专利检索 ap:("Vernalis PLC" OR "Beth Israel Deaconess Medical Center, Inc.") AND inv:"MCKEE, Timothy, D." 第 1 页

1.

发明公开
DETERMINATION OF A PHOSPHORYLATION SITE IN PPIASE DOMAIN OF PIN1 AND USES THEREFOR 审中-公开
标题翻译：一个PHOSPHORYLIERUNGSORTS在PPI酶的测定周围，其用途PIN1

公开(公告)号：EP1771556A2

公开(公告)日：2007-04-11

申请号：EP05807006.1

申请日：2005-07-15

申请人： Vernalis PLC , Beth Israel Deaconess Medical Center, Inc.

发明人： LU, Kun, Ping , SOWADSKI, Janusz, M. , SUTO, Robert, K. , MCKEE, Timothy, D. , KIMZEY, Amy, L. , SUIZU, Futoshi

IPC分类号： C12N9/90 , C30B29/58 , C07K16/40 , C12Q1/533 , C12N15/11 , C12N15/61 , C12N1/21

CPC分类号： C12N9/90 , C07K2299/00 , Y02A90/24

摘要： This invention relates to methods of determining the prognosis of a subject with a Pin1 associated disorder by evaluating the levels of phosphorylated Pin1 in a biological sample. The invention also provides Pin1 polypeptides phosphorylated position 16, position 71, or both. The invention further relates to a crystal structure of a pPin1(71) polypeptide and a pPin1(16)(71) polypeptide. The invention also provides constitutively active mutants of Pin1 and modulators that are specific for the molecules. The invention further provides methods for determining if a subject is at risk of developing a Pin1 associated state by determining if a the subject has a mutation in Pin1 that renders the polypeptide constitutively active.