公开(公告)号：EP3199171A1

公开(公告)日：2017-08-02

申请号：EP15842648.6

申请日：2015-09-16

申请人： University-Industry Cooperation Group of Kyung Hee University ,  Dong-A St Co., Ltd.

发明人： KIM, Youngmi ,  OH, Myung Sook ,  HONG, Seon-Pyo ,  SOHN, Mi Won ,  JEONG, Jin Seok ,  JIANG, Hai Hua ,  KIM, Eunjin ,  RYU, Ja Young ,  CHO, Young Woong ,  Du, Xiao Fei ,  CHOI, Sang Zin ,  KIM, Jeong Soo ,  KIM, Byoung Moon

IPC分类号： A61K36/65 ,  A61K36/232 ,  A61K36/233 ,  A61P25/28 ,  A61P25/00

CPC分类号： A61K36/65 ,  A21D13/047 ,  A21D13/40 ,  A23L2/52 ,  A23L7/109 ,  A23L13/422 ,  A23L23/10 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/12 ,  A61K31/352 ,  A61K31/357 ,  A61K31/7048 ,  A61K36/232 ,  A61K36/233 ,  A61K2236/333 ,  A61K2236/51 ,  A61K2236/53

摘要： The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.

摘要翻译： 本发明涉及用于治疗和预防退行性神经疾病的药物组合物，其含有作为活性成分的选自牡丹根皮，当归达胡萝卜根和柴胡根中的两种或更多种的混合物提取物，或 其一部分。 具体而言，本发明混合物的提取物对线粒体功能损伤具有恢复效果，对内质网应激具有缓解作用，并且同时具有对炎症反应的抑制效果，与体外显示的相比，其显着改善 单一提取物和混合物的提取物在帕金森病动物模型中显着地表现出对运动协调的改善效果和对多巴胺能神经元的保护作用，因此，本发明混合物的提取物或其部分可用作 用于治疗和预防退行性神经疾病的药物组合物的活性成分。

公开(公告)号：EP3199171B1

公开(公告)日：2018-12-26

申请号：EP15842648.6

申请日：2015-09-16

申请人： University-Industry Cooperation Group of Kyung Hee University ,  Dong-A St Co., Ltd.

发明人： KIM, Youngmi ,  OH, Myung Sook ,  HONG, Seon-Pyo ,  SOHN, Mi Won ,  JEONG, Jin Seok ,  JIANG, Hai Hua ,  KIM, Eunjin ,  RYU, Ja Young ,  CHO, Young Woong ,  Du, Xiao Fei ,  CHOI, Sang Zin ,  KIM, Jeong Soo ,  KIM, Byoung Moon

IPC分类号： A61K36/65 ,  A61K36/232 ,  A61K36/233 ,  A61P25/28 ,  A61P25/00

CPC分类号： A61K36/65 ,  A21D13/047 ,  A21D13/40 ,  A23L2/52 ,  A23L7/109 ,  A23L13/422 ,  A23L23/10 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A61K31/12 ,  A61K31/352 ,  A61K31/357 ,  A61K31/7048 ,  A61K36/232 ,  A61K36/233 ,  A61K2236/333 ,  A61K2236/51 ,  A61K2236/53

摘要： The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.