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1.发明授权AZETIDINECARBOXAMIDE DERIVATIVES FOR TREATING CNS DISORDERS 有权AZETIDINCARBOXAMIDDERIVATE中枢神经系统疾病的治疗
公开(公告)号：EP1049672B1
公开(公告)日：2003-09-17
申请号：EP99902658.6
申请日：1999-01-22
发明人： SHEPHERD, Robin, Gerald , ADAMS, David, Reginald , BODKIN, Corinna, Dagmar , CLIFFE, Ian, Anthony , MANSELL, Howard, Langham , MONCK, Nathaniel, Julius
IPC分类号： C07D205/04 , A61K31/395
CPC分类号： C07D205/04
摘要： A compound of formula (1), wherein: R1 is aryl; R2 is H, alkyl or aryl; and R3 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and the use of the compounds in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.
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2.发明公开PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS 有权PYRROLOINDOLE，并吲哚和AZEPINOINDOLE超过5-HT 2C受体激动剂
公开(公告)号：EP1109813A1
公开(公告)日：2001-06-27
申请号：EP99943091.1
申请日：1999-09-01
发明人： ADAMS, David, Reginald , BENTLEY, Jonathan, Mark , ROFFEY, Jonathan, Richard, Anthony , HAMLYN, Richard, John , GAUR, Suneel , DUNCTON, Matthew, Alexander, James , DAVIDSON, James, Edward, Paul , BICKERDIKE, Michael, John , CLIFFE, Ian, Anthony , MANSELL, Howard, Langham
IPC分类号： C07D487/04 , C07D471/04 , C07D491/14 , A61K31/40
CPC分类号： C07D471/04 , C07D487/04 , C07D491/14
摘要： A chemical compound of formula (I), wherein n is 1, 2 or 3; R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 to R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, or R5 and R6 together form a carbocyclic or heterocyclic ring, and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders, diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.
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3.发明授权PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS 有权PYRROLOINDOLE，并吲哚和AZEPINOINDOLE超过5-HT 2C受体激动剂
公开(公告)号：EP1109813B1
公开(公告)日：2004-08-11
申请号：EP99943091.1
申请日：1999-09-01
发明人： ADAMS, David, Reginald , BENTLEY, Jonathan, Mark , ROFFEY, Jonathan, Richard, Anthony , HAMLYN, Richard, John , GAUR, Suneel , DUNCTON, Matthew, Alexander, James , DAVIDSON, James, Edward, Paul , BICKERDIKE, Michael, John , CLIFFE, Ian, Anthony , MANSELL, Howard, Langham
IPC分类号： C07D487/04 , C07D471/04 , C07D491/14 , A61K31/40
CPC分类号： C07D471/04 , C07D487/04 , C07D491/14
摘要： A chemical compound of formula (I), wherein n is 1, 2 or 3; R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 to R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkylthio, arylthio, alkylsulfoxyl, alkylsulfonyl, arylsulfoxyl, arylsulfonyl, amino, monoalkylamino, dialkylamino, nitro, cyano, carboxaldehyde, alkylcarbonyl, arylcarbonyl, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkoxycarbonylamino, aminocarbonyloxy, monoalkylaminocarbonyloxy, dialkylaminocarbonyloxy, monoalkylaminocarbonylamino and dialkylaminocarbonylamino, or R5 and R6 together form a carbocyclic or heterocyclic ring, and pharmaceutically acceptable salts and prodrugs thereof, and the use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders, diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.
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公开(公告)号：EP1343775A2
公开(公告)日：2003-09-17
申请号：EP01990522.3
申请日：2001-12-06
发明人： ADAMS, David, Reginald , BENTLEY, Jonathan, Mark , DAVIDSON, James, Edward, Paul , DAWSON, Claire, Elizabeth , GEORGE, Ashley, Roger , MANSELL, Howard, Langham , MATTEI, Patrizio , MIZRAHI, Jacques , NETTEKOVEN, Matthias, Heinrich , PRATT, Robert, Mark , ROFFEY, Jonathan, Richard, Anthony , ROEVER, Stephan , SPECKLIN, Jean-Luc , STALDER, Henri , WILKINSON, Kerry
IPC分类号： C07D295/20 , A61K31/495 , A61P3/04 , C07D261/08 , C07D213/30
CPC分类号： C07D207/325 , C07D213/30 , C07D213/64 , C07D213/643 , C07D261/08 , C07D277/24 , C07D285/14 , C07D295/205 , C07D295/21 , C07D307/12 , C07D307/42 , C07D333/16 , C07D413/04
摘要： The present invention refers to chemical compounds of formula (I) as well as pharmaceutically usable salts, solvates and esters thereof, wherein R?1 to 44, A1, A2¿ m and n have the significance given in claim 1. They can be used in the form of pharmaceutically preparations for the treatment or prevention of disorders of the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes, obesity and sleep apnoea.
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公开(公告)号：EP1049672A1
公开(公告)日：2000-11-08
申请号：EP99902658.6
申请日：1999-01-22
发明人： SHEPHERD, Robin, Gerald , ADAMS, David, Reginald , BODKIN, Corinna, Dagmar , CLIFFE, Ian, Anthony , MANSELL, Howard, Langham , MONCK, Nathaniel, Julius
IPC分类号： C07D205/04 , A61K31/395
CPC分类号： C07D205/04
摘要： A compound of formula (1), wherein: R1 is aryl; R2 is H, alkyl or aryl; and R3 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and the use of the compounds in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.
摘要翻译： 式（1）的化合物，其中：R1是芳基; R2是H，烷基或芳基; 和R3是氢或烷基; 其药学上可接受的加合物; 以及这些化合物在治疗中的用途，特别是用于治疗和预防诸如焦虑和癫痫的CNS病症。
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公开(公告)号：EP1343775B1
公开(公告)日：2008-06-04
申请号：EP01990522.3
申请日：2001-12-06
发明人： ADAMS, David, Reginald , BENTLEY, Jonathan, Mark , DAVIDSON, James, Edward, Paul , DAWSON, Claire, Elizabeth , GEORGE, Ashley, Roger , MANSELL, Howard, Langham , MATTEI, Patrizio , MIZRAHI, Jacques , NETTEKOVEN, Matthias, Heinrich , PRATT, Robert, Mark , ROFFEY, Jonathan, Richard, Anthony , ROEVER, Stephan , SPECKLIN, Jean-Luc , STALDER, Henri , HARRISON, Kerry
IPC分类号： C07D295/20 , A61K31/495 , A61P3/04 , C07D261/08 , C07D213/30
CPC分类号： C07D207/325 , C07D213/30 , C07D213/64 , C07D213/643 , C07D261/08 , C07D277/24 , C07D285/14 , C07D295/205 , C07D295/21 , C07D307/12 , C07D307/42 , C07D333/16 , C07D413/04
摘要： The present invention refers to chemical compounds of formula (I) as well as pharmaceutically usable salts, solvates and esters thereof, wherein R?1 to 44, A1, A2¿ m and n have the significance given in claim 1. They can be used in the form of pharmaceutically preparations for the treatment or prevention of disorders of the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes, obesity and sleep apnoea.
摘要翻译： 本发明涉及式（I）的化学化合物及其药学上可用的盐，溶剂合物和酯，其中R 1至44，A 1，A 2和m具有权利要求1中给出的含义。可以使用它们 其为用于治疗或预防中枢神经系统疾病，心血管疾病，胃肠疾病，糖尿病，肥胖症和睡眠呼吸暂停的药物制剂形式。
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7.发明授权AZETIDINECARBOXAMIDE DERIVATIVES FOR TREATING CNS DISORDERS 有权AZETIDINCARBOXAMIDDERIVATE中枢神经系统疾病的治疗
公开(公告)号：EP1049670B1
公开(公告)日：2002-07-17
申请号：EP99901781.7
申请日：1999-01-22
发明人： SHEPHERD, Robin, Gerald , ADAMS, David, Reginald , BENTLEY, Jon , BODKIN, Corinna, Dagmar , CLIFFE, Ian, Anthony , DAVIDSON, James, Edward, Paul , MANSELL, Howard, Langham , MONCK, Nathaniel, Julius
IPC分类号： C07D205/04 , A61K31/395
CPC分类号： C07D205/04
摘要： A compound of formula (1), wherein R1 is aryl; and R2 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and their use in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.
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8.发明公开AZETIDINECARBOXAMIDE DERIVATIVES FOR TREATING CNS DISORDERS 有权AZETIDINCARBOXAMIDDERIVATE中枢神经系统疾病的治疗
公开(公告)号：EP1049670A1
公开(公告)日：2000-11-08
申请号：EP99901781.7
申请日：1999-01-22
发明人： SHEPHERD, Robin, Gerald , ADAMS, David, Reginald , BENTLEY, Jon , BODKIN, Corinna, Dagmar , CLIFFE, Ian, Anthony , DAVIDSON, James, Edward, Paul , MANSELL, Howard, Langham , MONCK, Nathaniel, Julius
IPC分类号： C07D205/04 , A61K31/395
CPC分类号： C07D205/04
摘要： A compound of formula (1), wherein R1 is aryl; and R2 is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and their use in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.
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