： G16H50/50