公开(公告)号：EP4324326A1

公开(公告)日：2024-02-21

申请号：EP22460037.9

申请日：2022-08-17

申请人： Uniwersytet Jagiellonski

发明人： Kwiatkowski, Grzegorz ,  Chlopicki, Stefan ,  Marczyk, Brygida ,  Bar, Anna

IPC分类号： A01K67/027 ,  A61K31/506

摘要： A method of obtaining a mouse model of diastolic heart failure with preserved ejection fraction, the method comprising administering to mice, a compound which is a tyrosine kinase inhibitor at a dose of at least 1 mg/kg for a period for 2 to 4 weeks, preferably 4 weeks, wherein the age of mice at the start of the administration of the compound is not more than 24 weeks, preferably from 8 to 12 weeks, wherein tyrosine kinase inhibitor is a tyrosine kinase inhibitor having the oncological therapeutic target of BCR-ABL tyrosine kinase*, preferably a compound belonging to the 1st or 2nd or 3rd generation of tyrosine kinase inhibitors for the treatment of chronic myeloid leukaemia (CML).