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公开(公告)号：EP1581488A1
公开(公告)日：2005-10-05
申请号：EP03813772.5
申请日：2003-12-19
发明人： BANDARAGE, Upul , COME, Jon, H. , PEROLA, Emanuele , BHISETTI, Govinda, Rao , SAUNDERS, Jeffrey, O. , WANG, Tiansheng
IPC分类号： C07D207/12 , C07D261/04 , C07D205/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07C323/65 , A61K31/40 , A61P35/00
CPC分类号： C07D401/12 , C07C323/65 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D261/04 , C07D403/12 , C07D413/12
摘要： The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
摘要翻译： 本发明涉及抑制TACE的化合物，其组合物以及使用这些化合物和组合物治疗疾病的方法。
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2.发明授权2-(4-AMINO-1,2,5-OXADIAZOL-4-YL)-IMIDAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS 有权2-（4-氨基-1,2,5-恶二唑-4-基） - 咪唑化合物作为蛋白激酶抑制剂的
公开(公告)号：EP1660467B1
公开(公告)日：2011-12-07
申请号：EP04781796.0
申请日：2004-08-20
发明人： COME, Jon, H. , GREEN, Jeremy , MARHEFKA, Craig , HARBESON, Scott, L. , PHAM, Ly
IPC分类号： C07D417/14 , C07D417/04 , C07D413/14 , C07D413/04 , C07D271/10 , A61K31/4245 , A61P11/06 , A61P3/10 , A61P25/28 , A61P25/18 , A61P25/16 , A61P35/00 , A61P9/00 , A61P31/12 , A61P17/14
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. In certain embodiments, these compounds are effective as inhibitors of p70S6k, GSK- 3 and/or ROCK protein kinases. These compounds have the general formula I.
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公开(公告)号：EP1581488B1
公开(公告)日：2009-09-16
申请号：EP03813772.5
申请日：2003-12-19
发明人： BANDARAGE, Upul , COME, Jon, H. , PEROLA, Emanuele , BHISETTI, Govinda, Rao , SAUNDERS, Jeffrey, O. , WANG, Tiansheng
IPC分类号： C07D207/12 , C07D261/04 , C07D205/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07C323/65 , A61K31/40 , A61P35/00
CPC分类号： C07D401/12 , C07C323/65 , C07C2601/08 , C07D205/04 , C07D207/12 , C07D261/04 , C07D403/12 , C07D413/12
摘要： The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.
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公开(公告)号：EP2283013A1
公开(公告)日：2011-02-16
申请号：EP09733572.3
申请日：2009-04-14
发明人： WANG, Tiansheng , ARONOV, Alexander , CORNEBISE, Mark , MALTAIS, Francois , LEDOBOER, Mark , LE TIRAN, Arnaud , MARONE, Valerie , MESSERSMITH, David , COTTRELL, Kevin , COME, Jon, H. , BOTELA, Gabriel, Martinez
IPC分类号： C07D417/04 , C07D513/04 , A61K31/428 , A61K31/4365 , A61P37/00
CPC分类号： C07D513/04 , C07D417/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K ggr;. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及用作PI3K抑制剂的化合物，特别是PI3K ggr。的抑制剂。 本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。
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5.发明公开
公开(公告)号：EP1660467A2
公开(公告)日：2006-05-31
申请号：EP04781796.0
申请日：2004-08-20
发明人： COME, Jon, H. , GREEN, Jeremy , MARHEFKA, Craig , HARBESON, Scott, L. , PHAM, Ly
IPC分类号： C07D271/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. In certain embodiments, these compounds are effective as inhibitors of p70S6k, GSK- 3 and/or ROCK protein kinases. These compounds have the general formula I.
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公开(公告)号：EP1389194A2
公开(公告)日：2004-02-18
申请号：EP02725881.3
申请日：2002-04-29
发明人： BHISETTI, Govinda, R. , SAUNDERS, Jeffrey, O. , MURCKO, Mark, A. , LEPRE, Christopher, A. , BRITT, Shawn, D. , COME, Jon, H. , DENINGER, David, D. , WANG, Tianshang
IPC分类号： C07D295/12 , C07D215/48 , C07D241/04 , C07D239/48 , C07D211/74 , C07D211/82 , C07D401/12 , C07D405/14 , C07D487/04 , A61K31/55 , A61P25/28
CPC分类号： C07D213/75 , C07D211/70 , C07D211/74 , C07D211/82 , C07D217/26 , C07D239/48 , C07D241/04 , C07D243/08 , C07D295/135 , C07D401/04 , C07D401/12 , C07D405/10 , C07D405/14 , C07D487/04
摘要： The present invention relates to inhibitors of aspartic proteinases, particularly, BACE. The present invention also relates to compositions thereof and methods therewith for inhibiting BACE activity in a mammal, and for treating Alzheimer's Disease and other BACE-mediated diseases.
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公开(公告)号：EP2516417B1
公开(公告)日：2017-10-11
申请号：EP10805555.9
申请日：2010-12-21
发明人： ARONOV, Alex , COME, Jon, H. , DAVIES, Robert, J. , PIERCE, Albert, C. , WANG, Jian , NANTHAKUMAR, Suganthini , CAO, Jingrong , BANDARAGE, Upul, K. , KRUEGER, Elaine , TIRAN, Amaud, Le , LIAO, Yusheng , MESSERSMITH, David , COLLIER, Philip, N. , GREY, Ronald , O'DOWD, Hardwin , HENDERSON, James, A. , GRILLOT, Anne-Laure
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , A61K31/352 , A61K31/424 , A61K31/429 , A61P9/00 , A61P29/00 , A61P37/00
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
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8.发明公开ISOINDOLINONE INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASE 有权ISOINDOLINONHEMMER DER PHOSPHATIDYLINOSITOL 3-KINASE
公开(公告)号：EP2516417A1
公开(公告)日：2012-10-31
申请号：EP10805555.9
申请日：2010-12-21
发明人： ARONOV, Alex , COME, Jon, H. , DAVIES, Robert, J. , PIERCE, Albert, C. , WANG, Jian , NANTHAKUMAR, Suganthini , CAO, Jingrong , BANDARAGE, Upul, K. , KRUEGER, Elaine , TIRAN, Amaud, Le , LIAO, Yusheng , MESSERSMITH, David , COLLIER, Philip, N. , GREY, Ronald , O'DOWD, Hardwin , HENDERSON, James, A. , GRILLOT, Anne-Laure
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , A61K31/352 , A61K31/424 , A61K31/429 , A61P9/00 , A61P29/00 , A61P37/00
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：EP2440556A1
公开(公告)日：2012-04-18
申请号：EP10730287.9
申请日：2010-06-08
发明人： COTTRELL, Kevin, Michael , ARONOV, Alex , DAVIES, Robert, J. , COME, Jon, H. , MESSERSMITH, David , XU, Jingwang , BANDARAGE, Upul, K. , CAO, Jingrong
IPC分类号： C07D417/06 , A61K31/427 , A61P25/00
CPC分类号： C07D417/06
摘要： The present invention relates to compounds useful as inhibitors of PBK, particularly of PBKγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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