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公开(公告)号：EP1784393B1
公开(公告)日：2009-07-01
申请号：EP05807734.8
申请日：2005-08-31
发明人： WILSON, Dean, M. , TERMIN, Andreas, P. , GONZALEZ, Jesus, E., III , FANNING, Lev, T., D. , NEUBERT, Timothy, D. , KRENITSKY, Paul , JOSHI, Pramod , HURLEY, Dennis, J. , SHETH, Urvi , BOGER, Joshua, S.
IPC分类号： C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , A61P9/06 , A61P25/00 , A61K31/498
CPC分类号： C07D401/04 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：EP2477991B1
公开(公告)日：2015-04-15
申请号：EP10757544.1
申请日：2010-09-17
发明人： AMBHAIKAR, Narendra, Bhalchandra , BEAR, Brian, Richard , FANNING, Lev, T., D. , HUGHES, Robert , LITTLER, Benjamin
IPC分类号： C07D487/08
CPC分类号： C07D487/08
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公开(公告)号：EP2477991A1
公开(公告)日：2012-07-25
申请号：EP10757544.1
申请日：2010-09-17
发明人： AMBHAIKAR, Narendra, Bhalchandra , BEAR, Brian, Richard , FANNING, Lev, T., D. , HUGHES, Robert , LITTLER, Benjamin
IPC分类号： C07D487/08
CPC分类号： C07D487/08
摘要： The present invention relates to a process for preparing azabicyclic compounds that are useful intermediates for synthesizing pharmaceutical compounds or salts thereof.
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公开(公告)号：EP2349263A2
公开(公告)日：2011-08-03
申请号：EP09822784.6
申请日：2009-10-23
发明人： BINCH, Hayley , FANNING, Lev, T., D. , HURLEY, Dennis , SHETH, Urvi , SILINA, Alina , YANG, Xiaoqing , BOTFIELD, Martyn , GROOTENHUIS, Peter, D.J. , VAN GOOR, Fredrick , NUMA, Mehdi, Michel Djamel
IPC分类号： A61K31/439 , C07D453/04 , C12Q1/02
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1856 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ("CFTR"), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR. (l); or pharmaceutically acceptable salts thereof, wherein: ring A is selected from:
摘要翻译： 本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。 本发明还涉及使用CFTR调节剂治疗疾病的方法。 （升）; 或其药学上可接受的盐，其中：环A选自：
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公开(公告)号：EP1904491A2
公开(公告)日：2008-04-02
申请号：EP06760444.7
申请日：2006-05-26
发明人： WILSON, Dean, M. , TERMIN, Andreas, P. , FANNING, Lev, T., D. , KRENITSKY, Paul , JOSHI, Pramod
IPC分类号： C07D417/04 , A61K31/44 , A61K31/496
CPC分类号： C07D277/38 , C07D285/08 , C07D417/04
摘要： The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：EP1784393A1
公开(公告)日：2007-05-16
申请号：EP05807734.8
申请日：2005-08-31
发明人： WILSON, Dean, M. , TERMIN, Andreas, P. , GONZALEZ, Jesus, E., III , FANNING, Lev, T., D. , NEUBERT, Timothy, D. , KRENITSKY, Paul , JOSHI, Pramod , HURLEY, Dennis, J. , SHETH, Urvi , BOGER, Joshua, S.
IPC分类号： C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , A61P9/06 , A61P25/00 , A61K31/498
CPC分类号： C07D401/04 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14
摘要： The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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