公开(公告)号：EP1389194A2

公开(公告)日：2004-02-18

申请号：EP02725881.3

申请日：2002-04-29

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： BHISETTI, Govinda, R. ,  SAUNDERS, Jeffrey, O. ,  MURCKO, Mark, A. ,  LEPRE, Christopher, A. ,  BRITT, Shawn, D. ,  COME, Jon, H. ,  DENINGER, David, D. ,  WANG, Tianshang

IPC分类号： C07D295/12 ,  C07D215/48 ,  C07D241/04 ,  C07D239/48 ,  C07D211/74 ,  C07D211/82 ,  C07D401/12 ,  C07D405/14 ,  C07D487/04 ,  A61K31/55 ,  A61P25/28

CPC分类号： C07D213/75 ,  C07D211/70 ,  C07D211/74 ,  C07D211/82 ,  C07D217/26 ,  C07D239/48 ,  C07D241/04 ,  C07D243/08 ,  C07D295/135 ,  C07D401/04 ,  C07D401/12 ,  C07D405/10 ,  C07D405/14 ,  C07D487/04

摘要： The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.