公开(公告)号：EP3250562A1

公开(公告)日：2017-12-06

申请号：EP16744240.9

申请日：2016-01-29

申请人： Biomed Valley Discoveries, Inc. ,  Vertex Pharmaceuticals Incorporated

发明人： DECRESCENZO, Gary ,  WELSCH, Dean ,  VLAHOVA, Petinka I. ,  BOERRIGTER, Stephan X.M. ,  ARONOV, Alexander ,  KESHAVARZ-SHOKRI, Ali ,  SCANGAS, Alexander N. ,  STAVROPOULOS, Kathy ,  LITTLER, Benjamin ,  KADIYALA, Irina Nikolaevna ,  ALARGOVA, Rossitza Gueorguieva

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

摘要： The present invention provides crystalline forms of a compound of formula (I): Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

公开(公告)号：EP2872122A1

公开(公告)日：2015-05-20

申请号：EP13742782.9

申请日：2013-07-15

申请人： Vertex Pharmaceuticals Incorporated

发明人： ALARGOVA, Rossitza Gueorguieva ,  DUNBAR, Craig Antony ,  KADIYALA, Irina Nikolaevna

IPC分类号： A61K9/20 ,  A61K31/404 ,  A61K31/47 ,  A61K45/06 ,  A61P43/00

CPC分类号： A61K31/47 ,  A61K9/1652 ,  A61K9/2054 ,  A61K31/36 ,  A61K31/404 ,  A61K45/06 ,  Y10S514/851 ,  A61K2300/00

摘要： A pharmaceutical composition comprising Compound 1, (R)-1-(2,2-difluorobenzo[d][1,3]dioxo-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide, and at least one excipient selected from: a filler, a disintegrant, a surfactant, a glidant and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Methods for treating a patient in need thereof include administering the pharmaceutical composition of Compound 1 are also disclosed.