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公开(公告)号：EP3328401A1
公开(公告)日：2018-06-06
申请号：EP16832394.7
申请日：2016-07-29
发明人： MENDEL, Itzhak , PROPHETA-MEIRAN, Oshrat , SALEM, Yaniv , SHOHAM, Anat , YACOV, Niva , BREITBART, Eyal
IPC分类号： A61K35/13 , A61P35/00 , G01N33/574
CPC分类号： G01N33/574 , A61K38/00 , A61K45/06 , C07K14/00 , C07K16/18 , C07K16/30 , C07K2317/21 , C07K2317/54 , C07K2317/76 , G01N33/5017 , G01N33/5029 , G01N33/689
摘要： Disclosed herein are methods of treating, reducing the incidence of, or preventing one or more activities in or of a cancer cell, methods of treating, reducing the incidence of, or preventing migration or metastasis of a cancer cell, methods of treating, reducing the incidence of, or preventing a cancer by reducing tumor associated macrophages (TAMs) or their migration, and methods of treating, reducing the incidence of, or preventing a cancer (including metastatic cancer), for example, with an inhibitor of Motile Sperm Domain containing Protein 2 (MOSPD2). Also disclosed are inhibitors of MOSPD2 (e.g., anti-MOSPD2 antibodies or antigen binding fragments thereof) and pharmaceutical compositions containing MOSPD2 inhibitors. Also disclosed are methods for the prediction, diagnosis, or prognosis of cancer, cancer metastasis, tumor progression, or tumor invasiveness in a subject.
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公开(公告)号：EP3735981A1
公开(公告)日：2020-11-11
申请号：EP20173650.1
申请日：2016-07-29
IPC分类号： A61K38/00 , C12N9/20 , C07F9/09 , C07C59/125 , A61K39/00
摘要： The present invention relates to an inhibitor of Motile Sperm Domain containing Protein 2 (MOSPD2) for use in treating or preventing an inflammatory disease or disorder, wherein the inhibitor is a polypeptide, DNA or RNA.
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公开(公告)号：EP3223806B1
公开(公告)日：2020-01-15
申请号：EP15862487.4
申请日：2015-11-26
IPC分类号： A61K31/075 , C07F9/58 , A61K31/24
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公开(公告)号：EP3765490A1
公开(公告)日：2021-01-20
申请号：EP19767205.8
申请日：2019-03-13
发明人： MENDEL, Itzhak , SALEM, Yaniv , BREITBART, Eyal
IPC分类号： C07K14/705 , C07K14/725 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/46 , A61K35/13 , A61K38/16 , A61K38/17 , A61K39/395
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公开(公告)号：EP3328408A2
公开(公告)日：2018-06-06
申请号：EP16832393.9
申请日：2016-07-29
IPC分类号： A61K38/00 , C12N9/20 , C07F9/09 , C07C59/125
摘要： Disclosed herein are methods of treating, preventing, or reducing the incidence of an inflammatory disease or disorder and methods of inhibiting, preventing, or reducing the incidence of one or more activities in a cell with an inhibitor of a Motile Sperm Domain containing Protein 2 (MOSPD2). Also disclosed are inhibitors of MOSPD2 and pharmaceutical compositions containing MOSPD2 inhibitors.
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公开(公告)号：EP3223806A1
公开(公告)日：2017-10-04
申请号：EP15862487.4
申请日：2015-11-26
IPC分类号： A61K31/075 , C07C43/13 , C07F9/02 , A61K31/24
摘要： The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.
摘要翻译： 本发明涉及氧化脂质和包含其的药物组合物。 本发明还涉及制备本发明的氧化脂质的方法以及治疗或预防包含本发明氧化脂质的纤维化或炎性疾病或病症的方法。
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公开(公告)号：EP2791101A1
公开(公告)日：2014-10-22
申请号：EP12856859.9
申请日：2012-12-11
发明人： MENDEL, Itzhak , FEIGE, Erez , YACOV, Niva , PROPHETA-MEIRAN, Oshrat , BREITBART, Eyal , SALEM, Yaniv
IPC分类号： C07C53/00
CPC分类号： A61K31/661 , A61K31/366 , A61K31/404 , A61K31/436 , A61K31/585 , A61K31/685 , A61K45/06 , Y02A50/414 , A61K2300/00
摘要： Disclosed herein are methods of treating an inflammatory disease or disorder, as well as pharmaceutical compositions and kits useful for treating an inflammatory disease or disorder. The methods, compositions and kits utilize at least one agent, the at least one agent being capable of exhibiting at least two activities selected from the group consisting of: a) inhibiting CD 14 activity and/or a signaling pathway associated with CD 14 activity; b) inhibiting TLR2 activity and/or a signaling pathway associated with TLR2 activity; and c) inhibiting monocyte chemotaxis.
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公开(公告)号：EP3735977A1
公开(公告)日：2020-11-11
申请号：EP20173680.8
申请日：2016-07-29
发明人： MENDEL, Itzhak , PROPHETA-MEIRAN, Oshrat , SALEM, Yaniv , SHOHAM, Anat , YACOV, Niva , BREITBART, Eyal
IPC分类号： A61K35/13 , A61P35/00 , G01N33/574
摘要： An inhibitor of Motile Sperm Domain containing Protein 2 (MOSPD2) for use in treating or preventing cancer, wherein the inhibitor is a polypeptide, DNA or RNA.
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公开(公告)号：EP3328408B1
公开(公告)日：2020-10-07
申请号：EP16832393.9
申请日：2016-07-29
IPC分类号： A61K38/00 , C12N9/20 , C07F9/09 , C07C59/125 , A61K39/00
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公开(公告)号：EP3223824A1
公开(公告)日：2017-10-04
申请号：EP15863247.1
申请日：2015-11-26
发明人： MENDEL, Itzhak , SALEM, Yaniv , YACOV, Niva , BREITBART, Eyal
IPC分类号： A61K31/661
CPC分类号： A61K31/685 , A61K9/0053 , C07F9/106
摘要： The present invention is directed to methods of treating or preventing fibrosis comprising an oxidized lipid or pharmaceutical composition comprising the same.
摘要翻译： 本发明涉及治疗或预防纤维化的方法，其包含氧化的脂质或包含其的药物组合物。
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