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    METHOD FOR DETERMINING RISK OF PRE-ECLAMPSIA
    1.
    发明公开
    METHOD FOR DETERMINING RISK OF PRE-ECLAMPSIA 审中-公开
    确定前 - 肺结核风险的方法

    公开(公告)号：EP3189336A1

    公开(公告)日：2017-07-12

    申请号：EP15770959.3

    申请日：2015-09-01

    申请人： Wallac OY

    发明人： AHOLA, Tarja ,  KOURU, Heikki ,  SAIRANEN, Mikko

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N33/74 ,  G01N2333/70564 ,  G01N2800/368

    摘要： The present description relates to a method for determining the risk of a pregnant woman with chronic hypertension developing early or late onset pre-eclampsia. The present description provides methods useful for determining risk that a pregnant individual with chronic hypertension will develop an early pre-eclampsia or late pre-eclampsia. Useful combination of biochemical markers including PlGF and sP-Selectin and related clinical population studies are described herein.

    摘要翻译： 本发明涉及一种确定患有慢性高血压的孕妇早发或晚发先兆子痫的风险的方法。 本说明书提供了用于确定具有慢性高血压的怀孕个体发展早期先兆子痫或晚期先兆子痫的风险的方法。 本文描述了包括PlGF和sP-选择素在内的生物化学标志物的有用组合和相关临床群体研究。

    SYSTEM AND METHOD FOR DETERMINING RISK OF PRE-ECLAMPSIA BASED ON BIOCHEMICAL MARKER ANALYSIS
    3.
    发明公开
    SYSTEM AND METHOD FOR DETERMINING RISK OF PRE-ECLAMPSIA BASED ON BIOCHEMICAL MARKER ANALYSIS 审中-公开
    系统VERFAHREN ZUR BESTIMMUNG EINESFRÜHGEBURTSRISIKOSAUF基础分析生物化学品商标

    公开(公告)号：EP2972383A1

    公开(公告)日：2016-01-20

    申请号：EP14713260.9

    申请日：2014-02-26

    申请人： WALLAC OY

    发明人： HURSKAINEN, Pertti ,  KORPIMÄKI, Teemu ,  KOURU, Heikki ,  SAIRANEN, Mikko

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N2333/47 ,  G01N2333/475 ,  G01N2333/515 ,  G01N2800/368 ,  G01N2800/50 ,  G16B40/00

    摘要： A method for predicting risk of pre-eclampsia in a pregnant individual includes measuring one or more biochemical markers including an RBP4 biochemical marker in a blood sample obtained from the pregnant individual to determine one or more biomarker levels including an RBP4 biomarker level, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing pre-eclampsia.

    摘要翻译： 用于预测怀孕个体中先兆子痫风险的方法包括在从怀孕个体获得的血液样品中测量一种或多种生物化学标志物，包括RBP4生物化学标志物，以确定包括RBP4生物标志物水平的一种或多种生物标志物水平，鉴定 所述一个或多个测量的生物化学标记中的每一个，所测量的生物标志物水平与相应的预定对照水平之间的差异，并且响应于所述鉴定，确定对应于具有或发展先兆子痫的孕妇的相对风险的预测。

    SYSTEM AND METHOD FOR DETERMINING RISK OF DIABETES BASED ON BIOCHEMICAL MARKER ANALYSIS
    5.
    发明公开
    SYSTEM AND METHOD FOR DETERMINING RISK OF DIABETES BASED ON BIOCHEMICAL MARKER ANALYSIS 有权
    系统在VERFAHREN ZUR BESTIMMUNG DES DIABETESRISIKOS AUF基础DER分析生物化学品商标

    公开(公告)号：EP2972385A2

    公开(公告)日：2016-01-20

    申请号：EP14715412.4

    申请日：2014-02-26

    申请人： WALLAC OY

    发明人： HURSKAINEN, Pertti ,  KORPIMÄKI, Teemu ,  KOURU, Heikki ,  SAIRANEN, Mikko

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N2333/8132 ,  G01N2800/042 ,  G01N2800/368 ,  G01N2800/54

    摘要： A method for predicting risk of gestational diabetes mellitus (GDM) in a pregnant individual includes measuring one or more biochemical markers in a blood sample obtained from the pregnant individual to determine one or more biomarker levels, where the one or more measured biochemical markers includes at least one of PAI-2 and sTNFR1, identifying, for each of the one or more measured biochemical markers, a difference between the measured biomarker level and a corresponding predetermined control level, and, responsive to the identifying, determining a prediction corresponding to a relative risk of the pregnant individual having or developing GDM.

    摘要翻译： 用于预测怀孕个体的妊娠糖尿病（GDM）的风险的方法包括测量从怀孕个体获得的血液样品中的一种或多种生物化学标记物，以确定一种或多种生物标志物水平，其中所述一种或多种测量的生物化学标记物包括在 PAI-2和sTNFR1中的至少一个，针对所述一个或多个测量的生物化学标记中的每一个标识所测量的生物标志物水平与相应的预定控制水平之间的差异，并且响应于所述鉴定，确定对应于相对 怀孕个体患有或发展GDM的风险。

    METHOD FOR DETERMINING THE RISK OF PRETERM BIRTH
    8.
    发明公开
    METHOD FOR DETERMINING THE RISK OF PRETERM BIRTH 审中-公开
    确定预产生风险的方法

    公开(公告)号：EP3194979A1

    公开(公告)日：2017-07-26

    申请号：EP15774940.9

    申请日：2015-09-11

    申请人： Wallac OY

    发明人： HURSKAINEN, Pertti ,  KOURU, Heikki ,  SAIRANEN, Mikko ,  AHOLA, Tarja ,  KORPIMÄKI, Teemu

    IPC分类号： G01N33/68

    CPC分类号： G01N33/689 ,  G01N2800/368

    摘要： The present invention relates to a method for determining risk of preterm birth (PTB) in a pregnant individual. The method comprises measuring in a biological sample obtained from the pregnant individual, levels of biomarkers AFP and free hCG-beta, and at least one biomarker selected from FSTL3, sTNR1, P1GF2, Activin A, Ue3 and sP-selectin and optionally cervical length; or levels of biomarkers AFP and free hCGbeta and cervical length, and determining a relative risk of the pregnant individual developing PTB. The invention relates also to a kit, apparatus and system for predicting risk of PTB.

    摘要翻译： 本发明涉及用于确定怀孕个体中早产风险（PTB）的方法。 该方法包括测量从怀孕个体获得的生物样品中生物标志物AFP和游离hCGβ的水平以及选自FSTL3，sTNR1，PlGF2，激活素A，Ue3和sP-选择素和任选的宫颈长度的至少一种生物标志物; 或生物标志物AFP和游离hCGβ和宫颈长度的水平，并确定怀孕个体发展PTB的相对风险。 本发明还涉及预测PTB风险的试剂盒，装置和系统。