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1.发明公开
公开(公告)号：EP4443137A1
公开(公告)日：2024-10-09
申请号：EP23461553.2
申请日：2023-04-07
发明人： Majzner, Katarzyna , Adamczyk, Adriana , Nowakowska, Anna , Baranska, Malgorzata , Jakubowska, Justyna , Mlynarski, Wojciech
IPC分类号： G01N21/65 , G01N33/50 , G01N33/543
CPC分类号： G01N21/65 , G01N33/54373 , G01N33/5047 , G01N33/5073
摘要： The invention relates to a new method of identifying differentiation into neutrophils of human promyelocytic leukaemia HL-60 cell line, which is an in vitro model of hematopoietic cells, which involves calculating the ratio of the band intensities characteristic of cytochrome, lipids and MitoBADY reporter, which signal, together with the integrated intensities of lipids and cytochrome bands present in the Raman spectra of living cells, allows for distinguishing between differentiated and undifferentiated cells. The method used in the embodiments to measure the intensity ratio of these bands is Raman spectroscopy.
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公开(公告)号：EP4399727A1
公开(公告)日：2024-07-17
申请号：EP22812841.9
申请日：2022-10-03
发明人： BAKIERSKA, Monika , KUBICKA, Marcelina , MOLENDA, Marcin , BIELEWSKI, Jakub , CHUDZIK, Krystian
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3.发明公开
公开(公告)号：EP4324326A1
公开(公告)日：2024-02-21
申请号：EP22460037.9
申请日：2022-08-17
IPC分类号： A01K67/027 , A61K31/506
摘要： A method of obtaining a mouse model of diastolic heart failure with preserved ejection fraction, the method comprising administering to mice, a compound which is a tyrosine kinase inhibitor at a dose of at least 1 mg/kg for a period for 2 to 4 weeks, preferably 4 weeks, wherein the age of mice at the start of the administration of the compound is not more than 24 weeks, preferably from 8 to 12 weeks, wherein tyrosine kinase inhibitor is a tyrosine kinase inhibitor having the oncological therapeutic target of BCR-ABL tyrosine kinase*, preferably a compound belonging to the 1st or 2nd or 3rd generation of tyrosine kinase inhibitors for the treatment of chronic myeloid leukaemia (CML).
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公开(公告)号：EP4298115A1
公开(公告)日：2024-01-03
申请号：EP22710452.8
申请日：2022-02-24
发明人： HEDDLE, Jonathan , AZUMA, Yusuke , NASKALSKA, Antonina , BORZ CKA-SOLARZ, Kinga , RÓZYCKI, Jan , GAWE , Szymon
IPC分类号： C07K14/195 , C07K1/13
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5.发明公开
公开(公告)号：EP4204028A1
公开(公告)日：2023-07-05
申请号：EP21799130.6
申请日：2021-08-26
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公开(公告)号：EP4148130A1
公开(公告)日：2023-03-15
申请号：EP21461586.6
申请日：2021-09-09
发明人： Heddle, Jonathan , Sakai, Yusuke , Wilkens, Gerrit
摘要： It has been disclosed a method for the construction of single stranded DNA catenanes at the kilobase length scale, which can be used for the assembling scaffolds of covalently connected DNA origamis.
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公开(公告)号：EP4087651A1
公开(公告)日：2022-11-16
申请号：EP20712065.0
申请日：2020-01-10
发明人： KALVINS, Ivars , CHLOPICKI, Stefan , ANDRIANOV, Victor , STOJAK, Marta , DOMRACEVA, Ilona , KANEPE-LAPSA, Iveta , ZELENCOVA, Diana , WIETRZYK, Joanna , TURLEJ, Eliza , STACHOWICZ, Martyna , JAROSZ, Joanna , MILCZAREK, Magdalena , KRAMKOWSKI, Karol
IPC分类号： A61P7/00 , A61P9/00 , A61P35/00 , C07D203/24 , C07D401/12 , C07D405/12 , A61K31/396
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公开(公告)号：EP4087650A1
公开(公告)日：2022-11-16
申请号：EP20711668.2
申请日：2020-01-10
发明人： CHLOPICKI, Stefan , KALVINS, Ivars , PRZYBOROWSKI, Kamil , STOJAK, Marta , ANDRIANOV, Victor , DOMRACEVA, Ilona , KANEPE-LAPSA, Iveta , ZELENCOVA, Diana , WIETRZYK, Joanna , TURLEJ, Eliza , STACHOWICZ, Martyna , JAROSZ, Joanna , MILCZAREK, Magdalena , KRAMKOWSKI, Karol
IPC分类号： A61P7/00 , A61P9/00 , A61P35/00 , C07D203/24 , C07D401/12 , C07D405/12 , A61K31/396
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公开(公告)号：EP3827076A1
公开(公告)日：2021-06-02
申请号：EP18762920.9
申请日：2018-07-26
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公开(公告)号：EP3788182A1
公开(公告)日：2021-03-10
申请号：EP19714109.6
申请日：2019-03-09
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