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公开(公告)号：EP3886860A1
公开(公告)日：2021-10-06
申请号：EP19889246.5
申请日：2019-11-29
发明人： JIA, William , CHOULJENKO, Dmitry, V. , LEE, I-Fang , MURAD, Yanal, M. , LIU, Xiaohu , LIU, Guoyu , BU, Xuexian , DELWAR, Zahid
IPC分类号： A61K31/519 , A61K31/7088 , A61K31/7105 , A61K31/76 , A61K35/761 , A61K35/763
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公开(公告)号：EP3490583A1
公开(公告)日：2019-06-05
申请号：EP17837576.2
申请日：2017-08-01
发明人： JIA, William , LIU, Guoyu , LEE, Erica , CHOULJENKO, Dmitry , DING, Jun
IPC分类号： A61K38/17 , A61K38/20 , C07K14/035 , C07K14/54 , C12N15/869
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公开(公告)号：EP3416680A1
公开(公告)日：2018-12-26
申请号：EP17754008.5
申请日：2017-02-18
发明人： JIA, William , DELWAR, Zahid
CPC分类号： A61K39/00 , A61K35/76 , A61K35/763 , A61K39/12
摘要： The present disclosure relates to the use of an oncolytic virus, such as HSV, and a STAT1/3 inhibitor, such as nifuroxazide and C16, in the treatment of cancer. Therapeutic compositions are provided that may be used to prevent, treat, or ameliorate the effects of a targeted cancer. Methods of using such compositions are also disclosed, such as methods of using the therapeutic compositions for improving efficacy of an oncolytic virotherapy (and for preventing macrophage and microglia inhibition of oncolytic viral activity).
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公开(公告)号：EP4395799A1
公开(公告)日：2024-07-10
申请号：EP22865772.2
申请日：2022-08-31
发明人： FLOYD, Michael , GRZESIK, Peter , KENNEDY, Edward M. , FARKALY, Terry , LERNER, Lorena , FEAU, Sonia , STRATHDEE, Craig A. , QUÉVA, Christophe
IPC分类号： A61K35/763 , A61P35/00 , C12N7/00
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公开(公告)号：EP4122478A1
公开(公告)日：2023-01-25
申请号：EP22180454.5
申请日：2017-02-18
发明人： JIA, William , DELWAR, Zahid
IPC分类号： A61K35/76 , A61K39/00 , A61K39/12 , A61K35/763 , A61P35/00
摘要： The present disclosure relates to the use of an oncolytic virus, such as HSV, and a STAT1/3 inhibitor, such as nifuroxazide and C16, in the treatment of cancer. Therapeutic compositions are provided that may be used to prevent, treat, or ameliorate the effects of a targeted cancer. Methods of using such compositions are also disclosed, such as methods of using the therapeutic compositions for improving efficacy of an oncolytic virotherapy (and for preventing macrophage and microglia inhibition of oncolytic viral activity).
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公开(公告)号：EP4009996A1
公开(公告)日：2022-06-15
申请号：EP20849790.9
申请日：2020-08-05
IPC分类号： A61K35/76 , A61K35/768 , A61P35/00 , C12N15/11 , C12N15/113
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公开(公告)号：EP3743084A2
公开(公告)日：2020-12-02
申请号：EP19744583.6
申请日：2019-01-24
IPC分类号： A61K35/17 , A61K39/395 , C07K14/705 , C07K14/725 , C07K16/28 , C07K16/30 , C12N5/0783 , C12N5/09 , C12N5/10
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公开(公告)号：EP3448401A1
公开(公告)日：2019-03-06
申请号：EP17790621.1
申请日：2017-04-29
发明人： JIA, William , CHOULJENKO, Dmitry , BU, Xuexian , LIU, Guoyu
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公开(公告)号：EP3333184A1
公开(公告)日：2018-06-13
申请号：EP17198390.1
申请日：2017-10-25
发明人： Jia, William , Bu, Xuexian , Lee, I-Fang
IPC分类号： C07K14/705 , A61K38/00
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/70503 , C07K2319/30
摘要： Methods and compositions comprising fragments of the programmed death-1 protein (PD-1) ectodomain for inhibiting and/or interfering with interactions between PD-1 (also known as CD279) and programmed death-ligand 1 (PD-L1) and/or programmed death-ligand 2 (PD-L2) are disclosed. In addition, methods and compositions for increasing IL-2 levels in a cell, and methods and compositions for preventing, treating, or ameliorating the effects of cancer in a subject, are disclosed.
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10.发明公开
公开(公告)号：EP4313094A1
公开(公告)日：2024-02-07
申请号：EP22776677.1
申请日：2022-03-24
发明人： JIA, William, Wei-Guo , CHOULJENKO, Dmitry, V. , LEE, I-Fang , MURAD, Yanal, M. , LIU, Xiaohu , LIU, Guoyu , BU, Xuexian , DELWAR, Zahid , DING, Jun
IPC分类号： A61K35/763 , A61P35/00 , C12N15/113 , C12N15/86
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