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公开(公告)号：EP3886860A1
公开(公告)日：2021-10-06
申请号：EP19889246.5
申请日：2019-11-29
发明人： JIA, William , CHOULJENKO, Dmitry, V. , LEE, I-Fang , MURAD, Yanal, M. , LIU, Xiaohu , LIU, Guoyu , BU, Xuexian , DELWAR, Zahid
IPC分类号： A61K31/519 , A61K31/7088 , A61K31/7105 , A61K31/76 , A61K35/761 , A61K35/763
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公开(公告)号：EP4122478A1
公开(公告)日：2023-01-25
申请号：EP22180454.5
申请日：2017-02-18
发明人： JIA, William , DELWAR, Zahid
IPC分类号： A61K35/76 , A61K39/00 , A61K39/12 , A61K35/763 , A61P35/00
摘要： The present disclosure relates to the use of an oncolytic virus, such as HSV, and a STAT1/3 inhibitor, such as nifuroxazide and C16, in the treatment of cancer. Therapeutic compositions are provided that may be used to prevent, treat, or ameliorate the effects of a targeted cancer. Methods of using such compositions are also disclosed, such as methods of using the therapeutic compositions for improving efficacy of an oncolytic virotherapy (and for preventing macrophage and microglia inhibition of oncolytic viral activity).
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公开(公告)号：EP3448401A1
公开(公告)日：2019-03-06
申请号：EP17790621.1
申请日：2017-04-29
发明人： JIA, William , CHOULJENKO, Dmitry , BU, Xuexian , LIU, Guoyu
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公开(公告)号：EP3490583A1
公开(公告)日：2019-06-05
申请号：EP17837576.2
申请日：2017-08-01
发明人： JIA, William , LIU, Guoyu , LEE, Erica , CHOULJENKO, Dmitry , DING, Jun
IPC分类号： A61K38/17 , A61K38/20 , C07K14/035 , C07K14/54 , C12N15/869
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公开(公告)号：EP3416680A1
公开(公告)日：2018-12-26
申请号：EP17754008.5
申请日：2017-02-18
发明人： JIA, William , DELWAR, Zahid
CPC分类号： A61K39/00 , A61K35/76 , A61K35/763 , A61K39/12
摘要： The present disclosure relates to the use of an oncolytic virus, such as HSV, and a STAT1/3 inhibitor, such as nifuroxazide and C16, in the treatment of cancer. Therapeutic compositions are provided that may be used to prevent, treat, or ameliorate the effects of a targeted cancer. Methods of using such compositions are also disclosed, such as methods of using the therapeutic compositions for improving efficacy of an oncolytic virotherapy (and for preventing macrophage and microglia inhibition of oncolytic viral activity).
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公开(公告)号：EP3710018A1
公开(公告)日：2020-09-23
申请号：EP18878449.0
申请日：2018-11-16
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公开(公告)号：EP3660043A1
公开(公告)日：2020-06-03
申请号：EP19202085.7
申请日：2017-10-25
发明人： JIA, William , BU, Xuexian , LEE, I-Fang
IPC分类号： C07K14/705 , A61K38/00 , C07K7/08 , A61P35/00 , C07K7/06
摘要： Methods and compositions for inhibiting and/or interfering with interactions between (1) programmed Death-1 protein (also known as CD279) and (2) programmed death-ligand 1 (PD-L1) and/or programmed death-ligand 2 (PD-L2) are disclosed. In addition, methods and compositions for increasing IL-2 levels in a cell, and methods and compositions for preventing, treating, or ameliorating the effects of cancer in a subject, are disclosed.
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