-
1.发明公开2-METHYLENE-19-NOR-(20S)-1ALPHA-HYDROXY-TRISHOMOPREGNACALCIFEROL 审中-公开2-亚甲基-19-去甲（20S）-1ALPHA羟基TRISHOMOPREGNACALCIFEROL
公开(公告)号：EP1828115A2
公开(公告)日：2007-09-05
申请号：EP05851832.5
申请日：2005-11-18
IPC分类号： C07C401/00
CPC分类号： C07C401/00 , Y02P20/55
摘要： Compounds of formula (I) are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
摘要翻译： 提供式（I）化合物，其中X 1和X 2独立地选自H或羟基保护基。 此类化合物可用于制备药物组合物并可用于治疗各种生物学病症。
-
公开(公告)号：EP1981843A2
公开(公告)日：2008-10-22
申请号：EP07763317.0
申请日：2007-01-31
发明人： DELUCA, Hector F. , CHIELLINI, Grazia , GRZYWACZ, Pawel , PLUM, Lori A. , CLAGETT-DAME, Margaret
CPC分类号： C07C401/00 , C07F7/1856 , Y02P20/55
摘要： Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms; straight or branched chain alkenyl groups having from 2 to 8 carbon atoms; straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms; straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
-
3.发明公开2-METHYLENE-19-NOR-(20S-24EPI)-1ALPHA,25-DIHYDROXYVITAMINE-D2 有权2-亚甲基 - -19-去甲（20S-24EPI）-1ALPHA，25-DIHYDROVITAMIN-D2
公开(公告)号：EP1848442A1
公开(公告)日：2007-10-31
申请号：EP06734708.8
申请日：2006-02-10
IPC分类号： A61K31/569 , C07C401/00
CPC分类号： C07C401/00 , Y02P20/55
摘要： Compounds of formula I are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
-
4.发明公开
公开(公告)号：EP3331533A1
公开(公告)日：2018-06-13
申请号：EP16747962.5
申请日：2016-07-26
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： C07C35/21 , A61K31/59 , A61K31/593 , C07C401/00 , C07C2601/14 , C07C2602/24 , C07F7/1804
摘要： Disclosed are 2-methylene analogs of vitamin D3 and related compounds, their biological activities, and various pharmaceutical uses for these analogs. Particularly disclosed are 1α-hydroxy-2-methylene-vitamin D3, (20S)-1α-hydroxy-2-methylene-vitamin D3, and (5E)-1α,25-dihydroxy-2-methylene-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds including methods of treating and/or preventing bone diseases and disorders.
-
5.发明公开(20S)-2-METHYLENE-19-NOR-22-DIMETHYL-1ALPHA,25- DIHYDROXYVITAMIN D3 AND (20R)-2-METHYLENE-19-NOR-22-DIMETHYL-1ALPHA,25-HYDROXYVITAMIN D3 有权（20S）-2-甲基-19-异-D-二甲基-1ALPHA，25-二羟基维生素D3（20R）-2-甲基-19-异-D-二甲基-1ALPHA，25-羟基维生素D3
公开(公告)号：EP2556053A2
公开(公告)日：2013-02-13
申请号：EP11711237.5
申请日：2011-03-22
发明人： DELUCA, Hector F. , FLORES, Agnieszka , GRZYWACZ, Pawel , PLUM, Lori A. , CLAGETT-DAME, Margaret
CPC分类号： C07F7/1856 , C07C401/00 , C07C2601/14 , C07C2602/24 , Y02P20/55
摘要： Compounds of formula I are provided where X
1 , X
2 and X
3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.摘要翻译： 提供式I化合物，其中X 1，X 2和X 3独立地选自H或羟基保护基。 这些化合物可用于制备药物组合物，并且可用于治疗各种生物学条件。
-
6.发明公开2-METHYLENE-(20S,25S)-19,27-DINOR-(22E)-VITAMIN D ANALOGS 有权2-亚甲基 - （20S，25S）-19.27-DINOR（22E） - 维生素D类似物
公开(公告)号：EP2069296A2
公开(公告)日：2009-06-17
申请号：EP07843117.8
申请日：2007-09-25
发明人： DELUCA, Hector F. , CLAGETT-DAME, Margaret , PLUM, Lori A. , CHIELLINI, Grazia , GRZYWACZ, Pawel
IPC分类号： C07C401/00 , A61K31/59 , A61P35/00 , A61P35/02 , A61P17/06 , A61P37/06 , A61P29/00 , A61P17/00 , A61P3/04
CPC分类号： C07C401/00
摘要： This invention discloses 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,27-dinor-(22E)-1α,25- dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
-
公开(公告)号：EP2509943A1
公开(公告)日：2012-10-17
申请号：EP10834012.6
申请日：2010-11-29
IPC分类号： C07C401/00 , A61K31/59 , A61K31/593 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07C401/00 , A61K31/593 , C07C2601/14 , C07C2602/24 , Y02P20/55
摘要： Compounds of formula I are provided where X
1 and X
2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.摘要翻译： 提供式I化合物，其中X 1和X 2独立地选自H或羟基保护基。 这些化合物可用于制备药物组合物，并且可用于治疗各种生物学条件。
-
8.发明授权2-METHYLENE-19-NOR-(20S-24EPI)-1ALPHA,25-DIHYDROXYVITAMINE-D2 有权2-亚甲基-19-去（20S 24EPI）-1ALPHA，25-二氢维生素D2
公开(公告)号：EP1848442B1
公开(公告)日：2012-04-25
申请号：EP06734708.8
申请日：2006-02-10
IPC分类号： A61K31/569 , C07C401/00 , A61P19/10 , A61P35/00
CPC分类号： C07C401/00 , Y02P20/55
摘要： Compounds of formula I are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
-
9.发明授权2-METHYLENE-19,21-DINOR-1ALPHA-HYDROXY-BISHOMOPREGNACALCIFEROL 有权2-亚甲基-19,21- DINOR-1α羟基BISHOMOPREGNACALCIFEROL
公开(公告)号：EP1827452B1
公开(公告)日：2011-03-02
申请号：EP05849207.5
申请日：2005-11-18
IPC分类号： A61K31/59 , C07C401/00
CPC分类号： C07C401/00 , Y02P20/55
摘要： Compounds of formula (I) are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
摘要翻译： 提供式（I）化合物，其中X 1和X 2独立地选自H或羟基保护基。 此类化合物可用于制备药物组合物并可用于治疗各种生物学病症。
-
公开(公告)号：EP1981843B1
公开(公告)日：2009-12-09
申请号：EP07763317.0
申请日：2007-01-31
发明人： DELUCA, Hector F. , CHIELLINI, Grazia , GRZYWACZ, Pawel , PLUM, Lori A. , CLAGETT-DAME, Margaret
CPC分类号： C07C401/00 , C07F7/1856 , Y02P20/55
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.016 秒)
