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公开(公告)号：EP4387650A2
公开(公告)日：2024-06-26
申请号：EP22859050.1
申请日：2022-08-16
发明人： WINSTON, William , HICKLIN, Daniel , SALMERON-GARCIA, Jose Andres , SEIDEL-DUGAN, Cynthia , BRODKIN, Heather , ISAACS, Randi
IPC分类号： A61K38/20 , C07K14/55 , C07K14/715 , C07K16/28 , A61P35/00
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公开(公告)号：EP4242238A2
公开(公告)日：2023-09-13
申请号：EP23171719.0
申请日：2019-05-14
发明人： WINSTON, William , HICKLIN, Daniel , BHASKAR, Vinay , EVNIN, Luke , BAEUERLE, Patrick , SALMERON GARCIA, Jose Andres , BRODKIN, Heather , LIN, Shuoyen Jack , WESCHE, Holger , SEIDEL-DUGAN, Cynthia
IPC分类号： C07K19/00
摘要： The disclosure features fusion proteins that are conditionally active variants of IL-2. In one aspect, the full-length polypeptides of the invention have reduced or minimal cytokine-receptor activating activity even though they contain a functional cytokine polypeptide. Upon activation, e.g., by cleavage of a linker that joins a blocking moiety, e.g. a steric blocking polypeptide, in sequence to the active cytokine, the cytokine can bind its receptor and effect signaling.
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公开(公告)号：EP4387649A1
公开(公告)日：2024-06-26
申请号：EP22859046.9
申请日：2022-08-16
发明人： WINSTON, William , HICKLIN, Daniel , SALMERON-GARCIA, Jose Andres , SEIDEL-DUGAN, Cynthia , BRODKIN, Heather , STEINER, Philipp
IPC分类号： A61K38/20 , A61K38/21 , A61K39/395 , A61P35/00 , C07K14/54 , C07K14/555
CPC分类号： A61K38/21 , A61P35/00 , C07K14/555 , A61K2039/50520130101 , C07K16/2818 , A61K39/3955 , C07K14/55 , C07K14/5434 , C07K2319/3120130101 , C07K2319/3020130101 , C07K2319/5020130101 , A61K38/2013 , A61K38/208 , A61K9/0019
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公开(公告)号：EP3794022A1
公开(公告)日：2021-03-24
申请号：EP19728803.8
申请日：2019-05-14
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公开(公告)号：EP4387987A2
公开(公告)日：2024-06-26
申请号：EP22792938.7
申请日：2022-08-17
发明人： WINSTON, William , HICKLIN, Daniel , SALMERON-GARCIA, Jose, Andres , SEIDEL-DUGAN, Cynthia , BRODKIN, Heather , STEINER, Philipp
IPC分类号： C07K14/52 , A61K38/21 , A61K39/395 , C07K14/555 , C07K14/56
CPC分类号： C07K14/52 , C07K14/555 , C07K14/56 , C07K2319/5020130101 , C07K2319/3120130101 , A61K38/21 , A61P35/00 , A61P31/12
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公开(公告)号：EP4058471A1
公开(公告)日：2022-09-21
申请号：EP20821517.8
申请日：2020-11-14
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公开(公告)号：EP3969035A1
公开(公告)日：2022-03-23
申请号：EP20804817.3
申请日：2020-05-14
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公开(公告)号：EP3794024A1
公开(公告)日：2021-03-24
申请号：EP19729416.8
申请日：2019-05-14
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公开(公告)号：EP4412712A1
公开(公告)日：2024-08-14
申请号：EP22797609.9
申请日：2022-10-07
发明人： SALMERON-GARCIA, Jose Andres , WINSTON, William , HICKLIN, Daniel , SEIDEL-DUGAN, Cynthia , BRODKIN, Heather , NIRSCHL, Christopher , CAFARELLI, Tiziana
CPC分类号： A61K38/2013 , A61P35/00
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公开(公告)号：EP4242238A3
公开(公告)日：2023-12-06
申请号：EP23171719.0
申请日：2019-05-14
发明人： WINSTON, William , HICKLIN, Daniel , BHASKAR, Vinay , EVNIN, Luke , BAEUERLE, Patrick , SALMERON GARCIA, Jose Andres , BRODKIN, Heather , LIN, Shuoyen Jack , WESCHE, Holger , SEIDEL-DUGAN, Cynthia
摘要： The disclosure features fusion proteins that are conditionally active variants of IL-2. In one aspect, the full-length polypeptides of the invention have reduced or minimal cytokine-receptor activating activity even though they contain a functional cytokine polypeptide. Upon activation, e.g., by cleavage of a linker that joins a blocking moiety, e.g. a steric blocking polypeptide, in sequence to the active cytokine, the cytokine can bind its receptor and effect signaling.
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