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公开(公告)号：EP4267620A1
公开(公告)日：2023-11-01
申请号：EP21843908.1
申请日：2021-12-20
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2.发明公开RADIO-LABELLED ANTIBODY FRAGMENTS FOR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER 审中-公开放射标记抗体片段用途在预防和/或治疗癌症
公开(公告)号：EP3174559A1
公开(公告)日：2017-06-07
申请号：EP15744895.2
申请日：2015-07-17
CPC分类号： A61K51/1045 , A61K9/0019 , A61K51/1051 , A61K51/1069 , A61K51/1072 , A61K51/1078 , A61K51/1096 , C07K16/32 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (V
HH ) or functional fragments thereof, wherein said V
HH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions,for use in methods for the prevention and/or treatment of cancer.摘要翻译： 本申请提供了多肽，其包含或基本上由重链抗体（VHH）或其功能性片段的至少一个重链可变结构域的其worin所述V HH或其功能性片段特异性地结合到靶蛋白确实是存在于和/或特定的 用于固体肿瘤或癌症细胞，例如，HER2。 本申请还提供编码检查的多肽的核酸; 用于制备寻求多肽的方法; 宿主细胞中表达或能够表达寻求的多肽; 组合物，并且具体地涉及药物组合物确实包括搜索多肽，核酸和/或宿主细胞。 本申请还提供搜索多肽，核酸，宿主细胞和/或组合物，用于预防和/或治疗癌症的方法中使用。
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公开(公告)号：EP3758742A1
公开(公告)日：2021-01-06
申请号：EP19707807.4
申请日：2019-03-01
发明人： VAN GINDERACHTER, Jo , RAES, Geert , DEVOOGDT, Nick , KEYAERTS, Marleen , LECOCQ, Quentin , XAVIER, Catarina , BRECKPOT, Karine , BROOS, Katrijn , BRIDOUX, Jessica
IPC分类号： A61K39/00 , A61K39/395 , C07K16/28 , A61P35/00
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公开(公告)号：EP3426687A1
公开(公告)日：2019-01-16
申请号：EP17708811.9
申请日：2017-03-06
发明人： TAVERNIER, Jan , VAN DER HEYDEN, José , DEVOOGDT, Nick , D'HUYVETTER, Matthias , KRASNIQI, Ahmet
IPC分类号： C07K16/28 , A61K51/10 , G01N33/574 , A61P35/00
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5.发明授权
公开(公告)号：EP2968487B1
公开(公告)日：2019-01-30
申请号：EP14710327.9
申请日：2014-03-17
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6.发明公开ANTI-MACROPHAGE MANNOSE RECEPTOR SINGLE VARIABLE DOMAINS FOR TARGETING AND IN VIVO IMAGING OF TUMOR-ASSOCIATED MACROPHAGES 审中-公开单变量ANTI巨噬细胞甘露糖受体的网域瞄准和在肿瘤相关巨噬细胞体内成像
公开(公告)号：EP2855526A1
公开(公告)日：2015-04-08
申请号：EP13713373.2
申请日：2013-03-15
发明人： VAN GINDERACHTER, Jo , DE BAETSELIER, Patrick , DEVOOGDT, Nick , LAHOUTTE, Tony , LAOUI, Damya , MOVAHEDI, Kiavash , RAES, Geert , SCHOONOOGHE, Steve
IPC分类号： C07K16/28
CPC分类号： A61K51/1027 , A61K2039/505 , C07K16/2851 , C07K2317/22 , C07K2317/33 , C07K2317/569 , C07K2317/92
摘要： The present invention relates to immunoglobulin single variable domains directed against human macrophage mannose receptor (MMR) and their uses in the field of oncology. More specifically, it concerns immunoglobulin single variable domains, including nanobodies, against human MMR and their use in targeting and in vivo imaging of tumor-associated macrophages, with applications in the field of cancer diagnostics and therapeutics and monitoring of the disease.
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7.发明公开THE USE OF A POLYPEPTIDE DOMAIN OF SLPI TO MODULATE THE TUMORIGENIC AND METASTATIC POTENTIAL OF CANCER CELLS 审中-公开使用肿瘤和转移POTENTIEL癌细胞的调制的多肽SLPI
公开(公告)号：EP1620121A2
公开(公告)日：2006-02-01
申请号：EP04729903.7
申请日：2004-04-28
IPC分类号： A61K38/08 , A61K39/395 , A61P35/00
CPC分类号： A61K38/57
摘要： The present invention relates to the use of a polypeptide domain to modulate the tumorigenic and metastatic potential of cancer cells. More specifically, the present invention relates to a domain of a Secretory Leukocyte Protease Inhibitor (SLPI) to modulate tumor invasiveness and/or metastasis. It further relates to compounds, such as antibodies, that interact with said domain and repress the tumor invasiveness and/or the metastasis.
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8.发明公开
公开(公告)号：EP3718574A1
公开(公告)日：2020-10-07
申请号：EP20166462.0
申请日：2015-07-17
摘要： The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (V HH ) or functional fragments thereof, wherein said V HH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g. HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions, for use in methods for the prevention and/or treatment of cancer.
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公开(公告)号：EP2748196B8
公开(公告)日：2016-11-30
申请号：EP12751318.2
申请日：2012-08-22
申请人： Université Grenoble Alpes , Centre Hospitalier Universitaire de Grenoble , Vrije Universiteit Brussel
发明人： GHEZZI, Catherine , FAGRET, Daniel , BROISAT, Alexis , DEVOOGDT, Nick , LAHOUTTE, Tony , MUYDERMANS, Serge
IPC分类号： C07K16/28 , A61K39/395 , A61P9/00
CPC分类号： C07K16/2803 , A61K51/1027 , C07K16/2836 , C07K2317/22 , C07K2317/33 , C07K2317/565 , C07K2317/569 , C07K2317/92 , C07K2317/94 , G01N33/6893
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公开(公告)号：EP3325020A1
公开(公告)日：2018-05-30
申请号：EP16745643.3
申请日：2016-07-15
IPC分类号： A61K51/10 , C07K16/32 , A61K101/02 , A61K103/30 , A61P35/00
CPC分类号： A61K51/1096 , A61K51/1051 , A61K51/1093 , A61K2039/505 , A61K2039/54 , A61P35/00 , C07K16/30 , C07K16/32 , C07K2317/22 , C07K2317/565 , C07K2317/569
摘要： Provided herein are methods, kits, and compositions for stratifying and treating subjects, e.g., subjects having cancer. In some examples, the methods involve use of a radiolabelled heavy chain variable domain derived from a heavy chain antibody (VHH), or a functional fragment thereof, as both a screening agent and a treatment agent. In some examples, the VHH, or a functional fragment thereof, that is radiolabelled with a radioisotope that is both a γ-emitter and β-emitter.
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