公开(公告)号：EP3333184A1

公开(公告)日：2018-06-13

申请号：EP17198390.1

申请日：2017-10-25

申请人： Virogin Biotech Canada Ltd

发明人： Jia, William ,  Bu, Xuexian ,  Lee, I-Fang

IPC分类号： C07K14/705 ,  A61K38/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/06 ,  C07K14/70503 ,  C07K2319/30

摘要： Methods and compositions comprising fragments of the programmed death-1 protein (PD-1) ectodomain for inhibiting and/or interfering with interactions between PD-1 (also known as CD279) and programmed death-ligand 1 (PD-L1) and/or programmed death-ligand 2 (PD-L2) are disclosed. In addition, methods and compositions for increasing IL-2 levels in a cell, and methods and compositions for preventing, treating, or ameliorating the effects of cancer in a subject, are disclosed.

公开(公告)号：EP3333184B1

公开(公告)日：2019-10-09

申请号：EP17198390.1

申请日：2017-10-25

申请人： Virogin Biotech Canada Ltd

发明人： Jia, William ,  Bu, Xuexian ,  Lee, I-Fang

IPC分类号： C07K14/705 ,  A61K38/00