公开(公告)号：EP3212196A4

公开(公告)日：2018-07-11

申请号：EP15854524

申请日：2015-10-29

申请人： WISCONSIN ALUMNI RES FOUND

发明人： RAINES RONALD T ,  WINDSOR IAN ,  PALTE MICHAEL ,  LUKESH JOHN

IPC分类号： A61K31/69 ,  A61K31/341 ,  A61K31/366 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4433 ,  A61K33/22 ,  A61P31/18 ,  C07C311/15 ,  C07F5/02

CPC分类号： C07F5/025 ,  A61K31/00 ,  A61K31/34 ,  A61K31/341 ,  A61K31/366 ,  A61K31/427 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/69 ,  A61K33/22 ,  A61K2300/00

摘要： Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly HIV protease inhibitors which are boronated to enhance activity or to enhance entry into cells. Compounds, prodrugs and salts thereof of this invention contain phenylboronate groups, in particular p -B(OH)2-phenyl groups, benzoxaborole groups or borono-pyridyl groups or analogous groups in which the boronate group is protected. Methods for treating AIDS and ARC as well as providing a method for treating or preventing HIV infection.