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1.发明公开METHOD FOR THE MANUFACTURE OF L-THREONINE-O-(1,1-DIMETHYLETHYL)-1,1-DIMETHYLETHYL ESTER 审中-公开用于生产L-苏氨酸的O-（1,1-二甲基乙基）-1,1-二甲基乙基
公开(公告)号：EP1663949A4
公开(公告)日：2006-12-13
申请号：EP03818508
申请日：2003-09-08
申请人： WOCKHARDT LTD , JAWEED MUKARRAM SIDDIQUI MOHAM , BHARGAV KRISHNAJI UPADHYE , HEGDE DEEP VIRUPAKSHA
IPC分类号： C07C227/18 , C07C229/22
CPC分类号： C07C227/18 , C07C229/22
摘要： The present invention relates to a new and efficient process for the manufacture of L-Threonine-O-(1,1-dimethylethyl) ester; [H-Thr-(tBu)-O-tBu] of Formula (I). The compound of Formula (I) is a key product for the manufacture of human insulin from porcine or bovine insulin.
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公开(公告)号：EP1678122A4
公开(公告)日：2007-05-23
申请号：EP03769715
申请日：2003-10-28
申请人： WOCKHARDT LTD , JAWEED MUKARRAM SIDDIQUI MOHAM , BHARGAV KRISHNAJI UPADHYE , MISHRA KRISHNA GOPALJI , FAROOQUI MOHAMMED ISMAIL
发明人： JAWEED MUKARRAM SIDDIQUI MOHAM , BHARGAV KRISHNAJI UPADHYE , MISHRA KRISHNA GOPALJI , FAROOQUI MOHAMMED ISMAIL
IPC分类号： C07C255/00 , C07C215/34 , C07D307/78 , C07D307/87
CPC分类号： C07D307/87 , C07C215/34
摘要： The present invention describes an improved process for the preparation of extremely pure 1-(4'-Fluorophenyl)-1-(3-dimethylaminopropyl)-5-phthalanecarbonitrile and its bromide salt (citalopram hydrobromide), which is a well known antidepressant. Other aspect of the invention are isolation of crystalline (4-Bromo-2-hydroxymethyl)phenyl-(4-fluorophenyl)-3-(dimethylaminopropyl)methanol (Bromodiol) and conversion of desmethylcitalopram which is formed during the cyanide exchange reaction, to Citalopram by heating with a mixture of formaldhyde and formic acid in chloroform. The resulting citalopram is conventionally purified using extraction methodology.
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3.发明公开AN EFFICIENT PROCESS FOR THE MANUFACTURE OF (E)-ENTACAPONE POLYMORPHIC FORM A 审中-公开高效方法（E）的-ENTACAPON多晶型物的制造
公开(公告)号：EP1701936A4
公开(公告)日：2007-01-24
申请号：EP03819304
申请日：2003-12-24
IPC分类号： C07C255/03 , C07C255/41
CPC分类号： C07C255/41 , C07B2200/13
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4.发明公开PROCESS FOR THE PREPARING ZIPRASIDONE MONOHYDROCHLORIDE HYDRATE 审中-公开用于生产ZIPRASIDONMONOHYDROCHLORID水合物
公开(公告)号：EP1687300A4
公开(公告)日：2007-08-01
申请号：EP03778599
申请日：2003-11-28
申请人： WOCKHARDT LTD , JAWEED MUKARRAM SIDDIQUI MOHAM , MERWADE ARAVIND YEKANATHSA , SINGH KUMAR KAMLESH LAXMI , SOLANKI PAWAN VRAJLAL
发明人： JAWEED MUKARRAM SIDDIQUI MOHAM , MERWADE ARAVIND YEKANATHSA , SINGH KUMAR KAMLESH LAXMI , SOLANKI PAWAN VRAJLAL
IPC分类号： C07D417/04 , C07D417/12
CPC分类号： C07D417/12
摘要： The present invention describes a process for preparing 5-(2-(4-1,2-benzisothiazol-3-yl)piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one (Ziprasidone) monohydrochloride hydrate or a pharmaceutically acceptable acid addition salt thereof, which is well known agent for treating various disorders including schizophrenia, migraine pain and anxiety. The manufacturing process of Ziprasidone comprises the reaction of hydrochloride salt of 1,2-benzisothiazole-3-piprazinyl with 2-Chloroethyl-6-chlorooxindole in aqueous sodium carbonate solution. Its hydrochloride salt is prepared in aqueous methanol using hydrogen chloride.
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5.发明公开STABLE POLYMORPHS OF (E)-N,N-DIETHYL-2-CYANO-3-(3,4-DIHYDROXY-5-NITROPHENYL)ACRYLAMIDE 审中-公开（E）-N，N-二乙基-2-氰基-3-（3,4-二羟基-5-硝基苯基）丙烯酰胺
公开(公告)号：EP1701937A4
公开(公告)日：2007-05-02
申请号：EP03768046
申请日：2003-12-29
申请人： WOCKHARDT LTD , JAWEED MUKARRAM SIDDIQUI MOHAM , KHAN RASHID ABDUL REHMAN , YAVAD RAM PRASAD , SHAIKH ZAKIR GAFOOR
发明人： JAWEED MUKARRAM SIDDIQUI MOHAM , KHAN RASHID ABDUL REHMAN , YADAV RAM PRASAD , SHAIKH ZAKIR GAFOOR
IPC分类号： C07C255/07 , C07C255/41
CPC分类号： C07C255/41 , C07B2200/13
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6.发明公开A NOVEL PROCESS FOR THE MANUFACTURE OF (+)-(S)-CLOPIDOGREL BISULFATE FORM-I 有权NEUES VERFAHREN ZUR HERSTELLUNG VON（+） - （S）-CLOPIDOGRELBISULFAT FORM-I
公开(公告)号：EP1651646A4
公开(公告)日：2007-03-21
申请号：EP03817742
申请日：2003-08-04
IPC分类号： C07D495/04 , A61K31/4738 , A61P9/00
CPC分类号： C07D495/04
摘要： The present invention relates to a novel process for the manufacture of blood-platelet aggregation inhibiting agent. In particular, the present invention is directed to a process for the manufacture of Methyl-(+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-S-(4H)acetate bisulfate Form-I.
摘要翻译： 本发明涉及一种制备血小板聚集抑制剂的新方法。 具体地说，本发明涉及制备（+） - （S）-α-（2-氯苯基）-6,7-二氢噻吩并[3,2-c]吡啶-5-（ 4H）乙酸盐硫酸氢盐形式-I。
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公开(公告)号：EP1313749A4
公开(公告)日：2004-01-21
申请号：EP01958277
申请日：2001-08-23
申请人： WOCKHARDT LTD , KHAN ANJUM REYAZ , SINGH SHIVA PRASAD , JAWEED MUKARRAM SIDDIQUI MOHAM , PUROHIT MANISH
IPC分类号： C07H17/00 , A61K31/7052 , A61P31/04 , C07D407/14 , C07H17/08 , A61K31/7048
CPC分类号： C07D407/14
摘要： The present invention provides a stable form of azithromycin derivatives that act as antibiotics. These compounds are in anhydrous form and have increased stability over the hydrated forms.
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