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公开(公告)号:EP2467377A4
公开(公告)日:2013-01-02
申请号:EP10810563
申请日:2010-08-18
发明人: HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , LYSSIKATOS JOSEPH P , NEWHOUSE BRAD , YANG HONG WOON
IPC分类号: C07D401/14 , A61K31/4025 , A61K31/454 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D403/10
CPC分类号: A61K31/55 , C07D223/14 , C07D223/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/04 , C07D405/10
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公开(公告)号:EP2467380A4
公开(公告)日:2013-01-02
申请号:EP10810564
申请日:2010-08-18
发明人: HOWBERT JAMES JEFFRY , DIETSCH GREGORY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY C TODD , GRONEBERG ROBERT D , JONES ZACHARY
IPC分类号: C07D403/10 , A61K31/4025 , A61K31/55 , A61P31/00 , A61P35/00 , C07D223/14 , C07D401/14 , C07D403/14
CPC分类号: C07D223/16 , A61K31/4025 , A61K31/55 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/14
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公开(公告)号:EP2663555A4
公开(公告)日:2014-07-16
申请号:EP12733896
申请日:2012-01-12
发明人: HOWBERT JAMES JEFFRY , HERSHBERG ROBERT , BURGESS LAURENCE E , DOHERTY GEORGE A , EARY CHARLES TODD , GRONEBERG ROBERT D , JONES ZACHARY , LYSSIKATOS JOSEPH P , YANG HONG WOON
IPC分类号: A61K31/55 , A61P37/00 , C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
CPC分类号: C07D223/16 , C07D243/14 , C07D401/12 , C07D487/04
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公开(公告)号:EP2663550A4
公开(公告)日:2014-07-16
申请号:EP12734770
申请日:2012-01-12
IPC分类号: C07D223/16 , A61K31/55 , A61P29/00 , A61P35/00 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04
CPC分类号: C07D295/192 , A61K31/55 , C07D223/16 , C07D401/04 , C07D403/10 , C07D413/10 , C07D487/04
摘要: Provided are benzazepine derivatives useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The benzazepine derivatives have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.
摘要翻译: 提供的组合物和方法可用于通过Toll样受体TLR7和/或TLR8调节信号传导。 组合物和方法可用于治疗或预防疾病,包括癌症,自身免疫性疾病,纤维化疾病,心血管疾病,感染性疾病,炎症性疾病,移植排斥反应或移植物抗宿主病。
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公开(公告)号:EP2621500A4
公开(公告)日:2014-03-05
申请号:EP11830073
申请日:2011-10-03
发明人: HERSHBERG ROBERT , COUKOS GEORGE , DIETSCH GREGORY , FACCIABENE ANDREA , MANJARREZ KRISTI , RANDALL TRESSA D
IPC分类号: A61K31/55 , A61K9/00 , A61K9/127 , A61K9/48 , A61K31/122 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K47/48 , A61P35/00
CPC分类号: A61K31/55 , A61K9/0019 , A61K9/1271 , A61K31/675 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/6951 , B82Y5/00 , A61K2300/00
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6.METHODS FOR THE TREATMENT OF ALLERGIC DISEASES 有权
标题翻译: VERFAHREN ZUR BEHANDLUNG VON ALLERGIEERKRANKUNGEN公开(公告)号:EP2621499A4
公开(公告)日:2014-04-09
申请号:EP11830072
申请日:2011-10-03
发明人: HERSHBERG ROBERT
CPC分类号: A61K31/55 , A61K9/0043
摘要: The present invention is directed generally to a TLR8 agonist VTX-378, for use in the treatment or prevention of allergic diseases, including allergic rhinitis.
摘要翻译: 本发明一般涉及TLR8激动剂VTX-378,用于治疗或预防过敏性疾病,包括过敏性鼻炎。
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7.METHODS OF ENHANCING ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY 有权
标题翻译: VERFAHREN ZURERHÖHUNGEINERANTIKÖRPERABHÄNGIGENZYTOTOXIZITÄT公开(公告)号:EP2560658A4
公开(公告)日:2014-03-05
申请号:EP11772735
申请日:2011-04-21
发明人: HERSHBERG ROBERT
CPC分类号: A61K31/55 , A61K39/39 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2300/00 , C07K16/2863 , C07K16/2887 , C07K16/3046 , C07K16/32 , C07K2317/21 , C07K2317/24 , C07K2317/732
摘要: The application relates to method of increasing antibody-dependent cellular cytotoxicity in a subject receiving therapeutic monoclonal antibody treatment. In some embodiments, methods are provided for administering to subject to a subject in need thereof a therapeutic antibody in conjunction with an ADCC enhancer molecule.
摘要翻译: 本申请涉及在接受治疗性单克隆抗体治疗的受试者中增加抗体依赖性细胞毒性的方法。 在一些实施方案中,提供了用于施用以使有需要的受试者与ADCC增强子分子结合的治疗性抗体的方法。
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