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1.发明授权INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES 有权c-JUN末端激酶（JNK）AND OTHER蛋白激酶抑制剂
公开(公告)号：EP1373257B9
公开(公告)日：2008-10-15
申请号：EP02725391.3
申请日：2002-03-28
IPC分类号： C07D405/04 , A61K31/506 , C07D239/42 , C07D213/74 , A61K31/4418 , A61P25/00 , A61P37/00 , A61P9/00 , A61P29/00 , C07D417/04 , C07D403/04
CPC分类号： C07D213/74 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12
摘要： The present invention provide a compound of formula I or II:or a pharmaceutically acceptable derivative thereof, wherein R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian proteinkinase involved cell proliferation, cell death and response to extracellular stimuli; and Src-family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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2.发明授权INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES 有权c-JUN末端激酶（JNK）AND OTHER蛋白激酶抑制剂
公开(公告)号：EP1373257B1
公开(公告)日：2007-11-28
申请号：EP02725391.3
申请日：2002-03-28
IPC分类号： C07D405/04 , A61K31/506 , C07D239/42 , C07D213/74 , A61K31/4418 , A61P25/00 , A61P37/00 , A61P9/00 , A61P29/00 , C07D417/04 , C07D403/04
CPC分类号： C07D213/74 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12
摘要： The present invention provide a compound of formula I or II:or a pharmaceutically acceptable derivative thereof, wherein R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian proteinkinase involved cell proliferation, cell death and response to extracellular stimuli; and Src-family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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3.发明公开INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES 有权c-JUN末端激酶（JNK）AND OTHER蛋白激酶抑制剂
公开(公告)号：EP1373257A1
公开(公告)日：2004-01-02
申请号：EP02725391.3
申请日：2002-03-28
IPC分类号： C07D405/04 , A61K31/506 , C07D239/42 , C07D213/74 , A61K31/4418 , A61P25/00 , A61P37/00 , A61P9/00 , A61P29/00 , C07D417/04 , C07D403/04
CPC分类号： C07D213/74 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12
摘要： The present invention provide a compound of formula I or II:or a pharmaceutically acceptable derivative thereof, wherein R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian proteinkinase involved cell proliferation, cell death and response to extracellular stimuli; and Src-family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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