公开(公告)号：EP3426687A1

公开(公告)日：2019-01-16

申请号：EP17708811.9

申请日：2017-03-06

申请人： VIB vzw ,  Universiteit Gent ,  Vrije Universiteit Brussel

发明人： TAVERNIER, Jan ,  VAN DER HEYDEN, José ,  DEVOOGDT, Nick ,  D'HUYVETTER, Matthias ,  KRASNIQI, Ahmet

IPC分类号： C07K16/28 ,  A61K51/10 ,  G01N33/574 ,  A61P35/00

公开(公告)号：EP3174559A1

公开(公告)日：2017-06-07

申请号：EP15744895.2

申请日：2015-07-17

申请人： Vrije Universiteit Brussel

发明人： LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  D'HUYVETTER, Matthias ,  DE VOS, Jens

IPC分类号： A61K51/10 ,  A61P35/00

CPC分类号： A61K51/1045 ,  A61K9/0019 ,  A61K51/1051 ,  A61K51/1069 ,  A61K51/1072 ,  A61K51/1078 ,  A61K51/1096 ,  C07K16/32 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (V
HH ) or functional fragments thereof, wherein said V
HH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions,for use in methods for the prevention and/or treatment of cancer.

摘要翻译： 本申请提供了多肽，其包含或基本上由重链抗体（VHH）或其功能性片段的至少一个重链可变结构域的其worin所述V HH或其功能性片段特异性地结合到靶蛋白确实是存在于和/或特定的 用于固体肿瘤或癌症细胞，例如，HER2。 本申请还提供编码检查的多肽的核酸; 用于制备寻求多肽的方法; 宿主细胞中表达或能够表达寻求的多肽; 组合物，并且具体地涉及药物组合物确实包括搜索多肽，核酸和/或宿主细胞。 本申请还提供搜索多肽，核酸，宿主细胞和/或组合物，用于预防和/或治疗癌症的方法中使用。

公开(公告)号：EP3718574A1

公开(公告)日：2020-10-07

申请号：EP20166462.0

申请日：2015-07-17

申请人： Vrije Universiteit Brussel

发明人： LAHOUTTE, Tony ,  DEVOOGDT, Nick ,  D'HUYVETTER, Matthias ,  DE VOS, Jens

IPC分类号： A61K51/10 ,  A61P35/00

摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (V HH ) or functional fragments thereof, wherein said V HH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions, for use in methods for the prevention and/or treatment of cancer.

公开(公告)号：EP4149543A1

公开(公告)日：2023-03-22

申请号：EP21724177.7

申请日：2021-05-17

申请人： Université de Liège ,  Centre Hospitalier Universitaire de Liège ,  Vrije Universiteit Brussel ,  KTH Holding Aktiebolag

发明人： CAERS, Jo ,  DURAY, Elodie ,  DUMOULIN, Mireille ,  D'HUYVETTER, Matthias ,  ERIKSSON KARLSTRÖM, Amelie

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/28

公开(公告)号：EP3325020A1

公开(公告)日：2018-05-30

申请号：EP16745643.3

申请日：2016-07-15

申请人： Vrije Universiteit Brussel

发明人： LAHOUTTE, Tony ,  D'HUYVETTER, Matthias ,  DE VOS, Jens ,  DEVOOGDT, Nick

IPC分类号： A61K51/10 ,  C07K16/32 ,  A61K101/02 ,  A61K103/30 ,  A61P35/00

CPC分类号： A61K51/1096 ,  A61K51/1051 ,  A61K51/1093 ,  A61K2039/505 ,  A61K2039/54 ,  A61P35/00 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569

摘要： Provided herein are methods, kits, and compositions for stratifying and treating subjects, e.g., subjects having cancer. In some examples, the methods involve use of a radiolabelled heavy chain variable domain derived from a heavy chain antibody (VHH), or a functional fragment thereof, as both a screening agent and a treatment agent. In some examples, the VHH, or a functional fragment thereof, that is radiolabelled with a radioisotope that is both a γ-emitter and β-emitter.