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公开(公告)号：EP4242238A2
公开(公告)日：2023-09-13
申请号：EP23171719.0
申请日：2019-05-14
发明人： WINSTON, William , HICKLIN, Daniel , BHASKAR, Vinay , EVNIN, Luke , BAEUERLE, Patrick , SALMERON GARCIA, Jose Andres , BRODKIN, Heather , LIN, Shuoyen Jack , WESCHE, Holger , SEIDEL-DUGAN, Cynthia
IPC分类号： C07K19/00
摘要： The disclosure features fusion proteins that are conditionally active variants of IL-2. In one aspect, the full-length polypeptides of the invention have reduced or minimal cytokine-receptor activating activity even though they contain a functional cytokine polypeptide. Upon activation, e.g., by cleavage of a linker that joins a blocking moiety, e.g. a steric blocking polypeptide, in sequence to the active cytokine, the cytokine can bind its receptor and effect signaling.
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公开(公告)号：EP3794022A1
公开(公告)日：2021-03-24
申请号：EP19728803.8
申请日：2019-05-14
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公开(公告)号：EP3794024A1
公开(公告)日：2021-03-24
申请号：EP19729416.8
申请日：2019-05-14
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公开(公告)号：EP4242238A3
公开(公告)日：2023-12-06
申请号：EP23171719.0
申请日：2019-05-14
发明人： WINSTON, William , HICKLIN, Daniel , BHASKAR, Vinay , EVNIN, Luke , BAEUERLE, Patrick , SALMERON GARCIA, Jose Andres , BRODKIN, Heather , LIN, Shuoyen Jack , WESCHE, Holger , SEIDEL-DUGAN, Cynthia
摘要： The disclosure features fusion proteins that are conditionally active variants of IL-2. In one aspect, the full-length polypeptides of the invention have reduced or minimal cytokine-receptor activating activity even though they contain a functional cytokine polypeptide. Upon activation, e.g., by cleavage of a linker that joins a blocking moiety, e.g. a steric blocking polypeptide, in sequence to the active cytokine, the cytokine can bind its receptor and effect signaling.
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公开(公告)号：EP3794023A1
公开(公告)日：2021-03-24
申请号：EP19728804.6
申请日：2019-05-14
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