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    GENE EXPRESSION PROFILING IN PRIMARY OVARIAN SEROUS PAPILLARY TUMORS AND NORMAL OVARIAN EPITHELIUM
    3.
    发明公开
    GENE EXPRESSION PROFILING IN PRIMARY OVARIAN SEROUS PAPILLARY TUMORS AND NORMAL OVARIAN EPITHELIUM 有权
    在创建卵巢和师范OVARIALEPITHEL初级浆液性乳头状瘤基因表达谱

    公开(公告)号：EP1633854A4

    公开(公告)日：2007-07-25

    申请号：EP04776380

    申请日：2004-06-09

    申请人： UNIV ARKANSAS

    发明人： SANTIN ALESSANDRO

    IPC分类号： C12Q1/68 ,  C12N20060101 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

    CPC分类号： G01N33/689 ,  C12Q1/6886 ,  C12Q2600/106 ,  Y10S977/792

    摘要： Gene expression profiling and hierarchial clustering analysis readily distinguish normal ovarian epithelial cells from primary ovarian serous papillary carcinomas. Laminin, tumor-associated calcium signal transducer 1 and 2 (TROP­1/Ep-CAM; TROP-2), claudin 3, claudin 4, ladinin 1, S100A2, SERPIN2 (PAI-2), CD24, lipocalin 2, osteopontin, kallikrein 6 (protease M), kallikrein 10, matriptase and stratifin were found among the most highly overexpressed genes in ovarian serous papillary carcinomas, whereas transforming growth factor beta receptor III, platelet-derived growth factor receptor alpha, SEMACAP3, ras homolog gene family, member I (ARHI), thrombospondin 2 and disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2) were significantly down-regulated. Therapeutic strategy targeting TROP-1/Ep-CAM by monoclonal chimeric/humanized antibodies may be beneficial in patients harboring chemotherapy-resistant ovarian serous papillary carcinomas.

    GENE EXPRESSION PROFILING IN PRIMARY OVARIAN SEROUS PAPILLARY TUMORS AND NORMAL OVARIAN EPITHELIUM
    4.
    发明公开
    GENE EXPRESSION PROFILING IN PRIMARY OVARIAN SEROUS PAPILLARY TUMORS AND NORMAL OVARIAN EPITHELIUM 有权
    在创建卵巢和师范OVARIALEPITHEL初级浆液性乳头状瘤基因表达谱

    公开(公告)号：EP1633854A2

    公开(公告)日：2006-03-15

    申请号：EP04776380.0

    申请日：2004-06-09

    申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

    发明人： SANTIN, Alessandro

    IPC分类号： C12N1/00

    CPC分类号： G01N33/689 ,  C12Q1/6886 ,  C12Q2600/106 ,  Y10S977/792

    摘要： Gene expression profiling and hierarchial clustering analysis readily distinguish normal ovarian epithelial cells from primary ovarian serous papillary carcinomas. Laminin, tumor-associated calcium signal transducer 1 and 2 (TROP­1/Ep-CAM; TROP-2), claudin 3, claudin 4, ladinin 1, S100A2, SERPIN2 (PAI-2), CD24, lipocalin 2, osteopontin, kallikrein 6 (protease M), kallikrein 10, matriptase and stratifin were found among the most highly overexpressed genes in ovarian serous papillary carcinomas, whereas transforming growth factor beta receptor III, platelet-derived growth factor receptor alpha, SEMACAP3, ras homolog gene family, member I (ARHI), thrombospondin 2 and disabled-2/differentially expressed in ovarian carcinoma 2 (Dab2/DOC2) were significantly down-regulated. Therapeutic strategy targeting TROP-1/Ep-CAM by monoclonal chimeric/humanized antibodies may be beneficial in patients harboring chemotherapy-resistant ovarian serous papillary carcinomas.

    NUCLEIC ACID ANALYSIS BY RANDOM MIXTURES OF NON-OVERLAPPING FRAGMENTS
    6.
    发明授权
    NUCLEIC ACID ANALYSIS BY RANDOM MIXTURES OF NON-OVERLAPPING FRAGMENTS 有权
    非重叠碎片随机混合物的核酸分析

    公开(公告)号：EP1907571B1

    公开(公告)日：2017-04-26

    申请号：EP06760745.7

    申请日：2006-06-13

    申请人： Complete Genomics Inc.

    发明人： DRMANAC, Radoje

    IPC分类号： C12Q1/68 ,  C07H21/02

    CPC分类号： C12Q1/6874 ,  C07H21/04 ,  C07K1/047 ,  C12Q1/6806 ,  C12Q1/682 ,  C12Q1/6837 ,  C12Q1/6869 ,  C12Q2525/151 ,  C12Q2525/313 ,  C12Q2531/125 ,  C12Q2565/513 ,  G01N15/1404 ,  G01N15/1434 ,  Y10S977/778 ,  Y10S977/789 ,  Y10S977/792 ,  Y10S977/88 ,  Y10S977/882 ,  C12Q2521/307 ,  C12Q2525/161 ,  C12Q2535/122 ,  C12Q2563/179 ,  C12Q2565/514

    摘要： The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such final tier is from a particular aliquot, which, in turn, is from a particular aliquot of a prior tier, and so on. For every fragment of an aliquot in the final tier, the aliquots from which it was derived at every prior tier is known, or can be discerned. Thus, identical sequences from overlapping fragments from different aliquots can be distinguished and grouped as being derived from the same or different fragments from prior tiers. When the fragments in the final tier are sequenced, overlapping sequence regions of fragments in different aliquots are used to register the fragments so that non-overlapping regions are ordered. In one aspect, this process is carried out in a hierarchical fashion until the one or more target polynucleotides are characterized, e.g. by their nucleic acid sequences, or by an ordering of sequence segments, or by an ordering of single nucleotide polymorphisms (SNPs), or the like.

    摘要翻译： 本发明提供了用于对从一个或多个靶多核苷酸衍生的序列信息进行排序的方法和试剂盒。 在一个方面中，生成一个或多个分层和等分的层或等级，之后从最终等级或等级中的片段获得序列信息。 最后一层中的每个片段都来自一个特定的等分部分，而这个等分部分又来自前一层的特定等分部分，依此类推。 对于最后一层中的等分部分的每一个片段，其在之前的每一层中从其得到的等分部分是已知的，或可以被辨别。 因此，来自不同等分部分的重叠片段的相同序列可以被区分并分组为源自与之前等级相同或不同的片段。 当对最后一层中的片段进行测序时，使用不同等分部分的片段的重叠序列区域来记录片段，使得非重叠区域被排序。 在一个方面，该过程以分层方式进行，直到一个或多个靶多核苷酸被表征，例如， 通过它们的核酸序列，或通过序列区段的排序，或通过单核苷酸多态性（SNP）的排序等等。

    Nucleic acid analysis by random mixtures of non-overlapping fragments
    7.
    发明公开
    Nucleic acid analysis by random mixtures of non-overlapping fragments 有权
    NukleinsäureanalysedurchzufälligeMischungen von sichüberlappendenFragmenten

    公开(公告)号：EP2463386A3

    公开(公告)日：2012-08-15

    申请号：EP12150825.3

    申请日：2006-06-13

    申请人： Callida Genomics, Inc.

    发明人： Drmanac, Radoje

    IPC分类号： C12Q1/68 ,  G01N33/68

    CPC分类号： C12Q1/6874 ,  C07H21/04 ,  C07K1/047 ,  C12Q1/6806 ,  C12Q1/682 ,  C12Q1/6837 ,  C12Q1/6869 ,  C12Q2525/151 ,  C12Q2525/313 ,  C12Q2531/125 ,  C12Q2565/513 ,  G01N15/1404 ,  G01N15/1434 ,  Y10S977/778 ,  Y10S977/789 ,  Y10S977/792 ,  Y10S977/88 ,  Y10S977/882 ,  C12Q2521/307 ,  C12Q2525/161 ,  C12Q2535/122 ,  C12Q2563/179 ,  C12Q2565/514

    摘要： The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such final tier is from a particular aliquot, which, in turn, is from a particular aliquot of a prior tier, and so on. For every fragment of an aliquot in the final tier, the aliquots from which it was derived at every prior tier is known, or can be discerned. Thus, identical sequences from overlapping fragments from different aliquots can be distinguished and grouped as being derived from the same or different fragments from prior tiers. When the fragments in the final tier are sequenced, overlapping sequence regions of fragments in different aliquots are used to register the fragments so that non-overlapping regions are ordered. In one aspect, this process is carried out in a hierarchical fashion until the one or more target polynucleotides are characterized, e.g. by their nucleic acid sequences, or by an ordering of sequence segments, or by an ordering of single nucleotide polymorphisms (SNPs), or the like.

    摘要翻译： 本发明提供了用于排序从一个或多个目标多核苷酸衍生的序列信息的方法和试剂盒。 在一个方面，产生一个或多个分层或等级的碎片和等分，之后从最终级别或层级的片段获得序列信息。 这样的最后一层中的每个片段都来自特定的等分试样，而这些等分试样又是来自先前层的特定等分试样，等等。 对于最后一层中的等分试样的每个片段，从每个先前层得到的等分试样是已知的，或者可以被辨别出来。 因此，来自不同等分试样的重叠片段的相同序列可以被区分并分组为从与先前层相同或不同的片段衍生的。 当最终层中的片段被排序时，使用不同等分试样的片段的重叠序列区域来对片段进行寄存以使非重叠区域被排序。 在一个方面，该方法以分级方式进行，直到一个或多个目标多核苷酸被表征为例如。 通过其核酸序列，或通过序列片段的排序，或通过单核苷酸多态性（SNP）等的排序。

    FUNCTIONALIZED FLUORESCENT NANOCRYSTALS, AND METHODS FOR THEIR PREPARATION AND USE
    8.
    发明授权
    FUNCTIONALIZED FLUORESCENT NANOCRYSTALS, AND METHODS FOR THEIR PREPARATION AND USE 有权
    对于使用功能化的荧光纳米晶和方法以及

    公开(公告)号：EP1809720B1

    公开(公告)日：2012-05-02

    申请号：EP05858281.8

    申请日：2005-10-28

    申请人： Life Technologies Corporation

    发明人： NAASANI, Imad

    IPC分类号： C09K11/54 ,  G01N33/58

    CPC分类号： B82Y15/00 ,  C09K11/025 ,  C09K11/883 ,  G01N33/588 ,  Y10S977/773 ,  Y10S977/792 ,  Y10S977/793 ,  Y10S977/795 ,  Y10S977/811 ,  Y10S977/827 ,  Y10S977/83 ,  Y10T428/2991 ,  Y10T428/2993

    摘要： Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in the coating may form a capping layer on the fluorescent nanocrystal with the coating compounds operably bonded to the capping layer.