公开(公告)号：EP2747860A4

公开(公告)日：2015-04-01

申请号：EP12826799

申请日：2012-08-23

申请人： WATERS TECHNOLOGIES CORP

发明人： MICHIENZI JOSEPH D

IPC分类号： B01D15/08 ,  F16L13/14 ,  G01N30/60

CPC分类号： B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

摘要： An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.

公开(公告)号：EP2999961A4

公开(公告)日：2016-12-28

申请号：EP14800388

申请日：2014-05-15

申请人： WATERS TECHNOLOGIES CORP

发明人： FOGWILL MICHAEL O ,  MICHIENZI JOSEPH D ,  MURPHY JAMES P

IPC分类号： G01N30/38 ,  B01D15/16 ,  B01D15/40 ,  G01N30/30 ,  G01N30/32 ,  G01N30/34 ,  G01N30/72 ,  G01N30/84

CPC分类号： G01N30/30 ,  B01D15/161 ,  B01D15/40 ,  G01N30/16 ,  G01N30/32 ,  G01N30/34 ,  G01N30/7213 ,  G01N30/84 ,  G01N2030/3038

摘要： A chromatography system includes a separation column that separates a sample carried by a compressible mobile phase flow into analytes and a splitter in fluidic communication with the separation column to receive and divide the compressible mobile phase flow into first and second mobile phase streams in accordance with a split ratio. A thermally modulated variable restrictor is coupled between the splitter and a detector. The restrictor receives the first mobile phase stream from the splitter and has a temperature element in thermal communication with the first mobile phase stream to exchange heat therewith. A controller, in communication with the restrictor, dynamically adjusts a temperature setting of the temperature element of the restrictor to adjust the heat exchange between the thermally modulated variable restrictor and the first mobile phase stream in order to keep the split ratio constant throughout a chromatographic run.

公开(公告)号：EP2809414A4

公开(公告)日：2015-11-25

申请号：EP13743375

申请日：2013-01-30

申请人： WATERS TECHNOLOGIES CORP

发明人： GERHARDT GEOFF C ,  FADGEN KEITH EDWARD ,  MICHIENZI JOSEPH D ,  BUNNER BERNARD

IPC分类号： B01D15/08 ,  B62D5/083 ,  G01N30/20

CPC分类号： G01N30/38 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/567 ,  B01L2200/0689 ,  B01L2400/0622 ,  B01L2400/0644 ,  F04D15/00 ,  F04D29/086 ,  F16K99/0013 ,  G01N30/20 ,  G01N2030/202

公开(公告)号：EP2403621A4

公开(公告)日：2013-12-18

申请号：EP10749381

申请日：2010-03-05

申请人： WATERS TECHNOLOGIES CORP

发明人： PRENTICE DAVID P ,  KEENE RUSSELL L ,  KOZIOL STANISLAW ,  MICHIENZI JOSEPH D ,  LINDERSON PAUL E

IPC分类号： G01N30/72 ,  B01L3/02 ,  G01N27/447 ,  G01N30/60 ,  H01J49/04 ,  H01J49/16

CPC分类号： B01D15/10 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L3/563 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0883 ,  B05B1/00 ,  B05B1/02 ,  G01N27/44791 ,  G01N30/6095 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/724 ,  G01N30/7266 ,  H01J49/167 ,  Y10T137/598 ,  Y10T436/24

摘要： An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.

公开(公告)号：EP2972291A4

公开(公告)日：2016-10-26

申请号：EP14764098

申请日：2014-01-27

申请人： WATERS TECHNOLOGIES CORP

发明人： FOGWILL MICHAEL O ,  MICHIENZI JOSEPH D ,  MURPHY JAMES P

IPC分类号： G01N30/32 ,  B01D15/16 ,  B01D15/40 ,  G01N30/30 ,  G01N30/60

CPC分类号： G01N30/30 ,  B01D15/163 ,  B01D15/40 ,  G01N30/32 ,  G01N30/6004 ,  G01N2030/3038 ,  G01N2030/324 ,  G01N2030/6008

公开(公告)号：EP2748599A4

公开(公告)日：2015-07-01

申请号：EP12826759

申请日：2012-08-23

申请人： WATERS TECHNOLOGIES CORP

发明人： MICHIENZI JOSEPH D

IPC分类号： B01D15/08 ,  B01L3/00

CPC分类号： B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

摘要： An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.

公开(公告)号：EP2435154A4

公开(公告)日：2013-11-06

申请号：EP10781181

申请日：2010-05-27

申请人： WATERS TECHNOLOGIES CORP

发明人： MICHIENZI JOSEPH D ,  MURPHY JAMES P ,  DELLAROVERE DENNIS

IPC分类号： B01D15/08 ,  B01L3/00 ,  G01N30/08 ,  G01N30/46 ,  G01N30/60 ,  G01N30/72

CPC分类号： G01N30/6095 ,  B01D15/22 ,  B01D15/424 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2400/0487 ,  G01N30/461 ,  G01N30/606 ,  G01N30/6091 ,  G01N30/7233 ,  G01N30/7266 ,  G01N2030/027 ,  G01N2030/085 ,  G01N2030/8881 ,  Y10T29/49826

摘要： A method of analyzing samples includes loading a sufficient quantity of the sample onto a trap column to overload the trap column; heating an analytical column and the trap column to a greater temperature than the analytical column; and pumping a solvent, to the trap column, having a solvent composition profile that, in cooperation with a temperature differential, causes at least some of the components to elute sequentially from the trap column to the analytical column and focus on the analytical column prior to eluting from the analytical column; or optionally: loading a small-molecule sample onto a cooled portion of an analytical column; heating the analytical column; and pumping a solvent, to the heated analytical column, to elute the components from the analytical column. Chromatographic separation includes: a trap column; a separation column; a trap-column heater; a separation-column heater; a solvent pump unit; and a control unit can be used.

公开(公告)号：EP2344857A4

公开(公告)日：2016-02-24

申请号：EP09824085

申请日：2009-10-28

申请人： WATERS TECHNOLOGIES CORP

发明人： LUONGO JOSEPH A ,  BUDNICK MICHAEL ,  MOELLER MARK W ,  GERHARDT GEOFF C ,  MURPHY JAMES P ,  FADGEN KEITH ,  MICHIENZI JOSEPH D

IPC分类号： G01N1/10

CPC分类号： F16K11/074 ,  F16K25/005 ,  G01N2030/202

公开(公告)号：EP2748600A4

公开(公告)日：2015-06-10

申请号：EP12826104

申请日：2012-08-22

申请人： WATERS TECHNOLOGIES CORP

发明人： MURPHY JAMES P ,  TOMANY MICHAEL J ,  MICHIENZI JOSEPH D ,  RAINVILLE PAUL ,  PLUMB ROBERT S ,  GERHARDT GEOFF C ,  JUNG MOON CHUL

IPC分类号： G01N30/06 ,  B01L3/00 ,  G01N1/38 ,  G01N30/16 ,  G01N30/46 ,  G01N30/60 ,  G01N30/88 ,  G01N33/96

CPC分类号： G01N30/06 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1827 ,  G01N30/16 ,  G01N30/6095 ,  G01N30/88 ,  G01N33/49 ,  G01N2001/383 ,  G01N2030/009 ,  G01N2030/062

公开(公告)号：EP2748504A4

公开(公告)日：2015-04-29

申请号：EP12828696

申请日：2012-08-23

申请人： WATERS TECHNOLOGIES CORP

发明人： MICHIENZI JOSEPH D

IPC分类号： G01N30/60 ,  F16L19/02

CPC分类号： B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

摘要： An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.