公开(公告)号：EP4225764A1

公开(公告)日：2023-08-16

申请号：EP21814947.4

申请日：2021-10-06

申请人： Vertex Pharmaceuticals Incorporated

发明人： MCCARTNEY, Jason ,  ABELA, Alexander Russell ,  ABRAHAM, Sunny ,  ANDERSON, Corey Don ,  ARUMUGAM, Vijayalaksmi ,  CHAU, Jaclyn ,  CLEMENS, Jeremy ,  CLEVELAND, Thomas ,  COON, Timothy Richard ,  DWIGHT, Timothy A. ,  FANNING, Lev Tyler Dewey ,  FRIEMAN, Bryan A. ,  GROOTENHUIS, Peter ,  GULEVICH, Anton V. ,  HADIDA RUAH, Sara Sabina ,  ISHIHARA, Yoshihiro ,  KHATUYA, Haripada ,  KRENITSKY, Paul ,  MELILLO, Vito ,  MILLER, Mark Thomas ,  PARASELLI, Prasuna ,  PIERRE, Fabrice ,  SILINA, Alina ,  TRAN, Joe A. ,  UY, Johnny ,  VALDEZ, Lino ,  ZHOU, Jinglan

IPC分类号： C07D515/04 ,  A61P43/00 ,  A61K31/519

公开(公告)号：EP4225761A1

公开(公告)日：2023-08-16

申请号：EP21801353.0

申请日：2021-10-06

申请人： Vertex Pharmaceuticals Incorporated

发明人： McCARTNEY, Jason ,  ABELA, Alexander Russell ,  ABRAHAM, Sunny ,  ANDERSON, Corey Don ,  ARUMUGAM, Vijayalaksmi ,  CHAU, Jaclyn ,  CLEMENS, Jeremy ,  CLEVELAND, Thomas ,  COON, Timothy Richard ,  DWIGHT, Timothy A. ,  FRIEMAN, Bryan A. ,  GROOTENHUIS, Peter ,  HADIDA RUAH, Sara Sabina ,  ISHIHARA, Yoshihiro ,  KHATUYA, Haripada ,  KRENITSKY, Paul ,  MILLER, Mark Thomas ,  PARASELLI, Prasuna ,  PIERRE, Fabrice ,  SILINA, Alina ,  TRAN, Joe A. ,  ZHOU, Jinglan

IPC分类号： C07D515/04 ,  A61P43/00 ,  A61K31/519

公开(公告)号：EP3798214A1

公开(公告)日：2021-03-31

申请号：EP20188642.1

申请日：2015-10-06

申请人： Vertex Pharmaceuticals Incorporated

发明人： MILLER, Mark Thomas ,  ANDERSON, Corey ,  ARUMUGAM, Vijayalaksmi ,  BEAR, Brian Richard ,  BINCH, Hayley Marie ,  CLEMENS, Jeremy J. ,  CLEVELAND, Thomas ,  CONROY, Erica ,  COON, Timothy Richard ,  FRIEMAN, Bryan A. ,  GROOTENHUIS, Peter Diederik Jan ,  GROSS, Raymond Stanley ,  HADIDA-RUAH, Sara Sabina ,  KHATUYA, Haripada ,  JOSHI, Pramod Virupax ,  KRENITSKY, Paul John ,  LIN, Chun-Chieh ,  MARELIUS, Gulin Erdogan ,  MELILLO, Vito ,  MCCARTNEY, Jason ,  NICHOLLS, Georgia McGaughey ,  PIERRE, Fabrice Jean Denis ,  SILINA, Alina ,  TERMIN, Andreas P. ,  UY, Johnny ,  ZHOU, Jinglan

IPC分类号： C07D403/12 ,  C07D413/14 ,  C07D213/73 ,  C07D231/20 ,  C07D401/04 ,  C07D235/24 ,  C07D403/10 ,  C07D239/34 ,  C07D407/12 ,  C07D209/18 ,  C07D209/49 ,  C07D213/64 ,  A01N41/06 ,  A61K31/18

摘要： The present invention features a compound of formula I:

or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , R 3 , W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

公开(公告)号：EP2686325B1

公开(公告)日：2016-12-14

申请号：EP12710841.3

申请日：2012-03-13

申请人： Vertex Pharmaceuticals Incorporated

发明人： HADIDA-RUAH, Sara, Sabina ,  BINCH, Hayley, Marie ,  DENINNO, Michael, Paul ,  FANNING, Lev, Tyler Dewey ,  FRIEMAN, Bryan, A. ,  GROOTENHUIS, Peter, Diederik Jan ,  HILGRAF, Nicole ,  JOSHI, Pramod ,  KALLEL, Edward, Adam ,  PONTILLO, Joseph ,  SILINA, Alina ,  SHETH, Urvi, Jagdishbhai ,  HURLEY, Dennis, James ,  ARUMUGAM, Vijayalaksmi ,  MILLER, Mark, Thomas

IPC分类号： C07D498/10 ,  A61K31/424 ,  A61P29/00

CPC分类号： C07D498/10

公开(公告)号：EP4225737A1

公开(公告)日：2023-08-16

申请号：EP21801354.8

申请日：2021-10-06

申请人： Vertex Pharmaceuticals Incorporated

发明人： MCCARTNEY, Jason ,  ABRAHAM, Sunny ,  ANDERSON, Corey Don ,  ARUMUGAM, Vijayalaksmi ,  CHAU, Jaclyn ,  CLEVELAND, Thomas ,  DWIGHT, Timothy A. ,  FRIEMAN, Bryan A. ,  GROOTENHUIS, Peter ,  HADIDA RUAH, Sara Sabina ,  ISHIHARA, Yoshihiro ,  MILLER, Mark Thomas ,  SILINA, Alina ,  ZHOU, Jinglan

IPC分类号： C07D213/72 ,  C07D231/42 ,  C07D241/22 ,  C07D251/24 ,  C07D261/16 ,  C07D263/50 ,  C07D277/52 ,  C07D279/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  A61P43/00 ,  A61K31/415 ,  A61K31/44 ,  A61K31/54

公开(公告)号：EP4159717A1

公开(公告)日：2023-04-05

申请号：EP22194095.0

申请日：2015-10-06

申请人： Vertex Pharmaceuticals Incorporated

发明人： MILLER, Mark Thomas ,  ANDERSON, Corey ,  ARUMUGAM, Vijayalaksmi ,  BEAR, Brian Richard ,  BINCH, Hayley Marie ,  CLEMENS, Jeremy J. ,  CLEVELAND, Thomas ,  CONROY, Erica ,  COON, Timothy Richard ,  FRIEMAN, Bryan A. ,  GROOTENHUIS, Peter Diederik Jan ,  GROSS, Raymond Stanley ,  HADIDA-RUAH, Sara Sabina ,  KHATUYA, Haripada ,  JOSHI, Pramod Virupax ,  KRENITSKY, Paul John ,  LIN, Chun-Chieh ,  MARELIUS, Gulin Erdogan ,  MELILLO, Vito ,  MCCARTNEY, Jason ,  NICHOLLS, Georgia McGaughey ,  PIERRE, Fabrice Jean Denis ,  SILINA, Alina ,  TERMIN, Andreas P. ,  UY, Johnny ,  ZHOU, Jinglan

IPC分类号： C07D209/42 ,  C07D401/12 ,  A61K31/404 ,  A61K31/4439 ,  A61P11/00

摘要： The present invention features a compound of formula I:

or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , R 3 , W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

公开(公告)号：EP3436446A1

公开(公告)日：2019-02-06

申请号：EP17716763.2

申请日：2017-03-31

申请人： Vertex Pharmaceuticals Incorporated

发明人： BEAR, Brian ,  CLEMENS, Jeremy ,  CLEVELAND, Thomas ,  COON, Timothy, Richard ,  GROOTENHUIS, Peter, Diederik Jan ,  FRIEMAN, Bryan, A. ,  HADIDA RUAH, Sara S. ,  KHATUYA, Haripada ,  KRENITSKY, Paul, J. ,  MILLER, Mark, Thomas ,  SILINA, Alina ,  UY, Johnny ,  ZHOU, Jinglan

IPC分类号： C07D401/14 ,  C07D213/82 ,  A61P11/00 ,  A61K31/44

公开(公告)号：EP3203840A1

公开(公告)日：2017-08-16

申请号：EP15849396.5

申请日：2015-10-06

申请人： Vertex Pharmaceuticals Incorporated

发明人： MILLER, Mark Thomas ,  ANDERSON, Corey ,  ARUMUGAM, Vijayalaksmi ,  BEAR, Brian Richard ,  BINCH, Hayley Marie ,  CLEMENS, Jeremy J. ,  CLEVELAND, Thomas ,  CONROY, Erica ,  COON, Timothy Richard ,  FRIEMAN, Bryan A. ,  GROOTENHUIS, Peter Diederik Jan ,  GROSS, Raymond Stanley ,  HADIDA-RUAH, Sara Sabina ,  KHATUYA, Haripada ,  JOSHI, Pramod Virupax ,  KRENITSKY, Paul John ,  LIN, Chun-Chieh ,  MARELIUS, Gulin Erdogan ,  MELILLO, Vito ,  MCCARTNEY, Jason ,  NICHOLLS, Georgia McGaughey ,  PIERRE, Fabrice Jean Denis ,  SILINA, Alina ,  TERMIN, Andreas P. ,  UY, Johnny ,  ZHOU, Jinglan

IPC分类号： A01N41/06 ,  A61K31/18

摘要： The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

摘要翻译： 其中R 1，R 2，R 3，W，X，Y，Z，n，o，p和q如本文所定义，用于治疗CFTR介导的疾病，例如囊性纤维化。 本发明的特征还在于药物组合物，治疗方法及其试剂盒。

公开(公告)号：EP2560651A1

公开(公告)日：2013-02-27

申请号：EP11718598.3

申请日：2011-04-22

申请人： Vertex Pharmaceuticals Incorporated

发明人： VAN GOOR, Fredrick, F. ,  ALARGOVA, Rossitza, Gueorguieva ,  ALCACIO, Tim, Edward ,  BINCH, Hayley, Marie ,  BOTFIELD, Martyn, Curtis ,  FANNING, Lev Tyler, Dewey ,  GROOTENHUIS, Peter Diederik, Jan ,  HURLEY, Dennis, James ,  KADIYALA, Irina, Nikolaevna ,  KAUSHIK, Ritu, Rohit ,  KESHAVARZ-SHOKRI, Ali ,  KRAWIEC, Mariusz ,  LEE, Elaine, Chungmin ,  LUISI, Brian ,  MEDEK, Ales ,  NUMA, Mehdi ,  SHETH, Urvi, Jagdishbhai ,  SILINA, Alina ,  VERWIJS, Marinus, Jacobus ,  YANG, Xiaoqing ,  YOUNG, Christopher Ryan ,  ZAMAN, Noreen, Tasneem ,  ZHANG, Beili ,  ZHANG, Yuegang ,  ZLOKARNIK, Gregor

IPC分类号： A61K31/4704 ,  A61K31/404 ,  A61K31/443

CPC分类号： A61K31/4709 ,  A61K31/404 ,  A61K31/443 ,  A61K31/4704 ,  A61K45/06 ,  C07D405/12 ,  C12Q1/34 ,  G01N2500/04 ,  G01N2500/20 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.(Formula I), (Formula II), (Formula III).

摘要翻译： 本发明涉及药物组合物，其包含式I化合物与式II化合物和/或式III化合物中的一种或两种的组合。 本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化（式I），（式II），（式III）的方法。

公开(公告)号：EP4225765A2

公开(公告)日：2023-08-16

申请号：EP21830544.9

申请日：2021-10-06

申请人： Vertex Pharmaceuticals Incorporated

发明人： McCARTNEY, Jason ,  ABELA, Alexander Russell ,  ABRAHAM, Sunny ,  ANDERSON, Corey Don ,  ARUMUGAM, Vijayalaksmi ,  CHAU, Jaclyn ,  CLEMENS, Jeremy ,  CLEVELAND, Thomas ,  COON, Timothy Richard ,  DWIGHT, Timothy A. ,  FANNING, Lev Tyler Dewey ,  FRIEMAN, Bryan A. ,  GROOTENHUIS, Peter ,  GULEVICH, Anton V. ,  HADIDA RUAH, Sara Sabina ,  ISHIHARA, Yoshihiro ,  KHATUYA, Haripada ,  KRENITSKY, Paul ,  MELILLO, Vito ,  MILLER, Mark Thomas ,  PARASELLI, Prasuna ,  PIERRE, Fabrice ,  SILINA, Alina ,  TRAN, Joe A. ,  UY, Johnny ,  VALDEZ, Lino ,  VICKERS, Troy ,  ZHOU, Jinglan

IPC分类号： C07D515/08 ,  C07D519/00 ,  C07D515/18 ,  A61P11/00 ,  A61K31/529