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公开(公告)号：EP1392684A1
公开(公告)日：2004-03-03
申请号：EP02737123.6
申请日：2002-05-23
IPC分类号： C07D417/04 , A61K31/427
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/14 , C07D417/04 , C07D417/14 , C07D487/10 , C07F7/1856 , C07F9/6561
摘要： The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatement of various protein kinase mediated disorders.
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公开(公告)号：EP1086085A1
公开(公告)日：2001-03-28
申请号：EP99927377.4
申请日：1999-06-11
发明人： SALITURO, Francesco , BEMIS, Guy , COCHRAN, John
IPC分类号： C07D217/24 , C07D239/80 , C07D239/96 , A61K31/505 , A61K31/47
CPC分类号： C07D239/96 , C07D217/24 , C07D239/60 , C07D239/80
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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公开(公告)号：EP1392684B1
公开(公告)日：2006-09-13
申请号：EP02737123.6
申请日：2002-05-23
IPC分类号： C07D417/04 , A61K31/427
CPC分类号： C07D405/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/14 , C07D417/04 , C07D417/14 , C07D487/10 , C07F7/1856 , C07F9/6561
摘要： The present invention provides a compound of formula I: or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatement of various protein kinase mediated disorders.
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公开(公告)号：EP1114039A1
公开(公告)日：2001-07-11
申请号：EP99949690.4
申请日：1999-09-16
发明人： SALITURO, Francesco , BEMIS, Guy , COCHRAN, John
IPC分类号： C07D277/48 , A61K31/426 , A61K31/421 , A61K31/4168 , C07D263/48 , C07D233/88
CPC分类号： C07D233/88 , C07D263/48 , C07D277/48
摘要： The present invention provides inhibitors of p38 having general formulae (I and II), wherein: X is selected from O, S, NR or C(R)2; Y is CR or N; Z is CH or N; M is C=O, CHOH, or CH2; n is 0 or 1; Q1 is selected from a 5-6 membered aromatic carbocyclic or heterocyclic ring system, or an 8-10 membered bicyclic ring system comprising aromatic carbocyclic rings, aromatic heterocyclic rings or a combination of an aromatic carbocyclic ring and an aromatic heterocyclic ring, and Q2 is selected from H, CO7R', CON(R')2, or a (C1-c4) branched or straight-chain alkyl optionally containing 1-3 substituents independently selected from A, T-C(O)R', OPO3H2, NR'2, N(R'), OR', CO2R', CON(R')2, or SO2N(R2)2; or a 5-6 membered aromatic carbocyclic or heterocyclic ring system, or an 8-10 membered bicyclic ring system comprising aromatic carbocyclic rings, aromatic heterocyclic rings or a combination of an aromatic carbocyclic ring and an aromatic heterocyclic ring.
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公开(公告)号：EP1077943B1
公开(公告)日：2008-12-17
申请号：EP99920427.4
申请日：1999-05-11
IPC分类号： C07D213/56 , A61K31/44 , C07D213/75 , C07D213/74 , C07D401/06 , C07D213/73
CPC分类号： C07D213/74 , C04B35/01 , C07D213/56 , C07D213/75 , C07D217/22
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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公开(公告)号：EP1546117A2
公开(公告)日：2005-06-29
申请号：EP03788433.5
申请日：2003-08-12
发明人： COCHRAN, John , GREEN, Jeremy , HALE, Michael, R. , LEDFORD, Brian , MALTAIS, François , NANTHAKUMAR, Suganthini
IPC分类号： C07D239/42 , C07D401/12 , C07D409/12 , C07D405/12 , C07D403/12 , C07D213/74 , A61K31/44 , A61K31/4418 , A61K31/505 , A61K31/506 , A61P19/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D213/74 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Described herein are compounds that are useful as protein kinase inhibitors having the formulae (I) and (V) or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2 U, T, m, n, p, Q, Q', R1, R2, Rx, R3, and R6 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
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公开(公告)号：EP1309560A1
公开(公告)日：2003-05-14
申请号：EP01962021.0
申请日：2001-08-10
发明人： COCHRAN, John , GALULLO, Vincent , BEMIS, Guy
IPC分类号： C07D213/75 , C07D401/12 , A61K31/4418 , A61P7/00 , A61P9/00 , A61P17/00 , A61P25/00 , A61P31/00 , C07F9/58
CPC分类号： C07D213/75 , C07D401/12 , C07F9/582 , C07F9/588
摘要： The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to inhibitors of ZAP70. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders. These compounds have the general formula: (Ia), (Ib), (Ic) and (Id).
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公开(公告)号：EP1309560B1
公开(公告)日：2012-10-03
申请号：EP01962021.0
申请日：2001-08-10
发明人： COCHRAN, John , GALULLO, Vincent , BEMIS, Guy
IPC分类号： C07D213/75 , C07D401/12 , A61K31/4418 , A61P7/00 , A61P9/00 , A61P17/00 , A61P25/00 , A61P31/00 , C07F9/58
CPC分类号： C07D213/75 , C07D401/12 , C07F9/582 , C07F9/588
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9.发明授权INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES 有权c-JUN末端激酶（JNK）AND OTHER蛋白激酶抑制剂
公开(公告)号：EP1373257B9
公开(公告)日：2008-10-15
申请号：EP02725391.3
申请日：2002-03-28
IPC分类号： C07D405/04 , A61K31/506 , C07D239/42 , C07D213/74 , A61K31/4418 , A61P25/00 , A61P37/00 , A61P9/00 , A61P29/00 , C07D417/04 , C07D403/04
CPC分类号： C07D213/74 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12
摘要： The present invention provide a compound of formula I or II:or a pharmaceutically acceptable derivative thereof, wherein R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian proteinkinase involved cell proliferation, cell death and response to extracellular stimuli; and Src-family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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10.发明授权INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES 有权c-JUN末端激酶（JNK）AND OTHER蛋白激酶抑制剂
公开(公告)号：EP1373257B1
公开(公告)日：2007-11-28
申请号：EP02725391.3
申请日：2002-03-28
IPC分类号： C07D405/04 , A61K31/506 , C07D239/42 , C07D213/74 , A61K31/4418 , A61P25/00 , A61P37/00 , A61P9/00 , A61P29/00 , C07D417/04 , C07D403/04
CPC分类号： C07D213/74 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/12
摘要： The present invention provide a compound of formula I or II:or a pharmaceutically acceptable derivative thereof, wherein R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian proteinkinase involved cell proliferation, cell death and response to extracellular stimuli; and Src-family kinases, especially Src and Lck kinases. These compounds are also inhibitors of GSK3 and CDK2 kinases. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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