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公开(公告)号：EP3645018A1
公开(公告)日：2020-05-06
申请号：EP19712598.2
申请日：2019-03-26
申请人： Ustav organicke chemie a biochemie AV CR, v.v.i. , Masarykova Univerzita , FAKULTNI NEMOCNICE U SV. ANNY V BRNE
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公开(公告)号：EP3380508B1
公开(公告)日：2020-07-22
申请号：EP16781318.7
申请日：2016-10-03
发明人： DVORAK, Petr , KREJCI, Pavel , BALEK, Lukas , EISELLEOVA, Livia , KONECNA, Zaneta , DVORAK, Pavel , BEDNAR, David , BREZOVSKY, Jan , SEBESTOVA, Eva , CHALOUPKOVA, Radka , STEPANKOVA, Veronika , VANACEK, Pavel , PROKOP, Zbynek , DAMBORSKY, Jiri , BOSAKOVA, Michaela
IPC分类号： C07K14/50
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公开(公告)号：EP3380508A1
公开(公告)日：2018-10-03
申请号：EP16781318.7
申请日：2016-10-03
发明人： DVORAK, Petr , KREJCI, Pavel , BALEK, Lukas , EISELLEOVA, Livia , KONECNA, Zaneta , DVORAK, Pavel , BEDNAR, David , BREZOVSKY, Jan , SEBESTOVA, Eva , CHALOUPKOVA, Radka , STEPANKOVA, Veronika , VANACEK, Pavel , PROKOP, Zbynek , DAMBORSKY, Jiri , BOSAKOVA, Michaela
IPC分类号： C07K14/50
摘要： The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.
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4.发明公开METHOD OF DETERMINATION OF DIAGNOSIS AND PROGNOSIS IN PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA AND OLIGONUCLEOTIDES FOR USE IN THIS METHOD 审中-公开METHOD FOR限定与慢性淋巴细胞B细胞白血病和OLIKONUKLEOTIDE患者诊断和预后FOR USE用于该方法
公开(公告)号：EP2462243A2
公开(公告)日：2012-06-13
申请号：EP10762586.5
申请日：2010-08-03
发明人： BRYJA, Vitezslav , KREJCI, Pavel , KAUCKA, Marketa , POSPISILOVA, Sarka , MAYER, Jiri , KOZUBIK, Alois , PLEVOVA, Karla , KOTASKOVA, Jana
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , G01N33/5052 , G01N33/5091 , G01N33/57426 , G01N33/577 , G01N33/6842
摘要： The invention provides a method of determination of diagnosis and prognosis of B-cell chronic lymphocytic leukemia from a biological sample collected from the body of a patient, wherein the status of Wnt/PCP signaling pathway is determined. Within the framework of the present invention the relation of CLL and molecular signaling pathway Wnt/PCP the components of which are markedly up-regulated in B-lymphocytes of the patients suffering from CLL was identified. The status of the Wnt/PCP signaling pathway can be determined, e.g., by the determination of the expression of components of said signaling pathway or by the determination of migration of CLL cells in the gradient of a chemokine in the presence of the ligand of said signaling pathway. The invention also relates to suitable oligonucleotides for use in the method of determination of expression of the signaling pathway components.
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