专利检索 ap:("WOCKHARDT LTD" OR "JAWEED MUKARRAM SIDDIQUI MOHAM" OR "BHARGAV KRISHNAJI UPADHYE" OR "MISHRA KRISHNA GOPALJI" OR "FAROOQUI MOHAMMED ISMAIL") AND inv:"BHARGAV KRISHNAJI UPADHYE" 第 1 页

1.

发明公开
IMPROVED PROCESS FOR THE MANUFACTURE OF CITALOPRAM HYDROBROMIDE 审中-公开
标题翻译：改进的方法PRODUCING氢溴酸西酞普兰

公开(公告)号：EP1678122A4

公开(公告)日：2007-05-23

申请号：EP03769715

申请日：2003-10-28

申请人： WOCKHARDT LTD , JAWEED MUKARRAM SIDDIQUI MOHAM , BHARGAV KRISHNAJI UPADHYE , MISHRA KRISHNA GOPALJI , FAROOQUI MOHAMMED ISMAIL

发明人： JAWEED MUKARRAM SIDDIQUI MOHAM , BHARGAV KRISHNAJI UPADHYE , MISHRA KRISHNA GOPALJI , FAROOQUI MOHAMMED ISMAIL

IPC分类号： C07C255/00 , C07C215/34 , C07D307/78 , C07D307/87

CPC分类号： C07D307/87 , C07C215/34

摘要： The present invention describes an improved process for the preparation of extremely pure 1-(4'-Fluorophenyl)-1-(3-dimethylaminopropyl)-5-phthalanecarbonitrile and its bromide salt (citalopram hydrobromide), which is a well known antidepressant. Other aspect of the invention are isolation of crystalline (4-Bromo-2-hydroxymethyl)phenyl-(4-fluorophenyl)-3-(dimethylaminopropyl)methanol (Bromodiol) and conversion of desmethylcitalopram which is formed during the cyanide exchange reaction, to Citalopram by heating with a mixture of formaldhyde and formic acid in chloroform. The resulting citalopram is conventionally purified using extraction methodology.

2.

发明公开
METHOD FOR THE MANUFACTURE OF L-THREONINE-O-(1,1-DIMETHYLETHYL)-1,1-DIMETHYLETHYL ESTER 审中-公开
标题翻译：用于生产L-苏氨酸的O-（1,1-二甲基乙基）-1,1-二甲基乙基

公开(公告)号：EP1663949A4

公开(公告)日：2006-12-13

申请号：EP03818508

申请日：2003-09-08

申请人： WOCKHARDT LTD , JAWEED MUKARRAM SIDDIQUI MOHAM , BHARGAV KRISHNAJI UPADHYE , HEGDE DEEP VIRUPAKSHA

发明人： JAWEED MUKARRAM SIDDIQUI MOHAM , BHARGAV KRISHNAJI UPADHYE , HEGDE DEEP VIRUPAKSHA

IPC分类号： C07C227/18 , C07C229/22

CPC分类号： C07C227/18 , C07C229/22

摘要： The present invention relates to a new and efficient process for the manufacture of L-Threonine-O-(1,1-dimethylethyl) ester; [H-Thr-(tBu)-O-tBu] of Formula (I). The compound of Formula (I) is a key product for the manufacture of human insulin from porcine or bovine insulin.