公开(公告)号：EP4015514A1

公开(公告)日：2022-06-22

申请号：EP21203535.6

申请日：2016-02-02

申请人： Valo Health, Inc.

发明人： ZHENG, Xiaozhang ,  NG, Pui Yee ,  HAN, Bingsong ,  THOMASON, Jennifer R. ,  ZABLOCKI, Mary-Margaret ,  LIU, Cuixian ,  DAVIS, Heather ,  RUDNITSKAYA, Aleksandra ,  LANCIA, David, Jr. ,  MILLAN, David S. ,  MARTIN, Matthew W.

IPC分类号： C07D403/06 ,  C07D413/06 ,  C07D243/14 ,  C07D267/12 ,  A61K31/551 ,  A61K31/553 ,  A61P35/00

摘要： The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I:

where R, L, X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , Y 3 , and Y 4 are described herein.

公开(公告)号：EP3932914A1

公开(公告)日：2022-01-05

申请号：EP21169630.7

申请日：2016-03-11

申请人： Valo Health, Inc.

发明人： BAIR, Kenneth W. ,  BARCZAK, Nicholas ,  HAN, Bingsong ,  LANCIA, David R., Jr. ,  LIU, Cuixian ,  MARTIN, Matthew W. ,  NG, Pui Yee ,  RUDNITSKAYA, Aleksandra ,  THOMASON, Jennifer R. ,  ZABLOCKI, Mary-Margaret ,  ZHENG, Xiaozhang

IPC分类号： C07D401/14 ,  C07D213/75 ,  C07C259/06 ,  A61P35/00 ,  C07D213/81 ,  C07D215/12 ,  C07C275/30 ,  C07D317/68 ,  C07D231/14 ,  C07D231/18 ,  C07D233/36 ,  C07D233/38 ,  C07D333/70 ,  C07D233/68 ,  C07D401/04

摘要： The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.