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    CO-LYOPHILIZED COMPLEX COMPRISING A NUCLEIC ACID VECTOR AND A FORMULATING AGENT
    1.
    发明授权
    CO-LYOPHILIZED COMPLEX COMPRISING A NUCLEIC ACID VECTOR AND A FORMULATING AGENT 有权
    包含核酸载体和制剂的共冻干复合物

    公开(公告)号：EP1104309B1

    公开(公告)日：2006-05-03

    申请号：EP99939113.9

    申请日：1999-08-10

    申请人： Valentis Inc.

    发明人： BRUNO, Maria ,  TAGLIAFERRI, Jenna ,  LAWSON, Luke ,  LOGAN, Mark, J. ,  MUMPER, Russ

    IPC分类号： A61K48/00 ,  C12N15/87

    CPC分类号： A61K48/00 ,  C12N15/87 ,  Y10S977/792 ,  Y10S977/80 ,  Y10S977/801 ,  Y10S977/906 ,  Y10S977/907

    摘要： The present invention, as noted above, relates generally to the incorporation of plasmid into a conventional dosage form, and more particularly to the production of a single-vial, homogenized, plasmid/polymer complex with desirable physical characteristics. Methods of making, storing and using such a complex are also provided and described in detail below. Such products and methods will provide more convenient and cost-effective complexes, which will be protected against chemical degradation and/or physical aggregation of its components and will provide for relative ease of administration. Thus, the present invention provides a more efficient complex for plasmid delivery and a method of incorporation of that plasmid into a conventional dosage form.

    摘要翻译： 如上所述，本发明一般涉及将质粒掺入常规剂型，更具体地涉及生产具有所需物理特性的单瓶均质的质粒/聚合物复合物。 下面还提供并且详细描述制造，储存和使用这种复合物的方法。 这样的产品和方法将提供更方便和成本有效的复合物，其将被保护免受化学降解和/或其组分的物理聚集，并且将提供相对容易的施用。 因此，本发明提供了用于质粒递送的更有效的复合物和将该质粒并入常规剂型的方法。