公开(公告)号：EP3411080A2

公开(公告)日：2018-12-12

申请号：EP17748078.7

申请日：2017-02-01

Applicant: Arrakis Therapeutics, Inc.

Inventor： PETTER, Russell, C. ,  BARSOUM, James, Gregory ,  KUBICA, Neil

IPC: A61K48/00 ,  C07H21/04

CPC classification number: C07H21/02 ,  C07C233/15 ,  C07C233/78 ,  C07C237/04 ,  C07C2603/86 ,  C07D207/16 ,  C07D213/30 ,  C07D213/38 ,  C07D215/18 ,  C07D215/48 ,  C07D221/22 ,  C07D231/12 ,  C07D233/64 ,  C07D249/06 ,  C07D307/42 ,  C07D307/52 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D487/04 ,  C07D519/00 ,  C07H5/06 ,  C07H13/04

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

公开(公告)号：EP2720539B1

公开(公告)日：2018-10-24

申请号：EP12800198.9

申请日：2012-06-13

Applicant: Bikam Pharmaceuticals, Inc.

Inventor： GARVEY, David, S.

IPC: C07C255/53 ,  C07C259/18 ,  C07C33/14 ,  C07C33/34 ,  C07C33/50 ,  C07D333/16 ,  C07D333/22 ,  C07C43/23 ,  C07C49/792 ,  C07C49/813 ,  C07C49/84 ,  C07D307/42 ,  C07D307/46 ,  C07C255/56

CPC classification number: C07D333/22 ,  A61K31/045 ,  A61K31/12 ,  A61K31/277 ,  C07C25/06 ,  C07C25/13 ,  C07C25/18 ,  C07C33/14 ,  C07C33/34 ,  C07C33/50 ,  C07C43/23 ,  C07C49/792 ,  C07C49/813 ,  C07C49/84 ,  C07C255/53 ,  C07C255/56 ,  C07C259/18 ,  C07C2601/14 ,  C07C2601/16 ,  C07D307/42 ,  C07D307/46 ,  C07D333/16

Abstract: Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

公开(公告)号：EP2712367B1

公开(公告)日：2018-09-26

申请号：EP12776629.3

申请日：2012-04-19

Applicant: University Of Southern California

Inventor： PRAKASH, G.K. Surya ,  JOG, Parag V. ,  BATAMACK, Patrice T.D. ,  OLAH, George A.

IPC: C07B39/00 ,  C07C17/269 ,  C07C17/32 ,  C07C201/12 ,  C07C29/40 ,  C07C29/62 ,  C07C29/72 ,  C07C303/16 ,  C07C41/01 ,  C07C41/30 ,  C07C41/50 ,  C07C45/45 ,  C07D213/26 ,  C07D307/42 ,  C07D307/44 ,  C07F7/08

CPC classification number: C07D307/44 ,  C07B39/00 ,  C07C17/269 ,  C07C17/32 ,  C07C29/40 ,  C07C29/62 ,  C07C41/01 ,  C07C41/30 ,  C07C41/50 ,  C07C45/455 ,  C07C201/12 ,  C07C303/16 ,  C07C2603/24 ,  C07D213/26 ,  C07D307/42 ,  C07F7/081 ,  C07F7/0896 ,  C07C22/08 ,  C07C205/26 ,  C07C205/11 ,  C07C205/37 ,  C07C309/06 ,  C07C33/46 ,  C07C43/23 ,  C07C33/486 ,  C07C49/80 ,  C07C43/317 ,  C07C43/225

Abstract: A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur.

公开(公告)号：EP3004043B1

公开(公告)日：2018-01-31

申请号：EP14727003.7

申请日：2014-05-29

Applicant: Syngenta Limited

Inventor： BLACK, Janice ,  SCUTT, James, Nicholas ,  WHALLEY, Louisa ,  WILLETS, Nigel, James

IPC: A01N43/16 ,  A01N43/18 ,  A01N43/40 ,  C07D307/42 ,  C07C323/22 ,  C07D309/32 ,  A01N35/06 ,  C07D311/96 ,  C07D493/08 ,  C07C49/753

CPC classification number: C07D493/08 ,  A01N35/06 ,  A01N37/02 ,  A01N37/10 ,  A01N43/16 ,  A01N43/18 ,  A01N43/40 ,  A01N43/90 ,  A01N47/06 ,  C07C49/517 ,  C07C49/577 ,  C07C49/753 ,  C07C69/24 ,  C07C69/78 ,  C07C69/96 ,  C07C323/22 ,  C07C381/14 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2602/44 ,  C07D307/42 ,  C07D309/32 ,  C07D311/96

Abstract: The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R1 is fluorine or bromine; R2 is ethynyl, C1-C3alkoxy, C1-C3haloalkoxy, or C1-C3alkoxy-C1-C3alkoxy-; and Q is a pyran-3,5-dione-4-yl, a thiopyran-3,5-dione-4-yl, a piperidine-3,5-dione-4-yl, a cyclopentane-1,3-dione-2-yl, a cyclohexane-1,3, 5-trione-2-yl, a cyclohexane-1,3-dione-2-yl, or a cycloheptane-1,3-dione-2-yl, or a derivative thereof (e.g. a fused such as fused bicyclic derivative, and/or a spirocyclic derivative), or an enol ketone tautomer derivative thereof, wherein Q is further defined herein; and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. Preferably, X is methyl; and/or R1 is fluorine; and/or R2 is —O—R2A, wherein R2A is methyl, ethyl, trifluoromethyl, difluoromethyl, trifluoroethyl, or —CH2CH2OCH3. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the weeds and/or to the plants and/or to the locus thereof.

公开(公告)号：EP2838520B1

公开(公告)日：2017-12-13

申请号：EP13736632.4

申请日：2013-04-17

Applicant: University College Dublin National University Of Ireland, Dublin

Inventor： KINSELLA, Therese, B. ,  GUIRY, Patrick ,  REID, Helen ,  O'CONNOR, Barry

IPC: A61K31/00 ,  A61K31/18 ,  A61K31/216 ,  A61K31/44 ,  A61P7/02 ,  C07D213/71 ,  C07D213/89 ,  C07C311/54

CPC classification number: C07D213/71 ,  A61K31/18 ,  A61K31/215 ,  A61K31/64 ,  C07C311/58 ,  C07C311/59 ,  C07C2601/14 ,  C07D205/04 ,  C07D213/34 ,  C07D213/53 ,  C07D213/85 ,  C07D213/89 ,  C07D231/12 ,  C07D261/08 ,  C07D263/48 ,  C07D277/34 ,  C07D295/192 ,  C07D305/08 ,  C07D307/42 ,  C07D307/52 ,  A61K2300/00

Abstract: The invention generally relates to compounds that function as TP antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group. In some embodiments, the invention provides a method of treating thrombosis by administering an antithrombotic compound that preferentially binds to a thromboxane receptor, has preferential binding for either TPalpha (TPα) or TPbeta (TP&bgr;) receptor subtype.

公开(公告)号：EP1451133B1

公开(公告)日：2017-10-25

申请号：EP02803182.1

申请日：2002-11-08

Applicant: THE PENN STATE RESEARCH FOUNDATION

Inventor： ZHANG, Xumu ,  TANG, Wenjun

IPC: C07C1/00

CPC classification number: C07F17/02 ,  C07B31/00 ,  C07B53/00 ,  C07B2200/07 ,  C07C5/333 ,  C07C41/20 ,  C07C45/505 ,  C07C45/69 ,  C07C45/72 ,  C07C51/36 ,  C07C67/283 ,  C07C67/303 ,  C07C231/18 ,  C07C2531/24 ,  C07D217/04 ,  C07D307/42 ,  C07D333/24 ,  C07F1/005 ,  C07F7/006 ,  C07F9/005 ,  C07F9/6568 ,  C07F9/65683 ,  C07F9/65685 ,  C07F9/6571 ,  C07F9/657163 ,  C07F9/6584 ,  C07F11/005 ,  C07F13/005 ,  C07F15/0033 ,  C07F15/004 ,  C07F15/0046 ,  C07F15/0053 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/0073 ,  C07F15/008 ,  C07F15/0086 ,  C07F15/0093 ,  C07F15/04 ,  C07F15/045 ,  C07C15/12 ,  C07C55/02 ,  C07C69/007 ,  C07C69/616 ,  C07C69/734 ,  C07C69/34 ,  C07C69/65 ,  C07C69/612 ,  C07C233/47 ,  C07C69/157 ,  C07C69/63 ,  C07C43/205

公开(公告)号：EP3186236A1

公开(公告)日：2017-07-05

申请号：EP15835405.0

申请日：2015-08-27

Applicant: Micromidas, Inc.

Inventor： WOOD, Alex B. ,  MASUNO, Makoto Nathanael ,  SMITH, Ryan L. ,  BISSELL, John Albert II ,  ARAIZA, Robert Joseph ,  HIRSCH-WEIL, Dimitri A.

IPC: C07D307/48

CPC classification number: C07C211/51 ,  C07C205/04 ,  C07C209/32 ,  C07C211/09 ,  C07C211/27 ,  C07C255/35 ,  C07C2601/16 ,  C07D307/14 ,  C07D307/38 ,  C07D307/42 ,  C07D307/52 ,  C07D307/54 ,  C08F210/02 ,  C08G69/04 ,  C08G69/08 ,  C08G69/26 ,  C08G69/28 ,  C08G73/02

Abstract: Provided herein are (phenylene)dialkanamines, and methods of producing such (phenylene)dialkanamines from various furanyl and benzyl compounds. Such furanyl compounds may include, for example, bis(nitroalkyl)furans, bis(aminoalkyl)furans, and nitroalkyl(furan)acetonitriles. Such compounds may include, for example, bis(nitroalkyl)benzenes. Provided herein are also alkyldiamines, and methods for producing such alkyldiamines from furanyl compounds.

Abstract translation: 本文提供（亚苯基）二烷胺，以及由各种呋喃基和苄基化合物制备这种（亚苯基）二烷基胺的方法。 这种呋喃基化合物可以包括例如双（硝基烷基）呋喃，双（氨基烷基）呋喃和硝基烷基（呋喃）乙腈。 这样的化合物可以包括例如双（硝基烷基）苯。 本文还提供了烷基二胺，以及由呋喃基化合物制备这些烷基二胺的方法。

公开(公告)号：EP2760818B8

公开(公告)日：2017-01-11

申请号：EP12780301.3

申请日：2012-09-28

Applicant: Furanix Technologies B.V. ,  Stichting Wageningen Research

Inventor： DAM, Matheus Adrianus ,  DE JONG, Edserd ,  VAN HAVEREN, Jacco ,  PUKIN, Aliaksei

IPC: C07C51/285 ,  C07C51/41 ,  C07D493/18 ,  C07C51/275 ,  C07D307/42

CPC classification number: C07C51/41 ,  C07C51/16 ,  C07C51/275 ,  C07C51/285 ,  C07C51/412 ,  C07D307/42 ,  C07D493/18 ,  C07C65/21 ,  C07C63/307

公开(公告)号：EP3070083A1

公开(公告)日：2016-09-21

申请号：EP15159936.2

申请日：2015-03-19

Applicant: Ludwig-Maximilians-Universität München

Inventor： Knochel, Paul ,  Ellwart, Mario

IPC: C07D333/22 ,  C07B37/04 ,  C07B53/00 ,  C07F17/02 ,  C07F3/06 ,  C07D213/14 ,  C07D213/16 ,  C07F7/18 ,  C07D307/42

CPC classification number: C07F3/06 ,  C07B37/04 ,  C07B53/00 ,  C07B2200/07 ,  C07C1/325 ,  C07C17/263 ,  C07C29/40 ,  C07C43/215 ,  C07C43/30 ,  C07C45/455 ,  C07C67/343 ,  C07C2601/02 ,  C07C2601/10 ,  C07C2601/16 ,  C07C2602/42 ,  C07D213/127 ,  C07D213/14 ,  C07D213/16 ,  C07D307/42 ,  C07D333/22 ,  C07F7/1856 ,  C07F17/02 ,  C07C69/753 ,  C07C33/50 ,  C07C33/14 ,  C07C33/483 ,  C07C69/74 ,  C07C49/813 ,  C07C49/807 ,  C07C49/84 ,  C07C69/757 ,  C07C22/08 ,  C07C25/13 ,  C07C15/44

Abstract: Provided is an organozinc composition comprising (a) an organozinc complex carrying an allylic ligand, (b) a magnesium component and (c) a lithium component. The organozinc composition is useful as a synthetic intermediate with excellent reactivity and selectivity, and can be stored for extended periods of time without loss of activity. Moreover, a process for the preparation of the organozinc composition and synthetic procedures making use of the organozinc composition are provided.

Abstract translation: 提供了一种有机锌组合物，其包含（a）带有烯丙基配体的有机锌络合物，（b）镁组分和（c）锂组分。 有机锌组合物可用作具有优异的反应性和选择性的合成中间体，并且可以长时间储存​​而不损失活性。 此外，提供了使用有机锌组合物制备有机锌组合物和合成方法的方法。

公开(公告)号：EP2760818B1

公开(公告)日：2016-09-14

申请号：EP12780301.3

申请日：2012-09-28

Applicant: Furanix Technologies B.V. ,  Stichting Dienst Landbouwkundig Onderzoek

Inventor： DAM, Matheus Adrianus ,  DE JONG, Edserd ,  VAN HAVEREN, Jacco ,  PUKIN, Aliaksei

IPC: C07C51/285 ,  C07C51/41 ,  C07D493/18 ,  C07C51/275 ,  C07D307/42

CPC classification number: C07C51/41 ,  C07C51/16 ,  C07C51/275 ,  C07C51/285 ,  C07C51/412 ,  C07D307/42 ,  C07D493/18 ,  C07C65/21 ,  C07C63/307